<b>Symphonin: A new prenylated pyranoxanthone With antimicrobial activity from the seeds of <i>Symphonia globulifera</i> (guttiferae)</b>

Abstract

A new prenylated pyranoxanthone, symphonin (1), 2-(3,3-dimethylallyl)-1,5dihydroxy-6,7-dimethoxy-2",2"-dimethylpyrano (5",6":3,4) xanthone, the known compounds guttiferone A, oleanolic acid and sitosterol were isolated from the methanol extract of the seeds of Symphonia globulifera (Guttiferae). The structural elucidation of the new compound was based mainly on spectroscopic analyses. The new xanthone showed antimicrobial activity against Staphylococcus aureus, Streptococcus feacalis, Klebsiella pneumonia and Escherichia coli.

Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f.

“…1). In addition to (1), six known compounds were isolated and identified as symphonin (2), globuliferin (3), guttiferone A (4), oleanolic acid, sistosterol and methyl citrate (Lenta et al, 2004;Ngouela et al, 2005;Gustafson et al, 1992;Mahato and Kundu, 1994;Ando et al, 1972).…”

“…Polyprenylated xanthones and benzophenones isolated from this plant were found to have various biological activities (Nkengfack et al, 2002;Peres and Nagem, 1997;Gustafson et al, 1992), but very few studies have been carried out on their anti-plasmodial activity. Previously, we reported the isolation of the xanthones symphonin and globuliferin from the seeds of S. globulifera (Lenta et al, 2004;Ngouela et al, 2005). In our continuing interest in searching for new biologically active metabolites, we investigated the seed shells of this plant.…”

Comprehensive multivariate correlations between climatic effect, metabolite-profile, antioxidant capacity and antibacterial activity of Brazilian red propolis metabolites during seasonal study

“…Lenta et al . 64 demonstrated antimicrobial activity of Simphonin, a prenylated xanthone. Almeida et al .…”

Leishmanicidal and Cholinesterase Inhibiting Activities of Phenolic Compounds from Allanblackia monticola and Symphonia globulifera

“…Clusiaceae are well known to biosynthesize bioactive benzophenones and xanthones [2][3][4][5][6][7][8]. Xanthones are known to show a wide range of biological activity such as antibacterial, antidiabetic, antiplasmodial, human cancer cell line growth inhibition, antihypertensive and vasorelaxing, cardiovascular protection, inhibition of HIV-1 reverse transcriptase and HIV-1 replication [9][10][11][12][13][14][15][16].…”