LINC01087 indicates a poor prognosis of glioma patients with preoperative MRI

Abstract

Long intergenic non-coding RNA 01,087 (LINC01087) has been concerned as an oncogene in breast cancer, while its mechanism in glioma has been little surveyed. Thus, we searched the prognostic value and functional action of LINC01087 in glioma. Glioma patients after preoperative MRI diagnosis were enrolled, and LINC01087, microRNA (miR)-1277-5p, and alkaline ceramidase 3 (ACER3) levels were tested in glioma cancer tissue. The correlation between LINC01087 expression and the survival of patients were analyzed. LINC01087, miR-1277-5p, and ACER3 levels in U251 cells were altered via transfection, and cell malignant phenotypes were monitored. The relationship between miR-1277-5p and LINC01087 or ACER3 was detected. The LINC01087 and ACER3 expression was in up-regulation and the miR-1277-5p expression was in down-regulation in clinical glioma samples. High expression of LINC01087 was associated with poor prognosis of glioma patients with preoperative MRI. LINC01087 silencing restrained tumor malignancy in glioma cells. Mechanistically, LINC01087 directly interacted with miR-1277-5p. ACER3 was a known target of miR-1277-5p. Moreover, rescue assays reveal that miR-1277-5p overexpression (or ACER3 overexpression) reversed the effects of LINC01087 upregulation (or miR-1277-5p upregulation) on glioma cells. LINC01087 has prognostic significance in glioma and silencing LINC01087 deters glioma development through elevating miR-1277-5p to reduce ACER3 expression.

Systematic Investigation of the Diagnostic and Prognostic Impact of LINC01087 in Human Cancers

“…Our results were consistent with the literature regarding the abundance of LINC01087 in BC and ESCA [ 36 , 37 , 38 , 68 ]. Nevertheless, previous research reported a higher expression of LINC01087 in THCA patients than in normal individuals [ 38 ], which was not validated in this study.…”

“…The long intergenic non-coding RNA 01087 (LINC01087) is a recently described lncRNA whose function remains poorly investigated. The contribution of LINC01087 to the pathogenesis of cancer, as well as its pivotal role as a biomarker, has been described only in a few oncological indications (i.e., BC, glioma, esophageal squamous cell carcinoma, and thyroid cancer) [ 32 , 36 , 37 , 38 , 39 ]. Recent evidence reported LINC01087 to be overexpressed in glioma patients with respect to healthy subjects [ 36 , 37 ].…”

“…The contribution of LINC01087 to the pathogenesis of cancer, as well as its pivotal role as a biomarker, has been described only in a few oncological indications (i.e., BC, glioma, esophageal squamous cell carcinoma, and thyroid cancer) [ 32 , 36 , 37 , 38 , 39 ]. Recent evidence reported LINC01087 to be overexpressed in glioma patients with respect to healthy subjects [ 36 , 37 ]. Mechanistically, it has been demonstrated that LINC01087 participates in the development of glioma by targeting some microRNAs (miRNAs) (i.e., miR-384 and miR-1277-5p) and, therefore, altering the related signaling pathways [ 36 , 37 ].…”

“…Recent evidence reported LINC01087 to be overexpressed in glioma patients with respect to healthy subjects [ 36 , 37 ]. Mechanistically, it has been demonstrated that LINC01087 participates in the development of glioma by targeting some microRNAs (miRNAs) (i.e., miR-384 and miR-1277-5p) and, therefore, altering the related signaling pathways [ 36 , 37 ]. For instance, it has been demonstrated in vitro that a high expression of LINC01087 reduces the level of Bcl2 by acting as a miR-384 sponge, thus promoting apoptosis in glioma cells [ 36 ].…”

Bendlet Transform Based Adaptive Denoising Method for Microsection Images

“…), and glioma cells are tangled with surrounding tissue, resulting in glioma images with diffuse borders, etc. [ 22 ]. In order to better identify the glial tumor areas in MRI images, this study mainly used bendlet transform to make the images of glioma disease in the brain better retain the definition of texture of edges after denoising, and improved the efficiency of the identification of gliomas in the brain.…”