&lt;p&gt;Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial&lt;/p&gt;

Foumani, Ali Alavi; Mehrdad, Mojtaba; Jafarinezhad, Alireza; Nokani, Khadijeh; Jafari, Alireza

doi:10.2147/copd.s207400

Cited by 32 publications

(39 citation statements)

References 23 publications

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“…For example, Bai and Dai ( 39 ) proposed that increased serum vitamin A and 25-hydroxyvitamin D3 (25OHD 3 ) levels can reflect the lung function and quality of life of asthmatic children. Vitamin D supplementation can improve the quality of life of patients with chronic pulmonary obstruction ( 40 ). In this study, quality of life scores were observed and counted in the RG and CG.…”

Section: Discussionmentioning

confidence: 99%

Clinical effect of vitamin�D supplementation on patients with pulmonary tuberculosis and its influence on the expression of immune cells and inflammatory factors

Cheng¹,

Pan²,

Li³

et al. 2020

Exp Ther Med

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Tuberculosis is highly infectious and has a high incidence worldwide. Therefore, effective treatment is essential for the disease. The immune function and inflammatory factors can reflect the therapeutic effect of pulmonary tuberculosis to some extent. Thus, the aim of the present study was to investigate the clinical effect of vitamin D supplementation on pulmonary tuberculosis patients and its influence on the expression of immune cells and inflammatory factors in patients. A total of 256 patients with pulmonary tuberculosis who were admitted to our hospital were collected as research participants; 120 patients who were treated with conventional antituberculosis drugs were taken as a control group (CG) and 136 patients who were treated with vitamin D-assisted antituberculosis drugs were taken as the research group (RG). The levels of inflammatory factors (IL-6, MMP-9, IL-4, TNF-α) and T lymphocyte subgroup of patients were measured in both groups before and after treatment. The efficacy was compared in both groups. The disappearance time of wheezing and cough in RG was shorter than that in CG (P<0.001). There was no difference in X-ray chest plain film, sputum examination results and efficacy of patients in both groups (P>0.05). After treatment, CD3 + , CD4 + , CD4 + /CD8 + were upregulated in both groups (P<0.05), while CD3 + , CD4 + , CD4 + /CD8 + in RG were higher than those in CG (P<0.05). After treatment, inflammatory factors in both groups improved compared with those before treatment. Serum inflammatory factors in RG were significantly lower than those in CG (P<0.05). After treatment, surfactant protein in the two groups was lower than that before treatment, while that in RG was significantly lower than that in CG (P<0.05). After treatment, soluble selectins in both groups improved significantly. The level of soluble selectins in RG was slightly lower than that in CG. The incidence of adverse reactions in RG was lower than that in CG. The life quality scores of patients in RG were slightly higher than those in CG (P<0.05). In conclusion, vitamin D-assisted antituberculosis drugs can effectively improve the immune function and expression level of inflammatory factors in pulmonary tuberculosis patients and reduce adverse reactions.

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Section: Discussionmentioning

confidence: 99%

Clinical effect of vitamin�D supplementation on patients with pulmonary tuberculosis and its influence on the expression of immune cells and inflammatory factors

Cheng¹,

Pan²,

Li³

et al. 2020

Exp Ther Med

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“…Both single high dose intramuscular and oral supplemental vitamin D seems to have beneficial effects on health-related quality of life [ 42 , 38 ]. We could not find many trials on mortality or disease prognosis as a primary outcome.…”

Section: Reviewmentioning

confidence: 99%

“…But later on, many studies showed similar results as Lehouck et al and added to the hypothesis that people with low serum 25(OH)D levels benefit more from supplemental vitamin D [ 31 , 42 , 43 ]. Many authors attributed their failure to obtain the desired outcome to either inclusion of vitamin D sufficient samples or the exclusion of vitamin D deficient COPD patients [ 37 , 38 , 41 ]. Other than vitamin D deficient or insufficient population, ever smokers with hypovitaminosis D or asthma/COPD are the groups who can get more benefits from the use of vitamin D as a therapeutic agent [ 35 ].…”

Section: Reviewmentioning

confidence: 99%

“…Gharabaghi et al and Sluyter et al reported improved FEV1 in subgroups like vitamin D insufficient population(10-30 ng/mL) and ever smokers, particularly with lung diseases (asthma, COPD) or vitamin D deficiency respectively [32,35]. In contrast, many studies showed no significant benefits of giving supplemental vitamin D to improve lung functions [36][37][38]. Older people with obstructive lung diseases and decreased 25(OH)D levels often need rehabilitation exercise to improve their muscle strength and physical activity.…”

