LSPR-based nanobiosensors

Sepúlveda, Borja; Angelomé, Paula C.; Lechuga, Laura M.; Liz‐Marzán, Luis M.

doi:10.1016/j.nantod.2009.04.001

Cited by 895 publications

(631 citation statements)

References 88 publications

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“…[28] In fact, the oscillation frequency of electrons surrounding nanoparticles can be affected through changing the solvent, which will change the dielectric constant; however, the most important factor in determining the change of plasmon resonance absorbance is the capping material, which will have a local effect on the surface of the nanoparticle. [29] The interaction between DNA and negatively charged metallic nanoparticles has been studied for many years.…”

Section: Interaction Of Aptameth and Gnpsmentioning

confidence: 99%

Unmodified gold nanoparticles as a colorimetric probe for visual methamphetamine detection

Yarbakht

Nikkhah

2015

Journal of Experimental Nanoscience

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In recent years, in addition to the classic drugs, addiction to a series of new drug classes known as club drugs has increased significantly. Fast and lowcost bioassay for the detection of amphetamine-based drugs can be an effective strategy towards reducing their abuse. In this study, we designed a sensitive bioassay strategy using gold nanoparticles (GNPs) and the aptamers that possess high affinity toward methamphetamine (MA). It is suggested that the aptamer adopts different tertiary structures in the presence and/or absence of its specific target and GNPs can effectively differentiate between these two states by their characteristic surface plasmon resonance-based colour change. Visual detection of MA and 3,4-methylenedioxy-N-methylamphetamine (MDMA) in the low micromolar range is possible within minutes with the use of this method.

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Section: Interaction Of Aptameth and Gnpsmentioning

confidence: 99%

Unmodified gold nanoparticles as a colorimetric probe for visual methamphetamine detection

Yarbakht

Nikkhah

2015

Journal of Experimental Nanoscience

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“…Localized surface plasmon resonance (LSPR)-based nanobiosensors are emerged as ultrahigh-sensitivity sensing devices relying on the change of surrounding refractive index or the interaction with other metallic nanostructures [147,148]. This is a powerful tool that enables a very low concentration detection or even single molecular detection of biological samples such as proteins or DNAs.…”

Section: Optics and Photonicsmentioning

confidence: 99%

Review on Micro- and Nanolithography Techniques and their Applications

2012

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Abstract. This article reviews major micro-and nanolithography techniques and their applications from commercial micro devices to emerging applications in nanoscale science and engineering. Micro-and nanolithography has been the key technology in manufacturing of integrated circuits and microchips in the semiconductor industry. Such a technology is also sparking revolutionizing advancements in nanotechnology. The lithography techniques including photolithography, electron beam lithography, focused ion beam lithography, soft lithography, nanoimprint lithography and scanning probe lithography are discussed. Furthermore, their applications are summarized into four major areas: electronics and microsystems, medical and biotech, optics and photonics, and environment and energy harvesting.

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“…[1][2][3][4][5][6] The absorption maximum and intensity of the LSPR bands depend on the size and shape of the metal NPs, the distance between them, and the effective refractive index of the local environment. [1][2][3][4][5][6][7][8][9] Among these properties, the dependence of LSPR bands on the change in the local refractive index around NPs is associated with the use of NPs in label-free sensing applications, where the LSPR sensing is based on the change in the local refractive index around NPs, caused by analyte binding. This LSPR wavelength shift, which is based on the change in the refractive index, can be examined by using UV-vis transmission or reflection spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

Use of thermally annealed multilayer gold nanoparticle films in combination analysis of localized surface plasmon resonance sensing and MALDI mass spectrometry

Inuta

Arakawa

Kawasaki

2011

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A self-assembled film of gold nanoparticles (AuNPs) with a raspberry-like morphology was prepared on a glass plate by the layer-by-layer thermal annealing of multilayer films of AuNPs. It was possible to control the morphology of the obtained films of AuNPs by changing the annealing temperature, duration of annealing, and number of layers. On investigating the plasmonic properties of these films, we found that AuNP films with a raspberry-like morphology yielded the highest refractive index unit, which is a critical parameter in localized surface plasmon resonance (LSPR) sensing, as compared to other types of AuNP films. Self-assembled AuNP films with a raspberry-like morphology were subsequently functionalized with 11-mercaptoundecanoic acid (MUA) to enable the binding of lysozyme to the MUA-modified Au surface. The superior limit of detection for the LSPR sensing of lysozyme in a buffer solution was found to be in the picomolar range ($10 À12 M). The high sensitivity observed in the region was attributed to the raspberry-like morphology, where the AuNPs were packed closely together, and the electromagnetic field confinement was most intense (i.e., at hot spots). The MUA-modified, self-assembled AuNP films with a raspberry-like morphology were finally used in the combination analysis of LSPR sensing and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) for the selective detection and identification of lysozyme in human serum.

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LSPR-based nanobiosensors

Cited by 895 publications

References 88 publications

Unmodified gold nanoparticles as a colorimetric probe for visual methamphetamine detection

Unmodified gold nanoparticles as a colorimetric probe for visual methamphetamine detection

Review on Micro- and Nanolithography Techniques and their Applications

Use of thermally annealed multilayer gold nanoparticle films in combination analysis of localized surface plasmon resonance sensing and MALDI mass spectrometry

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