&lt;p&gt;Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats&lt;/p&gt;

Liang, Feng; Wang, Jianli; Zhu, Xiangyu; Wang, Zhen; Zheng, Jingwei; Sun, Zeyu; Xu, Shenbin; Zhang, Jianmin; Zhou, Jingyi; Shi, Ligen

doi:10.2147/dddt.s257333

Cited by 8 publications

(9 citation statements)

References 41 publications

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“… 32 Neuronal mitochondria damage may be another mechanism of hyperglycemia in hemorrhagic neural injury. 33 Aquaporin-4 (AQP4) is the most abundant aquaporin in the brain. 34 Our previous studies demonstrated that AQP4 reduces brain edema, BBB disruption, and apoptosis and aggravates hematoma expansion after ICH using AQP4 knockout mice.…”

Section: Discussionmentioning

confidence: 99%

The stress hyperglycemia ratio predicts early hematoma expansion and poor outcomes in patients with spontaneous intracerebral hemorrhage

Chu

Huang

Tang

et al. 2022

Ther Adv Neurol Disord

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Background: Different from diabetic hyperglycemia, stress-induced hyperglycemia (SIH) can better reflect elevated blood glucose owing to intracerebral hemorrhage (ICH). However, studies about the outcome of ICH patients with SIH are still very limited. Aims: This study aimed to investigate whether SIH measured by stress-induced hyperglycemia ratio (SHR) was associated with hematoma expansion and poor outcomes in patients with ICH. Methods: A consecutive series of patients with spontaneous ICH from two clinical centers admitted within 24 h after symptom onset were enrolled for prospective analysis. SHR was defined as admission fasting blood glucose divided by estimated average glucose [1.59 × Hemoglobin A1c (%) − 2.59]. This study investigated the association between SHR and hematoma expansion, and short-term and long-term poor outcomes using univariate and multivariate logistic regression analyses. Results: A total of 313 ICH patients were enrolled in the study. SHR was markedly higher in patients with hematoma expansion and poor outcomes ( p < 0.001). The multivariate logistic regression analysis demonstrated SHR independently associated with hematoma expansion ( p < 0.001) and poor outcomes, including secondary neurological deterioration within 48 h, 30-day mortality, and 3-month poor modified Rankin Scale (mRS 4–6) ( p < 0.001), while the blood glucose only predicted 30-day mortality. Meanwhile, the diagnostic accuracy of SHR exhibited by area under the curve in receiver operating characteristic analysis was statistically equal to or higher than the well-known predictors. Conclusion: SHR is a reliable predictor for early hematoma expansion and poor outcomes in patients with ICH.

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Section: Discussionmentioning

confidence: 99%

The stress hyperglycemia ratio predicts early hematoma expansion and poor outcomes in patients with spontaneous intracerebral hemorrhage

Chu

Huang

Tang

et al. 2022

Ther Adv Neurol Disord

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“…14 Group-C was given the same medication as Group-B, along with melatonin (10mg of melatonin/kg/day) in drinking water. 15 After one week of treatment, the female rats were allowed to mate and conceive. The treatment of all groups continued throughout the period of pregnancy and lactation.…”

Section: Methodsmentioning

confidence: 99%

Does melatonin protect fetal brain during maternal hypothyroidism? An experimental study

