Is seborrhea a sign of autonomic impairment in Parkinson's disease?

Martignoni, E.; Godi, L.; Pacchetti, Claudio; Berardesca, Enzo; Vignoli, G. P.; Albani, G; Mancini, Francesca; Nappi, Giuseppe

doi:10.1007/bf01294730

Cited by 45 publications

(40 citation statements)

References 38 publications

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“…[26][27][28][29][30][31] The higher incidence of SD in patients with Parkinson's disease appears to be related to an increase in male sex hormone secretion and the effects of these hormones on the sebaceous glands rather than on autonomic dysfunction (dysautonomia), as was previously believed. 32 A higher prevalence of SD has also been found in cases of neuroleptic-induced Parkinsonism, in craniosynostosis, in familial amyloidotic polyneuropathy, in traumatic brain injury, traumatic spinal cord injury, cerebrovascular accidents (CVA), epilepsy and in facial nerve paralysis. 25,[33][34][35][36][37][38] SD has also been described as occurring exclusively on the side affected by paralysis in patients with CVA, following decompression for Chiari type-I malformation or in an area affected by syringomyelia.…”

Section: Introduction History and Epidemiologymentioning

confidence: 99%

Dermatite seborreica

Sampaio

Mameri²,

Vargas

et al. 2011

An. Bras. Dermatol.

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Seborrheic dermatitis is a chronic relapsing erythematous scaly skin disease, the prevalence of which is around 1 to 3% of the general population in the United States. It has two incidence peaks, the first in the first three months of life and the second beginning at puberty and reaching its apex at 40 to 60 years of age. The prevalence of seborrheic dermatitis is higher in HIV-positive individuals and the condition tends to be more intense and refractory to treatment in these patients. Neurological disorders and other chronic diseases are also associated with the onset of seborrheic dermatitis. The currently accepted theory on the pathogenesis of this disease advocates that yeast of Malassezia spp., present on the skin surface of susceptible individuals, leads to a non-immunogenic irritation due to the production of unsaturated fatty acids deposited on the skin surface. This article provides a review of the literature on seborrheic dermatitis, focusing on immunogenetics, the clinical forms of the disease and its treatment. . Keywords: Dermatitis; Dermatitis, seborrheic; Eczema Resumo: A dermatite seborreica é uma doença eritêmato-escamativa de caráter crônico-recidivante que acomete entre 1 e 3% da população geral dos Estados Unidos. Possui dois picos de incidência -o primeiro, durante os três primeiros meses de vida, e o segundo, a partir da puberdade, atingindo seu ápice entre os 40 e 60 anos de idade. Os indivíduos HIV positivos têm maior prevalência da doença, que apresenta maior intensidade e tendência à refratariedade ao tratamento. Doenças neurológicas e outras doenças crônicas também estão associadas ao desenvolvimento da dermatite seborreica. Como mecanismo fisiopatogênico, reconhece-se que o fungo Malassezia sp., presente na pele de indivíduos suscetíveis, leve a uma irritação não-imunogênica a partir da produção de metabólitos à base de áci-dos graxos insaturados deixados na superfície cutânea. Este artigo faz uma revisão da literatura sobre dermatite seborreica, com ênfase nos aspectos imunogenéticos, formas clínicas e tratamento.

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Section: Introduction History and Epidemiologymentioning

confidence: 99%

Dermatite seborreica

Sampaio

Mameri²,

Vargas

et al. 2011

An. Bras. Dermatol.

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“…Androgens exert a major boosting effect on sebocyte proliferation and sebum secretion [20,82,83]. The levels of 5·-reductase type 1 are significantly higher in sebaceous glands than in other skin structures [84].…”

Section: Hormonal Regulationmentioning

confidence: 99%

EEMCO Guidance for the in vivo Assessment of Skin Greasiness

Pierard

Piérard-Franchimont

Marks

et al. 2000

Skin Pharmacol Physiol

139

119

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Sebaceous gland activity has four distinct components which are sebum production (a secretion rate function), storage (a volume function), surface output (a delivery rate function) and stratum corneum permeation (an influx rate function). The oily appearance of skin results from an excess of sebum excretion and spreading over the body surface and its interaction with the skin surface. A multi-pronged approach is often useful to assess skin greasiness with precision. The clinical evaluation of skin greasiness and its shiny appearance should be further complemented by quantifying the large pores, follicular plugs and comedones. The sebum amount present at the skin surface can be measured non-invasively using one of several methods based on solvent extraction, cigarette paper pads, photometric assessment, bentonite clay and lipid-sensitive tapes. Quantitative parameters include the sebum casual level, the sebum excretion rate, the sebum replacement time, the instant sebum delivery, the follicular excretion rate, the density in sebum-enriched reservoirs and the sustainable rate of sebum excretion. A series of environmental and biological features influence the data. Hence rigorous methodological designs are mandatory to support claims. As a rule, accuracy of the methods is adversely affected by skin temperature, degree of hydration and surface roughness. An additional confounding factor is the inherent difficulty of collecting the surface lipids without a contribution from the follicular reservoir. A better understanding of factors that alter the sebum amount at the skin surface may well assist in the development of sebosuppressive agents to help the reduction of the skin greasiness and improve acne.

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“…This method measures the reduced opacity of a plastic foil compared to a control value in gg/cm 2. The method has already been described in detail elsewhere (Martignoni et at., 1997). The hydration of the Stratum corneum (corneometry) was determined using the corneometer CM 820 (Courage + Khazaka, (].ologne, Germany) as an absolute value.…”

Section: Methodsmentioning

confidence: 99%

“…The phenomenon of increased sebum production was first described in the 20's (Cohn, 1920) and appears to be particularly severe in postencephalitic Parkinson's disease. However, a number of investigations have also shown seborrhoea in idiopathic Parkinson's syndrome (PS) (Baas, 1984;Burton et al, 1973;Kohn et al, 1973;Martignoni et al, 1997;Pochi et al, 1962). More extensive investigations into other skin functions in Morbus 206 M. Fischer et al…”

Section: Introductionmentioning

confidence: 95%

Skin function and skin disorders in Parkinson’s disease

et al. 2001

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Cutaneous symptoms (seborrhoea and hyperhidrosis) in Parkinson's disease were investigated. In 70 treated patients with Parkinson's disease and 22 control subjects, non-invasive bioengineering methods (sebumetry, corneometry, pH) were carried out on the forehead, sternum and forearm. In addition, concomitant dermatoses and medication were recorded. 18.6% of the patients had seborrhoea on the forehead (>220 microg/cm2), 51.4% showed normal sebum values (100-220 microg/cm2) and 30% a sebostasis (<100 microg/cm2). Males has significantly higher sebum values than females. No relationship between the seborrhoea and the therapy for Morbus Parkinson was found. Patients with hyperhidrosis (n = 36) had significantly lower pH values (p < 0.05) on the forehead than those without hyperhidrosis. 22 patients (31.9%) reported a cold/hot flush and a further 13 (18.8%) had clinical rosacea. Seborrhoea is rare in treated Parkinsonian patients but hyperhidrosis is frequently found. Furthermore, a particular lack of vasostability (flush) appears to be an autonomic dysregulation in the skin related to Morbus Parkinson, which has not been studied to any extent to date.

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Is seborrhea a sign of autonomic impairment in Parkinson's disease?

Cited by 45 publications

References 38 publications

Dermatite seborreica

Dermatite seborreica

EEMCO Guidance for the in vivo Assessment of Skin Greasiness

Skin function and skin disorders in Parkinson’s disease

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