<p>Higher Dietary Inflammatory Index Scores are Associated with Increased Odds of Benign Breast Diseases in a Case–Control Study</p>

Abstract

Purpose: Dietary inflammatory index (DII) is a new tool for assessing the inflammatory potential of diet. Since there is no study that has investigated the association of DII and benign breast diseases (BBD), the aim of our study was to compare DII scores in patients with and without BBD. Methods: One hundred and eleven (111) subjects with BBD and 104 healthy women attending the Iranian Center for Breast Cancer affiliated with the Academic Center for Education, Culture and Research were enrolled in a case-control study. Dietary data collected using a 168-item validated food frequency questionnaire (FFQ). Energy-adjusted DII was calculated based on FFQ. Socio demographic data were collected by interview. In addition, physical activity was measured by the International Physical Activity Questionnaire (IPAQ). Weight, height and waist circumference were also measured. Results: After adjustment for multiple confounding variables, participants at the highest tertile of DII had increased OR for BBD (OR=1.7, 95% CI=0.75-3.95) (P-trend =0.04). Conclusion: The increased chance of BBD was suggested with a higher consumption of diets with inflammatory potential. However, this result should be interpreted with caution as OR was not statistically significant. Interventional studies are warranted to elucidate the role of inflammatory diets in the development of BBD.

The association between inflammatory and immune system biomarkers and the dietary inflammatory index in patients with COVID-19

“…Dietary intake of MUFAs was only positively related to DII and not E-DII. In a study by Aghababayan et al, only dietary intakes of total fat, cholesterol, and SFA were significantly higher in the upper tertile of DII (58). In another study, dietary intakes of carbohydrates, fibers, and PUFAs were higher in the lowest tertile of DII; however, dietary intakes of cholesterol, SFAs, and MUFAs were higher in the third quartile of DII (59).…”

Association of Weight Indicators, Dietary Habits, and Physical Activity With Common Benign Breast Diseases

“…Boeke et al 32 disclosed a positive association with alcohol and a negative association between nuts and BBD. Aghababayan et al 33 approached the issue of nutrients and BBD from another perspective. In one study, 33 they calculated the dietary inflammatory index in the diets of patients and showed a probable direct association with using higher amounts of foods with inflammatory potential.…”

“…Aghababayan et al 33 approached the issue of nutrients and BBD from another perspective. In one study, 33 they calculated the dietary inflammatory index in the diets of patients and showed a probable direct association with using higher amounts of foods with inflammatory potential. In a second study, 34 they considered the dietary phytochemical index of the diets and showed an inverse association with BBD.…”

Strong association between the dietary inflammatory index(DII) and breast cancer: a systematic review and meta-analysis

“…Accordingly, a subgroup analysis that only included the cohort studies revealed a more moderate association between the DII and breast cancer risk. Aside from the studies included in this meta-analysis, one previous study found no association between the DII and breast cancer-specific deaths [ 24 ], while Aghababayan et al [ 25 ] reported a possible association between the DII and benign breast tumors.…”