<p>Chromosomal Instability in Farmers Exposed to Pesticides: High Prevalence of Clonal and Non-Clonal Chromosomal Alterations</p>

Profile of Chromosomal Alterations, Chromosomal Instability and Clonal Heterogeneity in Colombian Farmers Exposed to Pesticides

“…In fact, one of the few available studies indicating the type and frequency of specific chromosomal alterations induced by pesticide exposure was reported by us, in a small group of exposed (five exposed) (Cepeda et al, 2020). In this study, we observed a significant increase in clonal and non-clonal chromosomal alterations in individuals exposed to pesticides compared to unexposed individuals (Cepeda et al, 2020). Considering the importance of our previous findings in the identification of cytogenetic biomarkers for the monitoring of exposed populations, we decided to conduct a new study with a greater number of individuals exposed to pesticides.…”

“…However, in these studies, the evaluation of chromosomal damage has been limited to the identification of chromosome gaps, breaks, sister chromatid exchange (Gomez-Arroyo et al, 2000) and micronuclei (MN), among others, so information on the type and frequency of specific CAs and chromosomal variants (CVs), as well as the level of chromosomal instability (CIN) and clonal heterogeneity (CH) induced by exposure to pesticides is scarce. In fact, one of the few studies available that indicate the type and frequency of specific chromosomal alterations induced by exposure to pesticides was reported by us, in a small group of exposed (five exposed) (Cepeda et al, 2020). Considering the importance of our previous findings (Cepeda et al, 2020) and their implications both, in the identification of cytogenetic biomarkers for the monitoring of exposed populations, and in the possibilities of their future application in early diagnostic tests, we decided to conduct a new study with a greater number of individuals exposed to pesticides.…”

“…In fact, one of the few studies available that indicate the type and frequency of specific chromosomal alterations induced by exposure to pesticides was reported by us, in a small group of exposed (five exposed) (Cepeda et al, 2020). Considering the importance of our previous findings (Cepeda et al, 2020) and their implications both, in the identification of cytogenetic biomarkers for the monitoring of exposed populations, and in the possibilities of their future application in early diagnostic tests, we decided to conduct a new study with a greater number of individuals exposed to pesticides. Considering the above, the aim of the present study was to evaluate the genotoxic damage (CAs, CVs, CIN and CH), in a group of thirty-four (34) farmers occupationally exposed to pesticides in the town of Simijacá, Colombia, and in a control group of thirty-four (34) unexposed individuals, by using GTG Banding and Fluorescence in situ hybridization (FISH).…”

Cancer and occupational exposure to pesticides: a bibliometric study of the past 10 years

“…For example, Cepeda et al ( 2020 ) warn that even though the factors associated with the development of the cancer are discussed, data on cancer types and their frequency are often lacking. It is important to note here that the monitoring of exposure to xenobiotics, such as pesticides, using biomarkers like the micronucleus test, is an essential tool for the early detection and prevention of diseases such as oral cancer (Tomiazzi et al 2018 ).…”

Asetamipridin Fare Kemik İliği Hücrelerinde KA (Kromozomal Aberasyon) ve MN (Mikronükleus) Test Yöntemleri ile Genotoksik Etkisinin Araştırılması

“…Pesticides have different levels of toxic effects on animals and humans other than agricultural pests as well. Therefore, it is necessary to evaluate the effects of pesticides not only with the organism which they affect, but also with the plants, human and other organisms in the area where they are applied (5)(6)(7).…”