Lowest Effective Single Dose of Diclofenac for Antipyretic and Analgesic Effects in Acute Febrile Sore Throat

Géhanno, P; Dreiser, R.-L.; Ionescu, Elisabeta; Gold, Morris S.; Liu, Jiun-Min

doi:10.2165/00044011-200323040-00006

Cited by 27 publications

(16 citation statements)

References 7 publications

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“…No significant adverse events were noted. In other randomized, doubleblind, and placebo-controlled studies, significantly greater pain relief with use of acetaminophen compared with placebo has been documented among both children and adults, although improvement in symptoms was not always equivalent to that obtained through use of ibuprofen [106][107][108][109].…”

Section: Evidence Summarymentioning

confidence: 93%

Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America

Shulman¹,

Bisno

Clegg³

et al. 2012

Clinical Infectious Diseases

801

808

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The guideline is intended for use by healthcare providers who care for adult and pediatric patients with group A streptococcal pharyngitis. The guideline updates the 2002 Infectious Diseases Society of America guideline and discusses diagnosis and management, and recommendations are provided regarding antibiotic choices and dosing. Penicillin or amoxicillin remain the treatments of choice, and recommendations are made for the penicillin-allergic patient, which now include clindamycin.

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Section: Evidence Summarymentioning

confidence: 93%

Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America

Shulman¹,

Bisno

Clegg³

et al. 2012

Clinical Infectious Diseases

801

808

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“…Paracetamol is known to be effective and superior to placebo at reducing fever, headache and throat pain for up to 6 h (level 1 evidence) . Non‐steroidal anti‐inflammatory drugs (NSAIDS), namely diclofenac and ibuprofen, are also highly effective when compared to placebo (level 1 evidence). NSAIDS should be used with caution in the presence of dehydration due to nephrotoxic effects, and rehydration therapy should be commenced in conjunction.…”

Section: Resultsmentioning

confidence: 99%

Controversies in the management of acute tonsillitis: an evidence‐based review

Bird

Biggs

King

2014

Clinical Otolaryngology

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Management of acute tonsillitis within a secondary care setting largely consists of anecdotal or relatively low-quality evidence. Thus, much evidence from management comes from expert opinion or practice within a primary care setting. Management across the UK can also vary greatly. An evidence-based review of best practice has been presented here, but further evidence will be required in the future examining the significance of corticosteroids and antibiotic administration in this patient cohort specifically, ensuring practice is evidence based and clinically relevant.

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“…Gehanno [84] To compare the anti-pyretic and analgesic effects of a single oral dose of diclofenac potassium 6.25, 12.5 or 25 mg with paracetamol 1000 mg and placebo in patients with fever resulting from acute febrile sore throat…”

Section: Rct 2a+mentioning

confidence: 99%

Guideline for the management of acute sore throat

Pelucchi

Grigoryan

Galeone

et al. 2012

Clinical Microbiology and Infection

251

230

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Clin Microbiol Infect 2012; 18 (Suppl. 1): 1–27 Abstract The European Society for Clinical Microbiology and Infectious Diseases established the Sore Throat Guideline Group to write an updated guideline to diagnose and treat patients with acute sore throat. In diagnosis, Centor clinical scoring system or rapid antigen test can be helpful in targeting antibiotic use. The Centor scoring system can help to identify those patients who have higher likelihood of group A streptococcal infection. In patients with high likelihood of streptococcal infections (e.g. 3–4 Centor criteria) physicians can consider the use of rapid antigen test (RAT). If RAT is performed, throat culture is not necessary after a negative RAT for the diagnosis of group A streptococci. To treat sore throat, either ibuprofen or paracetamol are recommended for relief of acute sore throat symptoms. Zinc gluconate is not recommended to be used in sore throat. There is inconsistent evidence of herbal treatments and acupuncture as treatments for sore throat. Antibiotics should not be used in patients with less severe presentation of sore throat, e.g. 0–2 Centor criteria to relieve symptoms. Modest benefits of antibiotics, which have been observed in patients with 3–4 Centor criteria, have to be weighed against side effects, the effect of antibiotics on microbiota, increased antibacterial resistance, medicalisation and costs. The prevention of suppurative complications is not a specific indication for antibiotic therapy in sore throat. If antibiotics are indicated, penicillin V, twice or three times daily for 10 days is recommended. At the present, there is no evidence enough that indicates shorter treatment length.

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Lowest Effective Single Dose of Diclofenac for Antipyretic and Analgesic Effects in Acute Febrile Sore Throat

Cited by 27 publications

References 7 publications

Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America

Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America

Controversies in the management of acute tonsillitis: an evidence‐based review

Guideline for the management of acute sore throat

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