Strong association between the dietary inflammatory index(DII) and breast cancer: a systematic review and meta-analysis

Chen, Huajian; Gao, Yuzhe; Wei, Na; Du, Kuiying; Jia, Qi

doi:10.18632/aging.202985

Cited by 13 publications

(12 citation statements)

References 25 publications

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“…In recent years, the associations between DII and sitespecific cancers have been reported (14)(15)(16)(17)36). Hua et al and Zhu et al conducted two systematic reviews and dose-response meta-analyses on DII and upper aerodigestive tract cancer (UADT) (23,24).…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the associations between DII and site-specific cancers have been reported ( 14 – 17 , 36 ). Hua et al.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, DII has been implicated in the occurrence and development of several types of cancer, such as breast cancer, colorectal cancer, and gastric cancer ( 14 – 17 ). There were also existing literature examining the relationship between DII and oral cancer ( 18 – 22 ).…”

Section: Introductionmentioning

confidence: 99%

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Association between dietary inflammatory index and oral cancer risk: A systematic review and dose–response meta-analysis

Luo

Zhu

et al. 2022

Front. Oncol.

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BackgroundDietary inflammatory index (DII) has been suggested to be associated with oral cancer risk. However, a quantitative comprehensive assessment of the dose–response relationship has not been reported. We performed a meta-analysis to clarify the risk of oral cancer with DII.MethodsWe searched PubMed, Embase, Cochrane Library, and Web of Science databases for relevant articles published up to 1 March 2022. Fixed- or random-effects models were utilized to estimate the pooled odds ratio (OR) of oral cancer with DII, as appropriate. Restricted cubic splines were used to model the dose–response relationship.ResultsWe included five case–control studies involving 1,278 cases and 5,137 controls in the meta-analysis. Risk of oral cancer was increased by 135% with the highest versus lowest DII level [OR: 2.35, 95% confidence interval (CI): 1.88–2.94], and 79% with higher versus lower DII level (OR: 1.79, 95% CI: 1.49–2.15). We found no evidence of a nonlinear dose–response association of DII with oral cancer (pnon-linearity = 0.752), and the risk was increased by 17% (OR: 1.17, 95% CI: 1.05–1.30) with 1 unit increment in DII score.ConclusionThis meta-analysis suggested that a higher DII score was associated with increased risk of oral cancer. Therefore, reducing pro-inflammatory components and promoting anti-inflammatory components of diet may be effective in the prevention of oral cancer.

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Section: Discussionmentioning

confidence: 99%

“…In recent years, the associations between DII and site-specific cancers have been reported ( 14 – 17 , 36 ). Hua et al.…”

Section: Discussionmentioning

confidence: 99%

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Association between dietary inflammatory index and oral cancer risk: A systematic review and dose–response meta-analysis

Luo

Zhu

et al. 2022

Front. Oncol.

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“…Nevertheless, as indicated in a recent meta-analysis, several studies have produced null results for the DII in association with BrCA. 56 Previous studies have shown that adherence to healthy dietary patterns such as the Healthy Eating Index, 57 the Dietary Approach to Stop Hypertension, 58 and the Mediterranean Diet 59 are associated with a decreased risk of BrCA. Higher scores based on these indices, which are consistently inversely related to the DII/E-DII, indicate more anti-inflammatory diets.…”

Section: Discussionmentioning

confidence: 99%

“…Consistently, large case‐control studies in Italian 30 and Chinese women 31 have shown that the DII is positively associated with the risk of BrCA. Nevertheless, as indicated in a recent meta‐analysis, several studies have produced null results for the DII in association with BrCA 56 . Previous studies have shown that adherence to healthy dietary patterns such as the Healthy Eating Index, 57 the Dietary Approach to Stop Hypertension, 58 and the Mediterranean Diet 59 are associated with a decreased risk of BrCA.…”

Section: Discussionmentioning

confidence: 99%

The association between the inflammatory potential of diet and the risk of histopathological and molecular subtypes of breast cancer in northwestern Iran: Results from the Breast Cancer Risk and Lifestyle study