Hidayat

Saleemi²

2022

Pak J Med Sci

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Objectives: To study the effects of melatonin in preventing neonatal neuronal apoptosis induced by maternal hypothyroidism. Methods: Twelve healthy female Wistar rats, 12-16 weeks, were divided equally into three groups. Group-A was labelled as control. Group-B was made hypothyroid by giving 15mg/kg of propylthiouracyl (PTU) daily whereas Group-C was given PTU along with melatonin (10mg of melatonin/kg/day) in drinking water. After one week of treatment, the female rats were allowed to mate and conceive. The treatment of all groups continued throughout the period of pregnancy and lactation. After delivery, a total of 30 pups, 10 from each group, were labelled and sacrificed on 22nd day of life. The serum levels of TSH, T3 and T4 of the pups were measured. The brains were extracted from the skull and homogenized for isolation of mitochondria to determine the levels of cytochrome c oxidase and for isolation of RNAs to measure the levels of gene expressions of caspases 3, 9 and 8. Results: Group-B pups showed a significant increase in serum levels of TSH (21 ± 3.7 mg/dl), and gene expression levels of caspase 3 (0.85±0.02) and 9 (0.69±0.02) where as in Group-C, there was visible reduction in concentration of TSH (15 ± 2.4 mg/dl), caspase 3 (0.50±0.02) and 9 (0.25±0.01) expressions. Increase in cytochrome c oxidase enzyme concentration (3.416 ± 0.001) in Group-B was the result of mitochondrial outer membrane rupture, causing decrease in the number of neurons by accelerating apoptosis. A decrease in its level in Group-C (2.100 ± 0.001) indicated inhibition of apoptosis. Conclusion: Intake of melatonin during pregnancy and lactation protected the brains of offspring from extensive apoptosis during maternal hypothyroidism. doi: https://doi.org/10.12669/pjms.38.5.5536 How to cite this:Hidayat M, Saleemi MA. Does melatonin protect fetal brain during maternal hypothyroidism? An experimental study. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5536 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Melatonin is also known to minimize myelin sheath vacuolization, separation of axon-myelin sheaths, and degeneration of fibers. Though melatonin does not affect the insulin levels directly in DNP rats, it is known to increase brain antioxidant levels and potentiate the beneficial effects of insulin in DNP rats ( Gurel-Gokmen et al, 2018 ; Liang et al, 2020 ).…”

Section: Effect Of Melatonin Treatment On Diabetic Neuropathy In Expe...mentioning

confidence: 99%

“…It is estimated that 50% of diabetic patients suffer from DNP, with symptoms involving pain, foot ulcers, and amputation. Oxidative stress and neuroinflammation are known to play an important role in the pathogenesis of DNP ( Liang et al, 2020 ). The high prevalence of DNP in diabetic patients results from multiple reasons.…”

Section: Melatonin and Its Functions In Diabetic Neuropathymentioning

confidence: 99%

New Advances on Pathophysiology of Diabetes Neuropathy and Pain Management: Potential Role of Melatonin and DPP-4 Inhibitors

et al. 2022

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Pre-diabetes and diabetes are growing threats to the modern world. Diabetes mellitus (DM) is associated with comorbidities such as hypertension (83.40%), obesity (90.49%), and dyslipidemia (93.43%), creating a substantial burden on patients and society. Reductive and oxidative (Redox) stress level imbalance and inflammation play an important role in DM progression. Various therapeutics have been investigated to treat these neuronal complications. Melatonin and dipeptidyl peptidase IV inhibitors (DPP-4i) are known to possess powerful antioxidant and anti-inflammatory properties and have garnered significant attention in the recent years. In this present review article, we have reviewed the recently published reports on the therapeutic efficiency of melatonin and DPP-4i in the treatment of DM. We summarized the efficacy of melatonin and DPP-4i in DM and associated complications of diabetic neuropathy (DNP) and neuropathic pain. Furthermore, we discussed the mechanisms of action and their efficacy in the alleviation of oxidative stress in DM.

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<p>Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats</p>

Cited by 8 publications

References 41 publications

The stress hyperglycemia ratio predicts early hematoma expansion and poor outcomes in patients with spontaneous intracerebral hemorrhage

The stress hyperglycemia ratio predicts early hematoma expansion and poor outcomes in patients with spontaneous intracerebral hemorrhage

Does melatonin protect fetal brain during maternal hypothyroidism? An experimental study

New Advances on Pathophysiology of Diabetes Neuropathy and Pain Management: Potential Role of Melatonin and DPP-4 Inhibitors

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