Sleep disorders and COVID-19

Bhat, Sushanth; Chokroverty, Sudhansu

doi:10.1016/j.sleep.2021.07.021

Cited by 104 publications

(90 citation statements)

References 107 publications

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“…Additional polysomnography studies should be performed to investigate possible differences in sleep dynamics between groups. In some recent studies sleep disturbances during infection were observed, even in mild COVID-19 patients 45 – 47 may have implications for the results of HRV analyses. Changes in sleep dynamics during infection could also affect the number of arousals during sleep, as well as the number of U-shaped patterns.…”

Section: Discussionmentioning

confidence: 97%

Heart rate variability comparison between young males after 4–6 weeks from the end of SARS-CoV-2 infection and controls

Soliński

Pawlak

Petelczyc

et al. 2022

Sci Rep

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Due to the prolonged inflammatory process induced by infection of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), indices of autonomic nervous system dysfunction may persist long after viral shedding. Previous studies showed significant changes in HRV parameters in severe (including fatal) infection of SARS-CoV-2. However, few studies have comprehensively examined HRV in individuals who previously presented as asymptomatic or mildly symptomatic cases of COVID-19. In this study, we examined HRV in asymptomatic or mildly symptomatic individuals 5–7 weeks following positive confirmation of SARS-CoV-2 infection. Sixty-five ECG Holter recordings from young (mean age 22.6 ± 3.4 years), physically fit male subjects 4–6 weeks after the second negative test (considered to be the start of recovery) and twenty-six control male subjects (mean age 23.2 ± 2.9 years) were considered in the study. Night-time RR time series were extracted from ECG signals. Selected linear as well as nonlinear HRV parameters were calculated. We found significant differences in Porta’s symbolic analysis parameters V0 and V2 (p < 0.001), α2 (p < 0.001), very low-frequency component (VLF; p = 0.022) and respiratory peak (from the PRSA method; p = 0.012). These differences may be caused by the changes of activity of the parasympathetic autonomic nervous system as well as by the coupling of respiratory rhythm with heart rate due to an increase in pulmonary arterial vascular resistance. The results suggest that the differences with the control group in the HRV parameters, that reflect the functional state of the autonomic nervous system, are measurable after a few weeks from the beginning of the recovery even in the post-COVID group—a young and physically active population. We indicate HRV sensitive markers which may be used in long-term monitoring of patients after recovery.

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Section: Discussionmentioning

confidence: 97%

Heart rate variability comparison between young males after 4–6 weeks from the end of SARS-CoV-2 infection and controls

Soliński

Pawlak

Petelczyc

et al. 2022

Sci Rep

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show abstract

“…These outcomes agree with another study, where insomnia was referred to as “coronasomnia/COVID-somia”. Together with sleep fragmentation and nightmares, it became more frequent in the general population during the COVID-19 pandemic [ 42 ]. Interestingly, in a French study conducted by Kokou–Kpolou et al, in which diagnostic criteria for insomnia were met by 19.1% of the respondents, results were similar to the outcomes from the Italian population [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Mental Health Interest and Its Prediction during the COVID-19 Pandemic Using Google Trends

Sycińska-Dziarnowska

Szyszka-Sommerfeld

Kłoda³

et al. 2021

IJERPH

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This study aimed to analyze and predict interest in mental health-related queries created in Google Trends (GT) during the COVID-19 pandemic. The Google Trends tool collected data on the Google search engine interest and provided real-time surveillance. Five key phrases: “depression”, “insomnia”, ”loneliness”, “psychologist”, and “psychiatrist”, were studied for the period from 25 September 2016 to 19 September 2021. The predictions for the upcoming trend were carried out for the period from September 2021 to September 2023 and were estimated by a hybrid five-component model. The results show a decrease of interest in the search queries “depression” and “loneliness” by 15.3% and 7.2%, respectively. Compared to the period under review, an increase of 5.2% in “insomnia” expression and 8.4% in the “psychiatrist” phrase were predicted. The expression “psychologist” is expected to show an almost unchanged interest. The upcoming changes in the expressions connected with mental health might be explained by vaccination and the gradual removal of social distancing rules. Finally, the analysis of GT can provide a timely insight into the mental health interest of a population and give a forecast for a short period trend.

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“…The symptoms of COVID-19 patients are varied, with the most common being fever, cough, digestive tract symptoms, sleep disorders and headaches, which are often treated by medication (Guan et al, 2020a;Bhat and Chokroverty, 2021;Fernández-De-Las-Peñas et al, 2021). Ibuprofen and acetaminophen are the most commonly used antipyretics.…”

Section: Symptomatic and Supportive Treatmentmentioning

confidence: 99%

The Role of Cytochrome P450 Enzymes in COVID-19 Pathogenesis and Therapy

et al. 2022

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Coronavirus disease 2019 (COVID-19) has become a new public health crisis threatening the world. Dysregulated immune responses are the most striking pathophysiological features of patients with severe COVID-19, which can result in multiple-organ failure and death. The cytochrome P450 (CYP) system is the most important drug metabolizing enzyme family, which plays a significant role in the metabolism of endogenous or exogenous substances. Endogenous CYPs participate in the biosynthesis or catabolism of endogenous substances, including steroids, vitamins, eicosanoids, and fatty acids, whilst xenobiotic CYPs are associated with the metabolism of environmental toxins, drugs, and carcinogens. CYP expression and activity are greatly affected by immune response. However, changes in CYP expression and/or function in COVID-19 and their impact on COVID-19 pathophysiology and the metabolism of therapeutic agents in COVID-19, remain unclear. In this analysis, we review current evidence predominantly in the following areas: firstly, the possible changes in CYP expression and/or function in COVID-19; secondly, the effects of CYPs on the metabolism of arachidonic acid, vitamins, and steroid hormones in COVID-19; and thirdly, the effects of CYPs on the metabolism of therapeutic COVID-19 drugs.

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Sleep disorders and COVID-19

Cited by 104 publications

References 107 publications

Heart rate variability comparison between young males after 4–6 weeks from the end of SARS-CoV-2 infection and controls

Heart rate variability comparison between young males after 4–6 weeks from the end of SARS-CoV-2 infection and controls

Mental Health Interest and Its Prediction during the COVID-19 Pandemic Using Google Trends

The Role of Cytochrome P450 Enzymes in COVID-19 Pathogenesis and Therapy

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