&lt;p&gt;Acute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking&lt;/p&gt;

Soares, Viviane; Avelar, Ivan Silveira de; Venâncio, Patrícia Espíndola Mota; Pires-Oliveira, Deise A. A.; Silva, Pedro Henrique de Almeida; Borges, Amanda Rodrigues; Fonseca, Gustavo Paz Estevez Ferreira

doi:10.2147/jir.s281113

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…The post-exercise increase in IL-6 levels is well documented in existing literature [30][31][32][33][34][35]. It is worth emphasizing that IL-6 is one of the most rapidly produced myokines as a result of physical exercise, and its levels increase more dramatically than any other cytokine investigated to date [31].…”

Section: Discussionmentioning

confidence: 89%

The Effect of Submaximal Exercise Followed by Short-Term Cold-Water Immersion on the Inflammatory State in Healthy Recreational Athletes: A Cross-Over Study

Pawłowska

Mila-Kierzenkowska

Boraczyński

et al. 2021

JCM

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Cold-water immersion (CWI) after exercise is a method used by sportsmen to improve recovery. The aim of the study was to assess the effect of a 3 min CWI on the inflammatory state by measuring levels of interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor α (TNF-α), and transforming growth factor β1 (TGF-β1), and activities of α1-antitrypsin (AAT) and lysosomal enzymes, including arylsulfatase (ASA), acid phosphatase (AcP), and cathepsin D (CTS D), in the blood of healthy recreational athletes. Male volunteers (n = 22, age 25 ± 4.8 yr) performed a 30 min submaximal aerobic exercise, followed by a 20 min rest at room temperature (RT-REST) or a 20 min rest at room temperature with an initial 3 min 8 °C water bath (CWI-REST). Blood samples were taken at baseline, immediately after exercise, and after 20 min of recovery. The IL-6, IL-10, and TNF-α levels and the AAT activity increased significantly immediately after exercise. The IL-6 level was significantly higher after CWI-REST than after RT-REST. No changes in the activities of the lysosomal enzymes were observed. The effect of a 3 min CWI on the level of inflammatory markers during post-exercise recovery was limited. Thus, it might be considered as a widely available method of regeneration for recreational athletes.

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Section: Discussionmentioning

confidence: 89%

The Effect of Submaximal Exercise Followed by Short-Term Cold-Water Immersion on the Inflammatory State in Healthy Recreational Athletes: A Cross-Over Study

Pawłowska

Mila-Kierzenkowska

Boraczyński

et al. 2021

JCM

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“…It was available only in short period then excreted and found in the urine. Interleukin-6 level increased significantly an hours after exercise untill reach it peak at 6 hours after (Soares et al, 2020 andMorettini et al, 2017).…”

Section: Discussionmentioning

confidence: 90%

Serum Interleukin-6 Level Raise Up In Time With Muscle Soreness at 24 Hours Recovery From Vigorous Exercise: Does It Correlate ?

Teju¹,

Purwanto²,

Ayubi³

2022

IJRP

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Background : Muscle soreness or muscle pain occurs after long-term physical activity or after unusual exercise. Some explains it due to pro inflammatory cytokines secreted during and after exercise. Interleukin-6 and tumor necrotic factor alpha were two cytokines believed as promoting factor of muscle soreness. Until now, it was still unclear whether interleukin-6 or tumour necrotic factor alpha that correlate with the soreness found at 24 hours recovery from vigorous exercise. Purpose : This study was aimed to analyse the level of interleukin-6 and tumour necrotic factor alpha by time of 6-and 24-hour recovery from exercise. Method/Material: Correlation study research method with a cross-sectional research design. The subject of this study were twenty voluntary trained, healthy male, aged 20-30 years old with normal body mass index was randomly registered in this study. Subjects was grouped in vigorous exercised group and moderate exercised group as control. The blood was obtained from the subjects at 6 and 24 hours recovery post exercise for interleukin-6 and tumor necrotic factor alpha level measurement. Result : Was shown raised of pain intensity of muscle soreness and interleukin-6 level but not tumor necrotic alpha level. The interleukin-6 level correlated to the pain intensity of muscle soreness at 24 hours post exercise (P<0,05).

