<p>Ocular Complications After Radiation Therapy: An Observational Study</p>

Abstract

The study aims to quantify the incidence of ocular complications in patients irradiated on the head and neck area in our medical center, stratified by type of neoplasm and radiation dose received. Materials and Methods: From an existing database of patients radio-treated in our center, we selected 25 patients irradiated in the 2011-2018 period. The patients had been treated for orbital lymphoma, nasopharyngeal carcinoma and cranial base meningioma. The selected patients received an ophthalmologic evaluation which included a complete ophthalmological and orthoptic assessment. Results: Our results showed a significantly higher incidence of DES (dry eye syndrome) and corneal complications for eyes receiving a Dmax higher than 40 Gy, as well as for cataract incidence in eyes that had received a Dmax to the lens higher than 5 Gy. We found an overall thinning of the RNFL (retinal nerve fiber layer) in eyes that had received a Dmax higher than 50 Gy, as well as a greater MD (mean deviation) from normal visual field values. Conclusion: In conclusion, we can say that the study confirms the presence of a correlation between the received radiation dose and the onset of eye complications, despite the small sample.

A Case Report of Inferior Oblique Reattachment after Inferomedial Orbital Wall Reconstruction from Total Maxillectomy

“…We also expected diplopia after the radiotherapy as there had been documented cases of diplopia after irradiation of head and neck tumors. 12 However, the extraocular muscles were involved in the reported cases.…”

Gamma Knife Radiosurgery for Indirect Dural Carotid–Cavernous Fistula: Long-Term Ophthalmological Outcome

“…The onset of radiation-induced cataract is extremely common, occurring at latency of 2 or 3 years, with an interval of 6 to 64 months [ 44 ]. Taking into account the wide range of dose and fractionation (from 8% to 83% depending on the characteristics of the treatment), it is difficult to estimate the actual incidence of radiation-induced cataract [ 45 ]. In general, a maximum of 2 Gy on the lens is the critical dosage for developing cataract [ 45 ].…”

“…Taking into account the wide range of dose and fractionation (from 8% to 83% depending on the characteristics of the treatment), it is difficult to estimate the actual incidence of radiation-induced cataract [ 45 ]. In general, a maximum of 2 Gy on the lens is the critical dosage for developing cataract [ 45 ]. However, in some studies, radiation dosage as low as 0.5 Gy still has a detrimental effect on cataracts development [ 46 , 47 ].…”

Intra-arterial infusion chemotherapy in the treatment of advanced basosquamous carcinoma of the nose

“…In addition, because one of the manifestations of radiation toxicity is decreased visual acuity among patients who are irradiated on the head region, radiation therapy was not performed in this patient. 8 Cisplatin-based chemotherapy has been reported to produce long-term remissions following treatment of advanced BCC. 9 However, cisplatin is a well-known chemotherapeutic agent with nephrotoxic potential.…”