A Comprehensive Review on Vitamin D as a Novel Therapeutic Agent in Chronic Obstructive Pulmonary Disease

Saleem, Amber; Sharif, Shayka; Jarvis, Sommer; Madouros, Nikolaos; Koumadoraki, Evgenia; Khan, Safeera

doi:10.7759/cureus.13095

Cited by 5 publications

(4 citation statements)

References 43 publications

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“…The European Society of Parenteral and Enteral Nutrition (ESPEN) also made a definition in 2016 by considering patients with and without systemic inflammation in two different malnutrition subcategories based on biochemical inflammatory markers [7]. COPD is an inflammatory condition of the respiratory system that causes airway obstruction, and it is known that there is an increase in serum inflammatory marker levels in patients with COPD [8][9][10][11]. However, the relationship between inflammatory markers and nutritional status in patients with COPD is an issue that needs to be investigated in the literature.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Nutritional Status in Hospitalized Chronic Obstructive Pulmonary Disease Patients and Can C-reactive Protein-to-Albumin Ratio Be Used in the Nutritional Risk Assessment in These Patients

Baldemir¹,

Öztürk²,

DOĞANAY³

et al. 2022

Cureus

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BackgroundMalnutrition is common in patients diagnosed with chronic obstructive pulmonary disease (COPD). CRP/albumin ratio (CAR) can be used as a parameter to evaluate the inflammatory process and nutritional status together. The aim of this study was to make a general evaluation of the nutritional status of hospitalized patients with COPD and to investigate whether CAR can predict nutritional status in these patients. MethodsPatients who were hospitalized with COPD who were consulted to the nutrition department were included in the study. The patients' Nutritional Risk Score-2002 (NRS), demographic data, diagnoses, body mass indexes (BMI), nutritional support applied to the patients were recorded. CRP, Albumin, and CAR values of the patients were determined. Patients recommended nutritional follow-up, total parenteral nutrition (TPN) or enteral nutrition (EN) initiated, and oral nutritional supplement (ONS) support were identified. ResultsA total of 393 patients with COPD were analyzed. 88.55% of the patients were in the NRS ≥ 3 risk group. TPN treatment was started in 10.2% of the patients, EN in 10.9%, ONS in 76.3%, and nutritional follow-up was recommended in 2.5% of the patients. While albumin level was lower in patients with NRS ≥ 3, CRP and CAR were higher in patients with NRS ≥ 3 (p < 0.05). There was a negative correlation between NRS-2002 and albumin (p < 0.001). A positive correlation was observed between NRS-2002 and CRP and CAR (p < 0.001). Age and CAR were found to be effective in predicting those with NRS-2002 ≥ 3. The cut-off value for CAR was accepted as 3.26. ConclusionsThe need for nutritional support is high in patients hospitalized with COPD. It is important to evaluate nutritional support needs in these patients, regardless of NRS-2002 and BMI. In this respect, the clinician's observation and the decision are as valuable as the scoring that determines malnutrition. We think that the cut-off value of 3.26 determined for CAR can be used in the nutritional risk assessment in patients with COPD.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Nutritional Status in Hospitalized Chronic Obstructive Pulmonary Disease Patients and Can C-reactive Protein-to-Albumin Ratio Be Used in the Nutritional Risk Assessment in These Patients

Baldemir¹,

Öztürk²,

DOĞANAY³

et al. 2022

Cureus

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“…Previous studies prove that vitamin D plays a role in improving lung function and improving quality of life but with a longer study time than that of this study. [42][43][44] Nonetheless, this study succeeds in revealing the benefits of administering vitamin D at a high dose of 5,000 IU for just three months in reducing oxidative stress levels, as evidenced by the significant reduction in MDA and MMP-9 levels. It will be very beneficial in the management of COPD to prevent the progression of the disease.…”

Section: Discussionmentioning

confidence: 71%

Mechanism of High Dosage Vitamin D Supplementation on The Lung Function and Quality of Life of Stable COPD Patients

Donastin¹,

Amin²,

Yulistiani³

2023

Pharmacogn J.

