Intra-arterial infusion chemotherapy in the treatment of advanced basosquamous carcinoma of the nose

Sheen, Yen-Ting; Sheen, Maw-Chang; Sheu, Hamm Ming; Sheen, Yi‐Shuan

doi:10.1016/j.jdcr.2021.06.018

Cited by 3 publications

(6 citation statements)

References 10 publications

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“…As far as concerns chemotherapy (CT) for laBSC and mBSC, there is no currently approved regimen. According to the literature, advanced BSCs were treated with a combination of paclitaxel and carboplatin 11,17 and intraarterial cisplatin (10 mg weekly for each carotid for 4 months, 400 mg in total) 12 . In general, CT was used after HHIs therapy, with the exception of one case (CT was preferred to vismodegib because the HHI was not reimbursed) 12 .…”

Section: Resultsmentioning

confidence: 99%

“…Finally, as far as concern chemotherapy, this option could be useful in some cases and according to the reports, platin‐based regimens (with or without paclitaxel) are preferred 11,12,17 …”

Section: Discussionmentioning

confidence: 99%

“…21 Finally, as far as concern chemotherapy, this option could be useful in some cases and according to the reports, platin-based regimens (with or without paclitaxel) are preferred. 11,12,17 In addition, it is necessary to underline that surgery and RT could also be combined or used in association with other therapeutic choices, in order to improve the outcome. 16,18,19 Table 2 summarizes a treatment recommendation proposal for laBSC and mBSC (in absence of therapy contraindication), however an extensive multidisciplinary discussion of each case is always essential.…”

Section: Discussionmentioning

confidence: 99%

“…12 In general, CT was used after HHIs therapy, with the exception of one case (CT was preferred to vismodegib because the HHI was not reimbursed). 12 CT was well tolerated and allowed to obtain CR in 2 patients (follow-up data lacking).…”

Section: Chemotherapymentioning

confidence: 99%

“…According to the literature, advanced BSCs were treated with a combination of paclitaxel and carboplatin 11,17 and intraarterial cisplatin (10 mg weekly for each carotid for 4 months, 400 mg in total). 12 In general, CT was used after HHIs therapy, with the exception of one case (CT was preferred to vismodegib because the HHI was not reimbursed). 12 CT was well tolerated and allowed to obtain CR in 2 patients (follow-up data lacking).…”

Section: Chemotherapymentioning

confidence: 99%

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Treatment of locally advanced and metastatic basosquamous carcinoma, navigating among sonic hedgehog pathway inhibitors, immune checkpoint inhibitors, chemotherapy, and radiotherapy: A case series and literature review

Zelin,

Mazzoletti,

Cavallo

et al. 2023

Aust J Dermatology

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Locally advanced (laBSCs) and metastatic basosquamous carcinomas (mBSCs) represent a therapeutic challenge. By definition, these forms are not amenable to surgery or radiotherapy, but according to literature reports, sonic hedgehog pathway inhibitors (HHIs), anti‐programmed death 1 receptor antibodies (anti‐PD‐1), and other treatment approaches involving chemotherapy, surgery, and radiotherapy have been used. This work features 5 real‐life cases of advanced BSCs, treated at the Dermato‐Oncology Unit of Trieste (Maggiore Hospital, University of Trieste). In addition, a review of the current treatment options reported in the literature for laBSC and mBSC is provided, collecting a total of 17 patients. According to these preliminary data, HHIs such as sonidegib and vismodegib could represent a safe and effective first line of treatment, while the anti‐PD‐1 cemiplimab may be useful as a second‐line option. Chemotherapy and combined approaches involving surgery and radiotherapy have been also reported to be suitable in some patients.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Chemotherapymentioning

confidence: 99%

Section: Chemotherapymentioning

confidence: 99%

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Treatment of locally advanced and metastatic basosquamous carcinoma, navigating among sonic hedgehog pathway inhibitors, immune checkpoint inhibitors, chemotherapy, and radiotherapy: A case series and literature review

Zelin,

Mazzoletti,

Cavallo

et al. 2023

Aust J Dermatology

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Basosquamous Carcinoma: Comprehensive Clinical and Histopathological Aspects, Novel Imaging Tools, and Therapeutic Approaches

Murgia,

Denaro,

Boggio

et al. 2023

Cells

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Basosquamous carcinoma (BSC), an uncommon and aggressive nonmelanoma skin cancer exhibiting characteristics ranging from basal cell carcinoma (BCC) to squamous cell carcinoma (SCC), is a subject of controversy in terms of its classification, pathogenesis, histologic morphology, biologic behavior, prognosis, and management. This narrative review is based on an electronic search of English-language articles in PubMed that included the terms “basosquamous carcinoma” and/or “metatypical carcinoma of the skin” in their titles. The review aims to succinctly present and assess current data on the epidemiology, clinical presentation, dermoscopic, LC-OCT, and histopathologic characteristics, as well as the genetics and management of BSC, providing insight into this intriguing entity. As a conclusion, dermoscopy, deep incisional biopsies, and immunohistologic techniques should be applied in clinically suspicious lesions to achieve an early diagnosis and better prognosis of this tumor. Surgical treatments, including wide excision and Mohs’ micrographic surgery, remain the treatment of choice. Finally, Hedgehog pathway inhibitors and checkpoint inhibitors, must be thoroughly investigated with large controlled trials, since they may offer an alternative solution to irresectable or difficult-to-treat locally advanced cases of basosquamous carcinoma.

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Squamous cell carcinoma of the auricle treated by intra-arterial infusion chemotherapy

Lin

Sheen

et al. 2021

Dermatol Sin

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Intra-arterial infusion chemotherapy in the treatment of advanced basosquamous carcinoma of the nose

Cited by 3 publications

References 10 publications

Treatment of locally advanced and metastatic basosquamous carcinoma, navigating among sonic hedgehog pathway inhibitors, immune checkpoint inhibitors, chemotherapy, and radiotherapy: A case series and literature review

Treatment of locally advanced and metastatic basosquamous carcinoma, navigating among sonic hedgehog pathway inhibitors, immune checkpoint inhibitors, chemotherapy, and radiotherapy: A case series and literature review

Basosquamous Carcinoma: Comprehensive Clinical and Histopathological Aspects, Novel Imaging Tools, and Therapeutic Approaches

Squamous cell carcinoma of the auricle treated by intra-arterial infusion chemotherapy

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