<p>Antiacne and antiblotch activities of a formulated combination of <em>Aloe barbadensis</em> leaf powder, <em>Garcinia mangostana</em> peel extract, and <em>Camellia sinensis</em> leaf extract</p>

Abstract

Objective: We compared the efficacy of an antiacne hydrogel formulated with a combination of Aloe barbadensis leaf extract, Garcinia mangostana peel extract, and Camellia sinensis leaf extract (AGC) at a ratio of 50:25:1 with a marketed 1% clindamycin gel (CG) formulation on antiacne and antiblotch activities. Methods: A single-center, parallel-arm, randomized controlled trial was performed from November 2017 to April 2018. Sixty subjects with mild–moderate acne severity according to the the American Academy of Dermatology were enrolled for the study. Outcome end points were total acne lesions (TALs) and acne-severity index (ASI) by counting the inflamed lesions and comedones and skin colors using erythema and melanin values. Results: For TALss, a decrease ( P <0.0001) in the number of total inflamed lesions from baseline was evidenced in AGC group, but not in the CG group. Higher reduction in mean ASI in the AGC group was seen than in the CG group. However, there was no statistically significant difference regarding reduction in ASI between the AGC and CG groups. For erythema, a remarked reduction in skin redness from baseline was clearly seen at day 3 ( P <0.05) in the AGC group. No significant decrease in erythema values from baseline was seen in the CG group. A significant decrease ( P =0.037) in mean melanin value from baseline was seen in the AGC group after 14 days of twice-daily use, but not in the CG group. Both products were well tolerated, with no reports of severe adverse events. Conclusion: An anti-acne hydrogel containing a combination of mangosteen rinds, aloe vera gel, and green tea–leaf extracts was superior to 1% clindamycin gel in antiacne and antiblotch activities when measured by TALs and erythema and melanin values.

The effects of green tea on acne vulgaris: A systematic review and meta‐analysis of randomized clinical trials

“…Of note, a study by Waranuch et al (Waranuch et al, 2019) included in our meta-analysis showed that erythema and pigmentation were significantly improved by treatment with topical GTE solution compared to topical 1% clindamycin. Topical GTE application has been shown to prevent UV-induced erythema, leukocyte infiltration, and subsequent ROS generation, as well as reduce DNA damage from UV irradiation and the incidence of skin cancer in animal studies (Elmets et al, 2001;S K Katiyar et al, 1999).…”

“…In contrast, the only oral GTE study (Lu & Hsu, 2016) reported a slight but significant improvement in inflammatory lesions but no improvement was seen in non‐inflammatory lesions compared to the placebo controls. Waranuch et al (Waranuch et al, 2019) evaluated the total inflamed acne lesions and acne severity index along with erythema and melanin values in the topical GTE group and the therapeutic control group using 1% clindamycin gel. Neither total inflamed lesions nor acne severity index was significantly different between the topical GTE group and the control group.…”

“…Due to different characteristics of the controls (vehicle or therapeutic control), we generated separate Forest plots of the inflammatory acne lesions between the topical GTE group versus 1% clindamycin in the study by Waranuch et al (2019). The results indicated that topical GTE was not inferior to the therapeutic control, 1% clindamycin, for inflammatory lesions (Figure 3).…”

EFFEKTIFITAS OBAT HERBAL TERHADAP PENYEMBUHAN JERAWAT : A Systematic Review

“…Hidrogel anti jerawat yang mengandung kombinasi kulit manggis, gel lidah buaya, dan teh hijau, lebih unggul dari gel klindamisin 1% dalam aktivitas antiacne dan antiblotch bila diukur dengan nilai TALs, eritema dan melanin. 14 .…”

Rhodomyrtone as a New Natural Antibiotic Isolated from Rhodomyrtus tomentosa Leaf Extract: A Clinical Application in the Management of Acne Vulgaris

“…In recent decades, certain extracts of plants have been targeted as alternative therapeutic agents for acne treatment [ 15 ]. For example, pharmaceutical formulations with plant-derived antimicrobials, including Garcinia mangostana, [ 16 , 17 ] and Camellia sinensis [ 18 ], have been used as topical medicine with wide acceptance as cosmetic products. In addition, a number of purified natural compounds [ 19 ] and essential oils [ 15 ] derived from plants have been developed as anti-acne agents.…”