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Background: Oxidative stress results from the amplification mechanism of COPD, which leads to decreased lung function and the quality of life of the sufferers. Vitamin D has a function in reducing oxidative stress levels through several mechanisms, which can be revealed by analyzing several biomarkers to determine the role of vitamin D on lung function and the quality of life of stable COPD patients. Methods: The subjects included GOLD 2 and 3 stable COPD patients who had 25(OH)D levels of < 32 ng/ml and were receiving bronchodilator Indacaterol maleate therapy. The biomarkers examined included Nrf2, HDAC2, MDA, MMP-9, pulmonary function tests 6MWT, and QOL. The patients in the control and treatment groups were administered with vitamin D at a dose of 1,000 and 5,000 IU, respectively, for three months. Results: The administration of vitamin D to the patients in the control and treatment groups can significantly reduce oxidative stress, as evidenced by reduced MDA (p-value < 0.01) and MMP-9 levels (p-value < 0.01). Vitamin D affects exercise tolerance, as evidenced by 6MWT (p-value = 0.01). Vitamin D affects the quality of life, as evidenced by 6MWT (p-value = 0.01). Vitamin D affects Nrf2 levels (p-value = 0.08) and HDAC2 (p-value = 0.01). Conclusion: The pathway analysis through the study of the Nrf2, HDAC2, MMP-9, and MDA levels does not prove that vitamin D can prevent decreased lung function and quality of life in patients with stable COPD.

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“…Additionally, intake of glucocorticoids increases the metabolic breakdown of vitamin D. Furthermore, the natural course of COPD involves mechanisms such as inflammatory response, decreased liver potential activation function, decreased gastrointestinal absorption functions, and vitamin D being blocked in adipose tissue, all of which can lead to metabolic disorders of vitamin D in patients with COPD. 53,54 Physical activity may ameliorate the aforementioned disturbances through various mechanisms. High levels of inflammation in COPD patients, often associated with insufficient physical activity, 35 can be mitigated by regular exercise training.…”

Section: Discussionmentioning

confidence: 99%

Effects of physical activity and sedentary behavior on serum vitamin D in patients with chronic obstructive pulmonary disease

Wang,

Ge,

Zhang

et al. 2024

Adv Clin Exp Med

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Background. Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous disease with multiple extrapulmonary manifestations, among which vitamin D deficiency and insufficiency are very common in COPD and are associated with the health status and clinical outcomes of COPD patients.Objectives. This paper aims to analyze the impact of leisure-time physical activity (LTPA) and daily sitting time (DST) and their interactions on serum vitamin D in patients with COPD. Materials and methods.Participants aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES) in the USA from 2007 to 2012 who had undergone pulmonary function tests and vitamin D tests were selected as the study participants. Participants' LTPA and DST were assessed using the General Practice Assessment Questionnaire (GPAQ). Multivariate logistic regression analysis was used to analyze the relationship between serum vitamin D, LTPA, DSA and the combination of the 2 in patients with COPD, and the results were expressed as odds ratio (OR) and 95% confidence interval (95% CI).Results. This study included 1,448 samples. The mean vitamin D concentration of the samples was (68.27 ±26.78) nmol/L; 360 participants (24.86%) had vitamin D deficiency and 539 participants (37.22%) had vitamin D insufficiency. Vitamin D and 25(OH)D3 expression levels differed across the 4 groups (150 min/week and DST > 8 h revealed the highest vitamin D expression levels, while LTPA 8 h showed the lowest. Vitamin D was weakly correlated with FEV 1 , FVC, BMI, age, and LTPA (p < 0.01), but not with DST. Body mass index (BMI) was weakly positively correlated with DST (r = 0. 142, p < 0.01). Conclusions.Serum physical activity and DST independently affect vitamin D levels in COPD patients; therefore, increasing physical activity and minimizing DST may help improve vitamin D levels and prevent vitamin D deficiency.

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A Comprehensive Review on Vitamin D as a Novel Therapeutic Agent in Chronic Obstructive Pulmonary Disease

Cited by 5 publications

References 43 publications

Evaluation of Nutritional Status in Hospitalized Chronic Obstructive Pulmonary Disease Patients and Can C-reactive Protein-to-Albumin Ratio Be Used in the Nutritional Risk Assessment in These Patients

Evaluation of Nutritional Status in Hospitalized Chronic Obstructive Pulmonary Disease Patients and Can C-reactive Protein-to-Albumin Ratio Be Used in the Nutritional Risk Assessment in These Patients

Mechanism of High Dosage Vitamin D Supplementation on The Lung Function and Quality of Life of Stable COPD Patients

Effects of physical activity and sedentary behavior on serum vitamin D in patients with chronic obstructive pulmonary disease

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