&lt;p&gt;Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells&lt;/p&gt;

Li, Haitao; Zhi, Yunlai; Ma, Chunyan; Shen, Qianqian; Sun, Fanghu; Cai, Chengkuan

doi:10.2147/cmar.s273826

Cited by 18 publications

(16 citation statements)

References 33 publications

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“…Previously, many studies have reported miR-615-5p served as a tumor promoter in several tumors ( Guan et al, 2019 ; Godínez-Rubí and Ortuño-Sahagún, 2020 ). In PCa, miR-615-5p was shown to suppress the ability of proliferation and metastasis of tumor cells ( Li et al, 2020 ). We also observed that the proliferation and metastasis of PCa cells were hindered by miR-615-5p overexpression.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, more and more studies confirmed that TRIP13 was frequently highly expressed in many types of tumors, including PCa ( Zhang et al, 2019 ; Wang et al, 2020b ; Chen et al, 2020 ). Functionally, several studies reported that TRIP13 overexpression promoted PCa cells’ proliferation and metastasis ( Chen et al, 2020 ; Li et al, 2020 ). In this study, we found that TRIP13 may be a target of miR-615-5p, as further demonstrated by luciferase reporter assays.…”

Section: Discussionmentioning

confidence: 99%

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Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p

Zeng

Liu

Yang

et al. 2021

Front. Mol. Biosci.

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Objective: This study was conducted for investigating the functions of circular RNA circRNA_100146 (circRNA_100146) in the development of prostate cancer (PCa) and identifying the underlying mechanisms of the circRNA_100146/miR-615-5p/TRIP13 axis.Materials and Methods: Under the support of RT-PCR, the expression of circRNA_100146 in PCa cells was examined. Cell Counting Kit-8 (CCK-8) assays and clone formation assays were applied to the assessment of cell proliferation. We then determined cell invasion and migration through transwell assays and wound healing assays. RNA pull-down assays and luciferase reporter assays were performed for the exploration of the regulatory effects of potential molecules on the expressions of the targeting genes. In addition, a nude mouse xenograft model was applied to demonstrate the oncogenic roles of circRNA_100146 in PCa.Results: CircRNA_100146 expression was distinctly upregulated in PCa cells. Silencing of circRNA_100146 suppressed PCa cells’ invasion, migration, and proliferation. CircRNA_100146 sponged miR-615-5p to suppress its expressions, while miR-615-5p targeted the 3’-UTR of TRIP13 to repress the expression of TRIP13. In addition, we observed that knockdown of miR-615-5p reversed the suppression of circRNA_100146 silence on the proliferation and invasion of PCa cells. In addition, the tumor growth was also suppressed by silencing circRNA_100146 in vivo.Conclusion: CircRNA_100146 is a tumor promoter in PCa, which promoted progression by mediating the miR-615-5p/TRIP13. CircRNA_100146 can be a potential candidate for targeted therapy of PCa.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p

Zeng

Liu

Yang

et al. 2021

Front. Mol. Biosci.

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“…In recent years, circRNAs have also been found to participate in the progression of tumor drug resistance. In prostate cancer, circ_0062020 overexpression promoted the expression level of thyroid hormone receptor‐interacting protein 13 ( TRIP13 ) via sponging miR‐615‐5p [ 146 ]. NHEJ signaling pathway was thus actuated, leading to enhanced DNA repair and decreased drug sensitivity of tumor cells [ 147 ].…”

Section: Functions and Mechanisms Of Ncrnas In Drug Resistance Of Osccmentioning

confidence: 99%

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

Meng¹,

Lou

Yang³

et al. 2021

Cancer Communications

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Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises from the interaction of multiple factors including tobacco, alcohol consumption, and betel quid. Chemotherapeutic agents such as cisplatin, 5‐fluorouracil, and paclitaxel have now become the first‐line options for OSCC patients. Nevertheless, most OSCC patients eventually acquire drug resistance, leading to poor prognosis. With the discovery and identification of non‐coding RNAs (ncRNAs), the functions of dysregulated ncRNAs in OSCC development and drug resistance are gradually being widely recognized. The mechanisms of drug resistance of OSCC are intricate and involve drug efflux, epithelial‐mesenchymal transition, DNA damage repair, and autophagy. At present, strategies to explore the reversal of drug resistance of OSCC need to be urgently developed. Nano‐delivery and self‐cellular drug delivery platforms are considered as effective strategies to overcome drug resistance due to their tumor targeting, controlled release, and consistent pharmacokinetic profiles. In particular, the combined application of new technologies (including CRISPR systems) opened up new horizons for the treatment of drug resistance of OSCC. Hence, this review explored emerging regulatory functions of ncRNAs in drug resistance of OSCC, elucidated multiple ncRNA‐meditated mechanisms of drug resistance of OSCC, and discussed the potential value of drug delivery platforms using nanoparticles and self‐cells as carriers in drug resistance of OSCC.

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“… 91 2020 circSLC19A1 hsa_circ_0062019 up miR-326 MAPK1 promoted the proliferation, migration, and invasion of PCa cells 48 pairs of PCa tissues and adjacent normal tissues; DU145, PC3, LNCaP, 22RV1, and RWPE-1 cell lines Huang 92 2020 circ_0062020 hsa_circ_0062020 up miR-615-5p – promoted cell proliferation, migration, and invasion; inhibited apoptosis and radiosensitivity 30 radiosensitive PCa samples, 30 radioresistant PCa samples and 30 normal prostate tissues; DU145, LNCaP, and WPMY-1cell lines Li et al. 93 2020 circRNA17 hsa_circ_0001427 down miR-181c-5p ARv7 inhibited cell enzalutamide resistance and invasion 26 PCa samples and 13 normal prostate tissues; C4–2, CWR22Rv1, and 293T cell lines Wu et al. 94 2019 circSMAD2 hsa_circ_0047603 down miR-9 STAT and MEK/ERK pathways inhibited cell proliferation and migration; blocked EMT process 20 pairs of PCa tissues and adjacent normal tissues; LNCaP and PC3 cell lines Han et al.…”

Section: Functions and Mechanisms Of Circrnas In Pcamentioning

confidence: 99%

Circular RNAs in prostate cancer: Biogenesis, biological functions, and clinical significance

Liu

Tong

Ding

et al. 2021

Molecular Therapy - Nucleic Acids

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Circular RNAs (circRNAs) are covalently closed RNA molecules that play important regulatory roles in various tumors. Prostate cancer (PCa) is one of the most common malignant tumors in the world, with high morbidity and mortality. In recent years, more and more circRNAs have been found to be abnormally expressed and involved in the occurrence and development of PCa, including cell proliferation, apoptosis, invasion, migration, metastasis, chemotherapy resistance, and radiotherapy resistance. Most of the circRNAs regulate biological behaviors of cancer through a competitive endogenous RNA (ceRNA) regulatory mechanism, and some can exert their functions by binding to proteins. circRNAs are also associated with many clinicopathological features of PCa, including tumor grade, lymph node metastasis, and distant metastasis. In addition, circRNAs are potential diagnostic and prognostic biomarkers for PCa. Considering their critical regulatory roles in the progression of PCa, circRNAs would be the potential therapeutic targets. In this paper, the current research status of circRNAs in PCa is briefly reviewed.

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<p>Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells</p>

Cited by 18 publications

References 33 publications

Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p

Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

Circular RNAs in prostate cancer: Biogenesis, biological functions, and clinical significance

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