“…Research in the field of cancer treatment increased significantly in finding a drug or an effective way to stop tumors with no side effects (Azhar et al, 2021), miRNA which is a new class of small non-coding RNA molecules that pair with the 3′ non-coding region of target mRNA, resulting in the deterioration of the mutated mRNA or inhibition of translation, thus controlling and increasing the level of some other people (Fu et al, 2020;Josson et al, 2014), Cancer is usually caused by mutation, and this mutation causes damage to the cellular gene and depresses the tumor protected gene, such as P53, with an increase in other mutagenic proteins (A Al-Hassany et al, 2021;Fu et al, 2020). It is a miRNA with a tumor suppressor effect discovered in recent years and has been found in different types of tumors, such as gastric cancer , bladder and prostate cancer (Yuan et al, 2019;Zhang et al, 2020). Down-regulation of expression targets a variety of genes to regulate tumor proliferation, invasion, and spreading metastases (Bagherian et al, 2021).…”