&lt;p&gt;A perspective on magnetic core&amp;ndash;shell carriers for responsive and targeted drug delivery systems&lt;/p&gt;

Albinali, Kholoud E.; Zagho, Moustafa M.; Deng, Yonghui; Elzatahry, Ahmed A.

doi:10.2147/ijn.s193981

Cited by 89 publications

(59 citation statements)

References 188 publications

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“…Poly(lactide-co-glycolic acid) (PLGA) is a biocompatible and biodegradable polymer, and its application for human use in drug delivery systems of various therapeutic agents has been approved by the US FDA (Food and Drug Administration) and EMA (European Medicines Agency) [ 50 , 51 ]. In recent years, PLGA–NP systems have been some of the most studied due to their capacity for encapsulating drugs and biomolecules for applications in drug delivery [ 52 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Neguț

Grumezescu

et al. 2020

Molecules

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Plant extracts are highly valuable pharmaceutical complexes recognized for their biological properties, including antibacterial, antifungal, antiviral, antioxidant, anticancer, and anti-inflammatory properties. However, their use is limited by their low water solubility and physicochemical stability. In order to overcome these limitations, we aimed to develop nanostructured carriers as delivery systems for plant extracts; in particular, we selected the extract of Anthriscus sylvestris (AN) on the basis of its antimicrobial effect and antitumor activity. In this study, AN-extract-functionalized magnetite (Fe3O4@AN) nanoparticles (NPs) were prepared by the co-precipitation method. The purpose of this study was to synthesize and investigate the physicochemical and biological features of composite coatings based on Fe3O4@AN NPs obtained by matrix-assisted pulsed laser evaporation technique. In this respect, laser fluence and drop-casting studies on coatings were performed. The physical and chemical properties of laser-synthesized coatings were investigated by scanning electron microscopy, while Fourier transform infrared spectroscopy comparative analysis was used for determining the chemical structure and functional integrity. Relevant data regarding the presence of magnetic nanoparticles as the only crystalline phase and the size of nanoparticles were obtained by transmission electron microscopy. The in vitro toxicity assessment of the Fe3O4@AN showed significant cytotoxic activity against human adenocarcinoma HT-29 cells after prolonged exposure. Antimicrobial results demonstrated that Fe3O4@AN coatings inhibit microbial colonization and biofilm formation in clinically relevant bacteria species and yeasts. Such coatings are useful, natural, and multifunctional solutions for the development of tailored medical devices and surfaces.

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Section: Introductionmentioning

confidence: 99%

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Neguț

Grumezescu

et al. 2020

Molecules

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“…This effect is expected since release depends on degradation of the polymeric drug carrier such as chitosan, which takes place in short time. Inorganic nanocarriers used in drug delivery systems (DDSs) for drugs and therapeutic agents have included mesoporous silica nanoparticles (MSNs), magnetic nanoparticles, zinc nanoparticles, and others to treat various diseases [30][31][32][33]. Hydroxyapatite is the primary inorganic component of teeth and bone.…”

Section: Introductionmentioning

confidence: 99%

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

et al. 2020

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Targeted drug delivery offers great opportunities for treating cancer. Here, we developed a novel anticancer targeted delivery system for piperine (Pip), an alkaloid prodrug derived from black pepper that exhibits anticancer effects. The tailored delivery system comprises aggregated hydroxyapatite nanoparticles (HAPs) functionalized with phosphonate groups (HAP-Ps). Pip was loaded into HAPs and HAP-Ps at pH 7.2 and 9.3 to obtain nanoformulations. The nanoformulations were characterized using several techniques and the release kinetics and anticancer effects investigated in vitro. The Pip loading capacity was >20%. Prolonged release was observed with kinetics dependent on pH, surface modification, and coating. The nanoformulations fully inhibited monolayer HCT116 colon cancer cells compared to Caco2 colon cancer and MCF7 breast cancer cells after 72 h, whereas free Pip had a weaker effect. The nanoformulations inhibited ~60% in HCT116 spheroids compared to free Pip. The Pip-loaded nanoparticles were also coated with gum Arabic and functionalized with folic acid as a targeting ligand. These functionalized nanoformulations had the lowest cytotoxicity towards normal WI-38 fibroblast cells. These preliminary findings suggest that the targeted delivery system comprising HAP aggregates loaded with Pip, coated with gum Arabic, and functionalized with folic acid are a potentially efficient agent against colon cancer.

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“…However, there are obstacles and challenges for using SPIONs, including their tendency to aggregation and the protein corona effect [ 10 , 11 , 12 , 14 ]. One of the most prevalent approaches used to meet these obstacles is coating the surface of nanoparticles with polymers [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Magnetic Nanoparticles by Folate as Potential MRI Contrast Agent for Breast Cancer Diagnostics

et al. 2020

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In recent years, the intrinsic magnetic properties of magnetic nanoparticles (MNPs) have made them one of the most promising candidates for magnetic resonance imaging (MRI). This study aims to evaluate the effect of different coating agents (with and without targeting agents) on the magnetic property of MNPs. In detail, iron oxide nanoparticles (IONPs) were prepared by the polyol method. The nanoparticles were then divided into two groups, one of which was coated with silica (SiO2) and hyperbranched polyglycerol (HPG) (SPION@SiO2@HPG); the other was covered by HPG alone (SPION@HPG). In the following section, folic acid (FA), as a targeting agent, was attached on the surface of nanoparticles. Physicochemical properties of nanostructures were characterized using Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and a vibrating sample magnetometer (VSM). TEM results showed that SPION@HPG was monodispersed with the average size of about 20 nm, while SPION@SiO2@HPG had a size of about 25 nm. Moreover, HPG coated nanoparticles had much lower magnetic saturation than the silica coated ones. The MR signal intensity of the nanostructures showed a relation between increasing the nanoparticle concentrations inside the MCF-7 cells and decreasing the signal related to the T2 relaxation time. The comparison of coating showed that SPION@SiO2@HPG (with/without a targeting agent) had significantly higher value in comparison to Fe3O4@HPG. Based on the results of this study, the Fe3O4@SiO2@HPG-FA nanoparticles have shown the best magnetic properties, and can be considered promising contrast agents for magnetic resonance imaging applications.

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<p>A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems</p>

Cited by 89 publications

References 188 publications

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

Functionalization of Magnetic Nanoparticles by Folate as Potential MRI Contrast Agent for Breast Cancer Diagnostics

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