Rhodomyrtone as a New Natural Antibiotic Isolated from Rhodomyrtus tomentosa Leaf Extract: A Clinical Application in the Management of Acne Vulgaris

Abstract

Rhodomyrtone, a plant-derived principal compound isolated from Rhodomyrtus tomentosa (Myrtaceae) leaf extract, was assessed as a potential natural alternative for the treatment of acne vulgaris. The clinical efficacy of a 1% liposomal encapsulated rhodomyrtone serum was compared with a marketed 1% clindamycin gel. In a randomized and double-blind controlled clinical trial, 60 volunteers with mild to moderate acne severity were assigned to two groups: rhodomyrtone serum and clindamycin gel. The volunteers were instructed to apply the samples to acne lesions on their faces twice daily. A significant reduction in the total numbers of acne lesions was demonstrated in both treatment groups between week 2 and 8 (p < 0.05). Significant differences in acne numbers compared with the baseline were evidenced at week 2 onwards (p < 0.05). At the end of the clinical trial, the total inflamed acne counts in the 1% rhodomyrtone serum group were significantly reduced by 36.36%, comparable to 34.70% in the clindamycin-treated group (p < 0.05). Furthermore, a commercial prototype was developed, and a clinical assessment of 45 volunteers was performed. After application of the commercial prototype for 1 week, 68.89% and 28.89% of volunteers demonstrated complete and improved inflammatory acne, respectively. All of the subjects presented no signs of irritation or side effects during the treatment. Most of the volunteers (71.11%) indicated that they were very satisfied. Rhodomyrtone serum was demonstrated to be effective and safe for the treatment of inflammatory acne lesions.

TNF-α/TNFR1 activated astrocytes exacerbate depression-like behavior in CUMS mice

“…Users of antidepressive agents currently experience several adverse effects, such as weight gain, sexual dysfunction, and treatment resistance [ 4 , 44 , 45 ]. Studies have shown that Rho had the advantages of low drug resistance and toxicity [ 46 , 47 ], so Rho may be a promising antidepressant.…”

Wound Healing Potential of Rhodomyrtus tomentosa and its Bioactive Compounds- Rhodomyrtone

“…In the same year, the researcher developed a concise synthesis of the rhodomyrtone and isomeric acylphloroglucinols rhodomyrtosone B which displayed antibacterial activity [40]. Further research on rhodomyrtone proved the antibacterial properties and clinical management in Acne Vulgaris [41]. Recently, it was discovered that rhodomyrtone did not exhibit any toxicity in invertebrate or vertebrate models [42].…”

Synthesis of Rhodomyrtone Analogs Modified at C7

“…The group of Voravuthikunchai et al obtained promising results in a study against psoriasis [17] and rhodomyrtone showed comparable effects to a drug against acne vulgaris in a double-blind controlled clinical trial. [18] Despite a lot of research, the exact mode of action of rhodomyrtone was not known until recently. Work by Götz et al showed that rhodomyrtone is a membrane-active compound that can lead to a breakdown of the membrane potential and release of ATP and cytoplasmic proteins.…”

“…The group of Voravuthikunchai et al . obtained promising results in a study against psoriasis [17] and rhodomyrtone showed comparable effects to a drug against acne vulgaris in a double‐blind controlled clinical trial [18] . Despite a lot of research, the exact mode of action of rhodomyrtone was not known until recently.…”