Lowered cholesterol catabolism in guinea pigs with chronic ascorbic acid deficiency

Relation of Serum Ascorbic Acid to Serum Lipids and Lipoproteins in US Adults

“…In experimental animals, ascorbic acid affects the catabolism of cholesterol to bile acids [1][2][3][4][5][6][7]. Administration of ascorbic acid attenuates the expected rise in serum cholesterol in cholesterol-fed rabbits [8 -12] and exerts a hypolipidemic effect in guinea pigs [6,[13][14][15].…”

Effect of Ascorbic Acid Administration on B and E Apoproteins in Rats Fed a Cholesterol Enriched Diet

“…So far many researches have pointed out the effect of ascorbic acid on cholesterol metabolism either in humans (Ginter, Bobek, Kubek, Vozar and Urbanova 1982) or in animals that are not able to produce it {Ginter, Cerven, Nemec and Mikus 1971). Clinical studies described a positive correlation between plasma ascorbate and high density lipoprotein (HDL) cholesterol (Jacques, Hartz, McGandy Jacob and Russel 1987) and a negative correlation between plasma ascorbate and plasma cholesterol (Burr, Bates, Milbank and Yarnell 1982).…”

Effects of dietary polychlorinated biphenyls on cholesterol catabolism in rats

“…In the guinea-pig receiving an inadequate dose of L-ascorbic acid there is an impairment in the conversion of cholesterol to bile acids resulting in hypercholesterolaemia (Ginter et a!. 1971 ;Holloway & Rivers, 1981).…”

“…They postulated that the decrease of chenodeoxycholic acid caused hypercholesterolaemia in aged rats, based on biliary bile acid composition. Other conditions, such as ascorbic acid deficiency (Ginter et al 1971 ;Holloway & Rivers, 1981) or hypothyroidism (Takeuchi et al 1975;Abrams & Grundy, 198 I ) associated with changes in cholesterol catabolism, may be a more important factor * Present address: Department of Food Science, Faculty of Agriculture, Gifu University, Gifu 501-1 1, Japan. * Composition as described by Harper (1959).…”