Section: Clinical Trials Demonstrating the Role Of Supplemental Vitammentioning

confidence: 99%

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A Comprehensive Review on Vitamin D as a Novel Therapeutic Agent in Chronic Obstructive Pulmonary Disease

Saleem¹,

Sharif²,

Jarvis³

et al. 2021

Cureus

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Vitamin D has been playing an important role in the treatment of lung diseases. The non-calcemic effects of this vitamin and its role in chronic obstructive pulmonary disease (COPD) has drawn significant attention recently. Many studies have been conducted to explore the relationship between the two. We tested the hypothesis that vitamin D can act as an effective therapeutic agent for COPD by reviewing the correlation between the two and effectiveness along with the safety of supplemental vitamin D when used to treat chronic bronchitis and emphysema through clinical trials. An electronic search was conducted using combinations of keywords “vitamin D” and “COPD” from PubMed and Google scholar. Only relevant, human studies of all types were included from the last decade. A total of 36 articles were selected for review. Observational studies indicate a correlation between low serum 25(OH)D levels and obstructive lung disease pathology as well as clinical outcomes. Moreover, clinical trials were aimed to understand the impact of the use of vitamin D in improving disease indexes. These clinical trials used different drug regimes, mode of administration, and intervention duration with contrasting outcomes. Hypovitaminosis D is a common and harmful variant of this group of obstructive lung diseases, and correcting this deficiency can improve exacerbations, inflammation, lung functions, symptoms, and quality of life. These benefits are more prevalent in patients with low baseline serum 25 hydroxyvitamin D(25(OH)D) levels. Peroral is the most frequently used route of drug administration, however, further work is required to explore the pharmacological properties of vitamin D. There was not enough literature available about the safety of the drug of intervention.

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“…Though limited by their small sample size, some randomized controlled trials have reported improvements in exacerbations, 6-minute walk distance, or symptoms as measured by the COPD Assessment Test. [41,42] Longitudinal cohorts of COPD populations similarly demonstrate increased exacerbations, accelerated FEV1 decline, and higher symptom burden in association with lower vitamin D levels. [43] Our study had several other important limitations.…”

Section: Association Between Obstructive Lung Disease and Serum 25(oh)dmentioning

confidence: 99%

Serum Vitamin D Levels Are Not Associated with Obstructive Lung Disease in the General Population: An NHANES Analysis (2007-2008 to 2009-2010)

Seedahmed

Baugh

Kempker

2020

Preprint

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BackgroundObstructive lung disease is a significant cause of morbidity and healthcare burden within the United States. A growing body of evidence has suggested that vitamin D levels can influence the course or incidence of obstructive lung disease. However, there is an insufficient previous investigation of this association.Study Design and MethodsWe used the National Health and Nutrition Examination Survey (NHANES) cycles 2007-2008 and 2009-2010 spirometry results of individuals aged 40 years and older to assess the association between serum 25(OH)D levels and obstructive lung disease, as defined by the American Thoracic Society using the lower limit of normal (LLN). We used stage multivariate survey-logistic regression with backward selection.ResultsThe final model included body mass index, pack-years smoking history, and ethnicity. In the primary model, there was no association between vitamin D levels and obstructive lung disease. We noted an association between “Other Hispanic” self-identified race and serum Vitamin D levels wherein higher levels were associated with higher odds of obstructive lung disease in this ethnicity, but not among other racial or ethnic groups (OR= 1.48, p= 0.02).ConclusionsSerum Vitamin D levels among adults are not associated with the odds of obstructive lung disease in the general population. Results among non-Mexican Hispanic participants highlight the need for further research in minority populations. More work is needed to address the course and incidence of lung disease in the United States.RESEARCH IN CONTEXTWhat is the key question?In the general population, is there an independent association between Vitamin D and obstructive lung disease after controlling for relevant covariates?What is the bottom line?In exploring whether serum vitamin D levels are associated with odds of obstructive lung disease in the general US population, we did not find an independent association in the overall sample.Why read on?This paper adds nuance to the broad understanding of vitamin D’s role in lung pathophysiology.

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<p>Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial</p>

Cited by 32 publications

References 23 publications

Clinical effect of vitamin�D supplementation on patients with pulmonary tuberculosis and its influence on the expression of immune cells and inflammatory factors

Clinical effect of vitamin�D supplementation on patients with pulmonary tuberculosis and its influence on the expression of immune cells and inflammatory factors

A Comprehensive Review on Vitamin D as a Novel Therapeutic Agent in Chronic Obstructive Pulmonary Disease

Serum Vitamin D Levels Are Not Associated with Obstructive Lung Disease in the General Population: An NHANES Analysis (2007-2008 to 2009-2010)

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