<p>Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19</p>

Abstract

Background The rapid outbreak of coronavirus disease 2019 (COVID-19) is a major health concern, in response to which widespread risk factor research is being carried out. Objective To discover how physical activity and lifestyle affect the epidemic as well as the disease severity and prognosis of COVID-19 patients. Methods This multicenter, retrospective cohort study included 203 adults infected with COVID-19 and 228 uninfected adults in three Chinese provinces, with 164 (80.7%) of the infected participants and 188 (82.5%) of the uninfected participants answering a doctor-administered telephone questionnaire on lifestyle. The binary logistic regression model and the ordinal logit model were used to observe relevance. Results Comparing sick and non-sick patients, we found that irregular exercise ( P =0.004), sedentary lifestyle ( P =0.010), and overexertion ( P <0.001) may be associated with the susceptibility to COVID-19. In symptomatic patients, using the recommended status as a reference, risk of severe infection increased with decreased sleep status, being 6.729 (95% CI=2.138–21.181) times higher for potentially appropriate sleep ( P =0.001) and peaking at 8.612 (95% CI=1.913–38.760) times higher for lack of sleep ( P =0.005). Reduction in average daily sleep time significantly increased the likely severity ( P =0.002). Discussion Through further examination of damage of external lung organs, we found that lack of sleep affected not only disease severity but also prognosis. Based on these findings, the public should prioritize a healthy lifestyle and get adequate sleep in response to the outbreak. The study of life habits may bring new ideas for the prevention and treatment of COVID-19.

COVID-19 illness in relation to sleep and burnout

“…13 14 One prior study found that self-reported lack of sleep was associated with higher odds whereas 1-hour longer daily sleep time was associated with lower odds of ≥20 days of hospital stay due to COVID-19. 5 Our results on sleep hours at night are in agreement with this previous study, but we contribute to the literature by providing more comprehensive information on sleep habits. Several prior studies have already shown that short sleep duration prior to virus exposure is prospectively associated with a greater risk of acute infectious diseases, such as pneumonia and common cold.…”

“…4 Only one study examined the association between sleep duration and COVID-19 in 431 Chinese adults and found that lack of sleep was associated with greater severity of COVID-19 compared with the recommended sleep status. 5 However, this prior study did not have detailed questions on sleep habits, and no previous studies have examined whether other sleep habits and self-reported burnout are associated with COVID- 19 BMJ Nutrition, Prevention & Health these factors can help inform public health measures to support HCWs during the pandemic. Thus, we aimed to assess whether sleep habits and self-reported burnout may be risk factors for COVID-19 among at-risk HCWs.…”

Sleep disorders and COVID-19

“…At this time, there remains limited data regarding sleep dysfunction in patients who have been diagnosed with COVID-19, whether asymptomatic or symptomatic, whether requiring hospitalization or not, and among those hospitalized, whether requiring intensive care (ICU) admission due to respiratory failure or not. Huang et al [ 45 ] compared adults infected with COVID-19 to uninfected adults in three Chinese provinces and found that in symptomatic patients, risk of severe infection was six to eightfold higher in the presence of decreased sleep status and reduced sleep hours in the week prior to the diagnosis. In one study among 572 patients hospitalized for COVID-19 [ 46 ], the prevalence of insomnia was 11%; notably, these authors also found that the prevalence of OSA in this group was 19.8% and that of restless legs syndrome (RLS, recently renamed Willis-Ekbom disease) or periodic limb movements of sleep was 3.9%.…”

The Impact of Quarantine on Sleep Quality and Psychological Distress During the COVID-19 Pandemic

“…Based on the literature review, we included isolation status, age, gender, provinces of Saudi Arabia, social interaction, social media use, current covid-19 infection, symptomatic covid-19 infection, existing medical comorbidity, shiftwork, poor sleep, psychological distress and psychotropic or sleep medication use as independent variables in univariate analysis. [29][30][31][32][33][34] "Isolation" as well as variables with a P-value of less than 0.1 in the univariable analysis were included in the multivariable analysis. We reported the odds ratio and associated 95% Confidence Intervals (95% CI).…”