&lt;i&gt;L&lt;/i&gt;-Dopa and the Secretion of Sebum in Parkinsonian Patients

Streifler, M; Avrami, E.; Rabey, J. M.

doi:10.1159/000115127

Cited by 9 publications

(7 citation statements)

References 10 publications

(14 reference statements)

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“…Bass et al (9) found weak positive correlation of sebum secretion with hypokinesia and rigidity, but not with tremor. Streifler et al (12) found no significant correlation between sebum secretion and clinical disability.…”

Section: Discussionmentioning

confidence: 96%

Sebum secretion in idiopathic Parkinson's disease: effect of anticholinergic and dopaminergic drugs

Villares

Carlini

1989

Acta Neurologica Scandinavica

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Sebum secretion was measured on the foreheads of 47 unmedicated patients with idiopathic Parkinson's disease, aged 50-81 years and 80 healthy, matched volunteers. Sebum secretion was significantly higher in men patients aged 50-59 years than in controls; no such difference was observed in women of the same age. There was also no difference between patients and volunteers of either gender older than 60 years of age. The effects of either biperiden, L-Dopa + benserazide (a decarboxylase inhibitor) or bromocriptine treatments on sebum secretion and on 5 parkinsonian signs were evaluated over 127 days. There was a significant reduction of all measures during the treatment with the dopaminergic drugs. The only observable effect with biperiden was reduction of tremor. It is discussed whether the sebum suppressive effect of the dopaminergic drugs may be explained through their central effects.

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Section: Discussionmentioning

confidence: 96%

Sebum secretion in idiopathic Parkinson's disease: effect of anticholinergic and dopaminergic drugs

Villares

Carlini

1989

Acta Neurologica Scandinavica

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“…There are controversies concerning L-dopa effects on sebum excretion of Parkinsonian patients: some studies have reported a reducing effect (Agache and Blanc, 1982;Sparavigna et al, 1993) supporting the idea that seborrhea is accompanied by the blockade of a permanent inhibiting factor on sebum secretion, usually under brain dopamine control (Streifler et al, 1980;Harville and Appenzeller, 1978). Other authors have not yet found any effects (Plewig and Kligman, 1978), and many variations in the individual responses to L-dopa have been described.…”

Section: Discussionmentioning

confidence: 99%

“…At the beginning of the '70s, the first parkinsonian patient treated with L-dopa showed a reduction of seborrhea (Shuster and Thody, 1974;Streifler et al, 1980) suggesting that the disease was accompanied by the blockade of a permanent inhibiting factor on SER, usually under central dopaminergic control. In subsequent years a small number of studies concerning seborrhea have been published, the results of which are difficult to compare, due to the different methods used and the small number of subjects examined (Agache and Blanc, 1982;Villares and Carlini, 1989).…”

Section: Introductionmentioning

confidence: 99%

Is seborrhea a sign of autonomic impairment in Parkinson's disease?

Martignoni

Godi

Pacchetti

et al. 1997

J. Neural Transmission

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An increase of sebum excretion rate (SER) is frequently observed in patients suffering from Parkinson's disease (PD). Some authors attribute it to the hyperactivity of the parasympathetic system, while others consider the possible action of androgens or of MSH-hormone. The aim of our study was to verify and quantify SER in 70 parkinsonian patients and compare it with SER in 60 normal subjects. We found higher values of SER in male subjects, both in normal and in parkinsonian patients. The highest rate of excretion was observed in parkinsonian males, in agreement with the possible main role of androgens or testosterone in sebum excretion, while the phenomenon did not appear to be related to abnormalities of the autonomic nervous system. The association of PD and sex hormones might therefore be crucial for the developing of seborrhea.

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“…Confirmam-se portanto, as observações de Streifler et al 27 e Agnoli et al 2 . Em relação ao sexo feminino a terapêutica não foi efetiva, provavelmente, em decorrência do pequeno número de avaliados.…”

Section: Comentáriosunclassified

L-dopa, biperideno e excreção sebácea na doença de Parkinson

Villares

1989

Arq. Neuro-Psiquiatr.

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RESUMO -A excreção sebácea frontal de 47 parkinsonianos «de novo» antes e após tratamento com anticolinérgico (biperideno), levodopa + IDAA e bromocriptina foi avaliada pelo método do ácido ósmico. Outros 100 parkinsonianos sob terapêutica crônica com biperideno, levodopa + IDAA ou associação de ambos foram avaliados. Parkinsonianos «de novo» do sexo masculino apresentam valores de excreção sebácea significativamente mais elevados em relação às mulheres. Verificou-se que biperideno não foi eficaz em reduzir o grau de excreção sebácea. Já, em relação a L-dopa + IDAA constatou-se que a droga foi efetiva em reduzir o grau de excreção sebácea (NC e TRE) tanto no sexo masculino quanto no feminino. Em relação à bromocriptina (l0mg/dia) também constatou-se que houve redução da excreção sebácea no sexo masculino. Correlação significante positiva foi verificada entre o NC, tremor, bradicinesia, hipertonia, alterações da marcha e postura e incapacidade funcional, entre parkinsonianos do sexo masculino e faixa etária 50-59 anos, no período pré-tratamento. Após o período de tratamento não mais havia correlação entre excreção sebácea e as manifestações neurológicas da doença de Parkinson. Entre parkinsonianos sob terapêutica crônica verificou-se correlação positiva e significante entre excreção sebácea e bradicinesia. O grau de excreção sebácea de parkinsonianos «de novo» sem tratamento não difere do grau daqueles sob tratamento crônico, exceção feita a parkinsonianos com idade > 60 anos, em que verificou-se maior grau de excreção sebácea (NC e TRE) em relação ao mesmo sexo e faixa etária, sem tratamento. L-dopa + IDAA foi eficiente em reduzir o grau de excreção sebácea de parkinsonianos «de novo», tornando-a significativamente menor em relação àqueles sob tratamento crônico. Não há diferença entre o grau de excreção sebácea de parkinsonianos «de novo» sem tratamento e parkinsonianos sob associação de drogas cronicamente. A possibilidade de ser a disfunção dopaminérgica hipotalâmica a origem do aumento da excreção sebácea em parkinsonianos é discutida, além de serem comparados os resultados apresentados aos registrados na literatura. Effects of L-dopa and biperiden on the sebum secretion in Parkinson's disease.SUMMARY -Sebum secretion was measured on the forehead of 47 patients with idiopathic Parkinson's disease before and after treatment with anticholinergic (biperiden), levodopa + AAID and bromocriptine, by the osmic acid technique. Another 100 patients under biperiden, levodopa 4-AAID or association of both, for at least one year, were also evaluated. The male parkinsonian «de novo» patients have shown greater sebum secretion than female patients. It was also concluded that biperiden failed to reduce sebum secretion rate. On the other hand, it was found that L-dopa + AAID reduces the sebum secretion (CL = casual level and SER = sebum excretion rate) on both male and female patients. Bromocriptine (l0mg/day) was the second dopaminergic therapy employed in the present work. Similarly to L-dopa, this dopaminergic agonist wa...

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<i>L</i>-Dopa and the Secretion of Sebum in Parkinsonian Patients

Cited by 9 publications

References 10 publications

Sebum secretion in idiopathic Parkinson's disease: effect of anticholinergic and dopaminergic drugs

Sebum secretion in idiopathic Parkinson's disease: effect of anticholinergic and dopaminergic drugs

Is seborrhea a sign of autonomic impairment in Parkinson's disease?

L-dopa, biperideno e excreção sebácea na doença de Parkinson

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