Loxoscelism of the Eyelids

Brown recluse spider bite to the leg

“…Our review of the literature identified only a few reported cases of loxoscelism involving the foot. 3,15,7 Although these cases described lesions consistent with bites caused by the bite of a Brown recluse spider, none of them provided conclusive evidence that the lesions were indeed caused by L. reclusus. We noted remarkable similarities among documented cases and our own in terms of the progression of the lesions.…”

“…Cutaneous manifestations are not as severe. 3,14,7 Associated symptoms tend to be mild and may include fever, malaise, headache, and pruritus. 7 Systemic loxoscelism, although much more rare, is far more serious and usually develops 2-3 days after the bite.…”

Reconstructive considerations following a necrotic spider bite on the face: A case report

“…Complete healing in these two cases happened in 2 and 3 weeks respectively [12], [13]. Time to complete healing in the remaining four cases exclusively let to heal by secondary intention, was 2 months (one patient; healed with no scarring [4]) and 6 months respectively (three patients; healed with scarring [10], [14]).…”

Periorbital edema

“…To understand better the more common Spider bite [20,21,63] Dermatographism [59] Hepatitis B [10] Tumor necrosis factor receptor-associated periodic syndrome [60,64] Chagas disease [18] Cutis laxa [65] Trichinellosis [14] Blepharochalasis [57,66,67] Epstein-Barr virus [8,9,68] Eyelid metastasis [69] Ophthalmofilariasis [15] Rosacea [51,52] Pott's puffy tumor [28] Sickle cell orbital infarction [70] Necrotising fasciitis [23] Langerhans cell histiocytosis [71] Ophthalmomyiasis [16] Tolosa-Hunt syndrome [72,73] Blister beetle dermatitis [22] Dermatomyositis [36,39,40,74] Rocky Mountain spotted fever [13] Juvenile dermatomyositis [37,38,75] Amebiasis [19] Sarcoid [76] Leukemia [77] Indeed, by definition, these cases were reportable.…”

“…Some notable cases of severe periorbital edema have been reported from the brown recluse spider [20,21] and Blister beetle [22]. Patients may be unaware of getting bitten, so focus should be placed on ruling out an entrance wound.…”