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Taken together, our data provide that SNHG3 has potential clinical value of and may serve as target of ovarian cancer treatment.

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Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR-382 has been observed in various types of cancers. However, the biological function of miRNA-382 in colorectal cancer (CRC) is still largely unknown. Here, we found that miR-382 was down regulated in human colorectal cancer tissues and cell lines associated with it. MiR-382 inhibited colorectal cancer cell proliferation, migration, invasion and enhance chemo sensitivity. Furthermore, we identified krueppel-like factor 12 (KLF12) and homeodomain-interacting protein kinase 3 (HIPK3) as the target of miR-382, miR-382 rescued the promotion effect of KFL12 on migration and enhance chemosensitivity in colorectal cancer cell lines. Collectively, these findings revealed that miR-382 inhibits migration、enhance chemosensitivity by targeting KLF12 and HIPK3 in colorectal cancer. These found might serve as a tumor suppressor in CRC.

Diffusion tensor imaging reflects the microstructure change of radiation-induced brain injury in the acute and subacute stage, which provides an objective basis for early intervention of potential irreversible brain injury in the late delayed stage, and has important significance for improving the overall efficacy of radiotherapy.