Hayati

Montazeri

Shivappa

et al. 2022

Cancer

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BACKGROUND:This study explored the association between diet-associated inflammation and the risk of different molecular subtypes of breast cancer (BrCA) in a large, population-based case-control study conducted in northwestern Iran. METHODS: The study consisted of 1007 women with histopathologically confirmed BrCA and 1004 controls admitted to hospitals in Tabriz, northwestern Iran, for nonneoplastic conditions. Dietary Inflammatory Index scores and energy-adjusted Dietary Inflammatory Index (E-DII) scores, with and without supplements, were computed on the basis of dietary intake collected using a validated 136-item food frequency questionnaire. RESULTS: Women with the highest E-DII scores (quartile 4) versus those with the lowest E-DII scores (quartile 1) showed a significantly increased BrCA risk (odds ratio for quartile 4 vs quartile 1 [OR Q4vsQ1 ], 1.87; 95% confidence interval [CI], 1.42-2.47), particularly for lobular carcinoma (OR Q4vsQ1 , 3.07; 95% CI, 1.34-7.02). Findings were similar for premenopausal women diagnosed with luminal A BrCA (OR Q4vsQ1 , 2.71; 95% CI, 1.74-4.22) or luminal B BrCA (OR Q4vsQ1 , 2.86; 95% CI, 1.39-5.89). Women consuming the most proinflammatory diets were 3 times more likely to have triple-negative BrCA (OR Q4vsQ1 , 3.00; 95% CI, 1.002-8.96) while compared to luminal A BrCA. The BrCA risk for women consuming diets in the highest half of E-DII scores (E-DII > 0) was 59% greater than the risk for those in the lowest half (95% CI, 1.29-1.97). Also, higher E-DII scores that took into account supplements were associated with larger tumor sizes (T3 > 5 cm; P < .05). CONCLUSIONS: A proinflammatory diet, as indicated by higher E-DII scores, appears to increase the risk of BrCA in Iranian women. Large increases in risk were seen in invasive molecular subtypes of BrCA. Anti-inflammatory diets are suggested to prevent the risk of overall BrCA and more aggressive forms of BrCA in particular.

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Higher Dietary Inflammatory Index and Increased Mortality Rate of Adults With Hyperuricemia: Findings From the National Health and Nutritional Examination Survey (2001–2018)

Zhou,

Cai,

Xiao

et al. 2024

Arthritis Care & Research

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ObjectiveThis study aimed to assess the association between Dietary Inflammatory Index (DII) score and mortality among adults with hyperuricemia.MethodsWe collected data from the 2001‐2018 cohorts of the National Health and Nutritional Examination Surveys (NHANES). Mortality information was obtained based on death certificate records from the National Death Index (NDI) through 31 December 2019. The associations between DII score and all‐cause, cardiovascular disease (CVD) and cancer mortality were investigated by using Cox proportional hazards regression models.ResultsWe enrolled 7786 participants with hyperuricemia in this study. The DII score ranged from −4.42 to 4.61. Higher DII score was significantly associated with higher levels of BMI, glycohemoglobin, glucose, LDL‐cholesterol and CRP (all P <0.05). During 67851 person‐years of follow‐up, 1456 participants were identified death including 532 CVD deaths and 246 cancer deaths. After adjusted for potential variables, significant higher risk of all‐cause (HR:1.18, 95% CI: 1.03, 1.36, P =0.01) and CVD (HR:1.30, 95% CI: 1.03, 1.63, P =0.02) mortality was observed for individuals with higher DII score. Considering the DII score as a continuous variable, the risk of all‐cause and CVD mortality increases 5% (HR:1.05, 95% CI: 1.01, 1.08) and 8% (HR:1.08, 95% CI: 1.02, 1.15) with each one‐unit increment in DII, respectively. Subgroup analysis indicated that the association between DII and all‐cause mortality among hyperuricemia participants was more significant in male.ConclusionDII score is found positively associated with all‐cause and CVD mortality of adults with hyperuricemia. Controlling the intake of pro‐inflammatory food might be potential strategy to reduce mortality.

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Strong association between the dietary inflammatory index(DII) and breast cancer: a systematic review and meta-analysis

Cited by 13 publications

References 25 publications

Association between dietary inflammatory index and oral cancer risk: A systematic review and dose–response meta-analysis

Association between dietary inflammatory index and oral cancer risk: A systematic review and dose–response meta-analysis

The association between the inflammatory potential of diet and the risk of histopathological and molecular subtypes of breast cancer in northwestern Iran: Results from the Breast Cancer Risk and Lifestyle study

Higher Dietary Inflammatory Index and Increased Mortality Rate of Adults With Hyperuricemia: Findings From the National Health and Nutritional Examination Survey (2001–2018)

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