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“…Концентрация ИЛ-6 у молодых здоровых людей составляет в среднем 2,2 пг/мл; у людей в возрасте 70±10 лет -3,7 пг/мл [15].…”

Section: резюме _____________________________________________________...unclassified

Clinical and Pathogenetic Information Value of a Combined Study of Laboratory Indicators of Inflammatory and the State of Lipid Metabolism in Patients with Chronic Suppurative Otitis Media Involving Epitympanum

Юревич¹,

Шестакова²,

Муравейник³

2022

Лабораторная Диагностика. Восточная Европа

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Цель. Установить характер сочетанных изменений показателей биомаркеров воспаления и липидного (липопротеинового) спектра сыворотки крови как одного из потенциально возможных механизмов формирования хронического эпитимпаноантрального гнойного среднего отита (H66.2, МКБ-10).Материалы и методы. Для установления показателей лабораторных тестов, отражающих синдром воспаления и состояние липидного (липопротеинового) спектра сыворотки крови, проведено одномоментное когортное исследование контингента пациентов из 56 человек, включающего в себя 42 пациентов с диагнозом «хронический эпитимпано-антральный гнойный средний отит» (с холестеатомой и без) и 14 практически здоровых человек, составивших контрольную группу, которая по возрастно-половому составу соответствовала группе пациентов, страдающих гнойным отитом.Результаты. У всех пациентов выполнено количественное определение содержания в сыворотке крови интерлейкина-6, С-реактивного белка, общего холестерина, холестерина липопротеинов высокой плотности, холестерина липопротеинов низкой плотности, триацилглицеринов, апобелка-А, апобелка-В, липопротеина (а). Установлено, что показатели концентрации интерлейкина-6, липопротеина (а), апобелка-В и липопротеинов низкой плотности достоверно увеличены у пациентов с хроническим эпитимпано-антральным гнойным средним отитом с холестеатомой по сравнению с аналогичными значениями представителей контрольной группы пациентов (p<0,05).Выводы. Сочетанное исследование факторов воспаления и липидного спектра сыворотки крови показало увеличение ее атерогенного потенциала на фоне усугубления выраженности метаболических проявлений воспалительного процесса, что может являться важным патогенетическим звеном формирования холестеатомы и ее рецидивирования. Полученные данные являются основанием к проведению дальнейших исследований на предмет установления лабораторно-диагностической и прогностической значимости выявленных метаболических нарушений. Purpose. Determine the concentration levels of inflammation indicators (interleukin-6, C-reactive protein) and lipid spectrum of blood serum in patients with chronic suppurative otitis media involving epitympanum, both with and without cholesteatoma, who underwent surgical treatment at the Republican Scientific and Practical Center of Otorhinolaryngology from August to December 2021.Materials and methods. To establish the indicators of laboratory tests reflecting the inflammation syndrome and the state of the lipid (lipoprotein) spectrum of the blood serum, a one-stage cohort study of a contingent of patients of 56 people, including 42 patients with a diagnosis of "Chronic suppurative otitis media involving epitympanum" (with and without cholesteatoma) was carried out and 14 practically healthy people who made up the control group, which in terms of age and sex composition corresponded to the group of patients suffering from suppurative otitis media.Results. All patients underwent quantitative determination of serum levels of interleukin-6, C-reactive protein, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerols, apoprotein-A, apoprotein-B, lipoprotein (a). It was established that the concentrations of interleukin-6, lipoprotein (a), apoprotein-B and low-density lipoproteins were significantly increased in patients with chronic suppurative otitis media involving epitympanum with cholesteatoma compared with similar values in the control group of patients (p<0.05).Conclusions. It remains relevant to conduct further studies to establish the levels of interleukins and lipid spectrum indicators in order to identify markers-predictors of cholesteatoma recurrence in patients with chronic suppurative otitis media involving epitympanum.

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<p>Acute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking</p>

Cited by 9 publications

References 31 publications

The Effect of Submaximal Exercise Followed by Short-Term Cold-Water Immersion on the Inflammatory State in Healthy Recreational Athletes: A Cross-Over Study

The Effect of Submaximal Exercise Followed by Short-Term Cold-Water Immersion on the Inflammatory State in Healthy Recreational Athletes: A Cross-Over Study

Serum Interleukin-6 Level Raise Up In Time With Muscle Soreness at 24 Hours Recovery From Vigorous Exercise: Does It Correlate ?

Clinical and Pathogenetic Information Value of a Combined Study of Laboratory Indicators of Inflammatory and the State of Lipid Metabolism in Patients with Chronic Suppurative Otitis Media Involving Epitympanum

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