Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino, Eleonora; Gasparri, F; Munaron, Luca

doi:10.3390/ijms21020523

Cited by 33 publications

(21 citation statements)

References 115 publications

(145 reference statements)

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“…All in all, while known compounds such as quercitrin and closely related O-glycosylated flavonols present in C. inophyllum were negatively correlated to cell proliferation (some significantly), C-glycosylated flavonols present in F. berteroana and C. inophyllum showed positive correlation patterns, although non-significant. These findings are supported by literature as flavonoids and flavonoid glycosides have been reported to have an inducing effect on hair growth and thus hair length, as well as hair width including a protective effect [45,46]. .…”

Section: Bioactivity-based Molecular Networking On Hair-related Targe...supporting

confidence: 82%

Feature-Based Molecular Networks Identification of Bioactive Metabolites from Three Plants of the Polynesian Cosmetopoeia Targeting the Dermal Papilla Cells of the Hair Cycle

Hughes

Greff

et al. 2021

Molecules

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The term cosmetopoeia refers to the use of plants in folks’ cosmetics. The aerial parts of Bidens pilosa L., the leaves of Calophyllum inophyllum L. and the fruits of Fagraea berteroana A.Gray ex Benth are traditionally used in French Polynesia for hair and skin care. During the hair cycle, dermal papilla cells and their interaction with epithelial cells are essential to promote hair follicle elongation. The aim of our investigations was the identification of metabolites from these three plants and chemical families responsible for their hair growth activity. A bioactivity-based molecular network was produced by mapping the correlation between features obtained from LC-MS/MS data and dermal papilla cell proliferation, using the Pearson correlation coefficient. The analyses pointed out glycosylated flavonols and phenolic acids from B. pilosa and C. inophyllum, along with C-flavonoids, iridoids and secoiridoids from F. berteroana, as potential bioactive molecules involved in the proliferation of hair follicle dermal papilla cells. Our results highlight the metabolites of the plant species potentially involved in the induction of hair follicle growth and support the traditional uses of these plants in hair care.

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Section: Bioactivity-based Molecular Networking On Hair-related Targe...supporting

confidence: 82%

Feature-Based Molecular Networks Identification of Bioactive Metabolites from Three Plants of the Polynesian Cosmetopoeia Targeting the Dermal Papilla Cells of the Hair Cycle

Hughes

Greff

et al. 2021

Molecules

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“…It reduces sugar metabolism in hair follicles and suppresses energy supply to shorten the hair follicle growth period. As a consequence, the duration of the resting phase of the hair increases, and the hair follicle gradually becomes thinner and shorter [ 117 , 118 ].…”

Section: Applications Of Mesenchymal Stem Cells In Skin Rejuvenatimentioning

confidence: 99%

Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

Brito

Kwak

et al. 2021

IJMS

123

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Mesenchymal stem cells (MSCs) are multipotent stem cells derived from adult stem cells. Primary MSCs can be obtained from diverse sources, including bone marrow, adipose tissue, and umbilical cord blood. Recently, MSCs have been recognized as therapeutic agents for skin regeneration and rejuvenation. The skin can be damaged by wounds, caused by cutting or breaking of the tissue, and burns. Moreover, skin aging is a process that occurs naturally but can be worsened by environmental pollution, exposure to ultraviolet radiation, alcohol consumption, tobacco use, and undernourishment. MSCs have healing capacities that can be applied in damaged and aged skin. In skin regeneration, MSCs increase cell proliferation and neovascularization, and decrease inflammation in skin injury lesions. In skin rejuvenation, MSCs lead to production of collagen and elastic fibers, inhibition of metalloproteinase activation, and promote protection from ultraviolet radiation-induced senescence. In this review, we focus on how MSCs and MSC-derived molecules improve diseased and aged skin. Additionally, we emphasize that induced pluripotent stem cell (iPSC)-derived MSCs are potentially advanced MSCs, which are suitable for cell therapy.

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“…High levels of NT5E (CD73) have also been found in hair follicle cells 42 . Dermal microcirculation is essential for supplying various growth factors and other bioactive molecules for hair maintenance 43 . Particularly, during the anagen phase, such a mechanism of dermal microcirculation is important for maintaining the high metabolic activity of hair follicle matrix cells.…”

Section: Discussionmentioning

confidence: 99%

A network pharmacology-based approach to explore mechanism of action of medicinal herbs for alopecia treatment

Leem

Jung

Park

et al. 2022

Sci Rep

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Hair loss is one of the most common skin problems experienced by more than half of the world's population. In East Asia, medicinal herbs have been used widely in clinical practice to treat hair loss. Recent studies, including systematic literature reviews, indicate that medicinal herbs may demonstrate potential effects for hair loss treatment. In a previous study, we identified medical herbs used frequently for alopecia treatment. Herein, we explored the potential novel therapeutic mechanisms of 20 vital medicinal herbs for alopecia treatment that could distinguish them from known mechanisms of conventional drugs using network pharmacology analysis methods. We determined the herb-ingredient–target protein networks and ingredient-associated protein (gene)-associated pathway networks and calculated the weighted degree centrality to define the strength of the connections. Data showed that 20 vital medicinal herbs could exert therapeutic effects on alopecia mainly mediated via regulation of various target genes and proteins, including acetylcholinesterase (AChE), phospholipase A2 (PLA2) subtypes, ecto-5-nucleotidase (NTE5), folate receptor (FR), nicotinamide N-methyltransferase (NNMT), and quinolinate phosphoribosyltransferase (QPRT). Findings regarding target genes/proteins and pathways of medicinal herbs associated with alopecia treatment offer insights for further research to better understand the pathogenesis and therapeutic mechanism of medicinal herbs for alopecia treatment with traditional herbal medicine.

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Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Cited by 33 publications

References 115 publications

Feature-Based Molecular Networks Identification of Bioactive Metabolites from Three Plants of the Polynesian Cosmetopoeia Targeting the Dermal Papilla Cells of the Hair Cycle

Feature-Based Molecular Networks Identification of Bioactive Metabolites from Three Plants of the Polynesian Cosmetopoeia Targeting the Dermal Papilla Cells of the Hair Cycle

Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

A network pharmacology-based approach to explore mechanism of action of medicinal herbs for alopecia treatment

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