Relation of Serum Ascorbic Acid to Serum Lipids and Lipoproteins in US Adults

Simon, Joel A.; Hudes, Esther S.

doi:10.1080/07315724.1998.10718755

Cited by 25 publications

(10 citation statements)

References 33 publications

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“…Marc and Kothari and Sharma have further observed that vitamin C administration causes significant reduction in LDL and increase in HDL [87] and there by provides protection against CAD [87,90]. Similar observations have been given by others also [91][92][93][94][95][96]. Chronic AA deficiency in man can lead to impaired cholesterol metabolism resulting in atheromatous changes in the vascular system [87].…”

Section: Vitamin C and Atherosclerosissupporting

confidence: 67%

Vitamin C in Disease Prevention and Cure: An Overview

et al. 2013

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The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections. However the significance and beneficial effect of vitamin C in respect to human disease such as cancer, atherosclerosis, diabetes, neurodegenerative disease and metal toxicity however remains equivocal. Thus further continuous uninterrupted efforts may open new vistas to understand its significance in disease management.

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Section: Vitamin C and Atherosclerosissupporting

confidence: 67%

Vitamin C in Disease Prevention and Cure: An Overview

et al. 2013

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“…Ascorbic acid protects oxidation of lipids in low density lipoprotein by its ability to regenerate α‐tocopherol from tocopheroxyl radical, the latter being produced by interaction of α‐tocopherol with the lipid derived radical species (Packer et al 1979). Earlier studies indicate that the hypolipidaemic effect of ascorbic acid may not be entirely related to its antioxidant action (Simon & Hudes 1998). In animal studies ascorbic acid has been shown to increase the metabolism of cholesterol to bile acids in the liver (Ginter 1975).…”

Section: Discussionmentioning

confidence: 99%

Attenuation of Abnormalities in the Lipid Metabolism during Experimental Myocardial Infarction Induced by Isoproterenol in Rats: Beneficial Effect of Ferulic Acid and Ascorbic Acid

Yogeeta

Hanumantra

Arunachalam

et al. 2006

Basic Clin Pharma Tox

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The present study aims at evaluating the effect of the combination of ferulic acid and ascorbic acid on isoproterenol-induced abnormalities in lipid metabolism. The rats were divided into eight groups: Control, isoproterenol, ferulic acid alone, ascorbic acid alone, ferulic acidπascorbic acid, ferulic acidπisoproterenol, ascorbic acidπisoproterenol and ferulic acidπascorbic acidπisoproterenol. Ferulic acid (20 mg/kg b.w.t.) and ascorbic acid (80 mg/kg b.w.t.) both alone and in combination was administered orally for 6 days and on the fifth and the sixth day, isoproterenol (150 mg/kg b.w.t.) was injected intraperitoneally to induce myocardial injury to rats. Induction of rats with isoproterenol resulted in a significant increase in the levels of triglycerides, total cholesterol, free fatty acids, free and ester cholesterol in both serum and cardiac tissue. A rise in the levels of phospholipids, lipid peroxides, low density lipoprotein and very low density lipoprotein-cholesterol was also observed in the serum of isoproterenol-intoxicated rats. Further, a decrease in the level of high density lipoprotein in serum and in the phospholipid levels, in the heart of isoproterenol-intoxicated rats was observed, which was paralleled by abnormal activities of lipid metabolizing enzymes: total lipase, cholesterol ester synthase, lipoprotein lipase and lecithin: cholesterol acyl transferase. Pre-cotreatment with the combination of ferulic acid and ascorbic acid significantly attenuated these alterations and restored the levels to near normal when compared to individual treatment groups. Histopathological observations were also in correlation with the biochemical parameters. These findings indicate the synergistic protective effect of ferulic acid and ascorbic acid on isoproterenol-induced abnormalities in lipid metabolism.

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“…Hypolipidaemic effects of vitamin C which may not be related to its antioxidant action have been reported (Simon & Hudes, 1998). In animal studies vitamin C has been shown to increase the metabolism of cholesterol to bile acids in the liver (Ginter, 1975), and in guinea-pigs sodium ascorbate intakes of up to 5mg/d have been shown to significantly (P = 0·025) reduce plasma cholesterol and increase bile acid formation (Hornig & Weiser, 1976).…”

Section: Vitamin C Ldl Oxidation and Lipoprotein Metabolismmentioning

confidence: 99%

“…Most studies, however, have shown a negative association between triacylglycerols and serum vitamin C and a positive association between HDL and serum vitamin C levels. The association between vitamin C and lipids has been discussed in several papers (Ness et al 1996;Simon & Hudes, 1998), including a review by Simon (1992), and it has been suggested that associations between vitamin C and serum lipids, including HDL-cholesterol, seem to be more prominent in hyperlipidaemic subjects. Various mechanisms have been proposed to explain the association between vitamin C and lipoprotein metabolism.…”

Section: Vitamin C Ldl Oxidation and Lipoprotein Metabolismmentioning

confidence: 99%

Antioxidants and lipoprotein metabolism

Chopra

Thurnham

1999

Proc. Nutr. Soc.

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fax +44 (0) 1265 324965, email m.chopra@ulst.ac.uk Lipoprotein metabolism plays a significant role in the pathogenesis of atherosclerosis and risk of vascular disease. Elevated levels of LDL and low levels of HDL are linked to the risk of cardiovascular disease. It is now widely accepted that oxidative modification of LDL affects the metabolism of lipoproteins, leading to their increased accumulation in arterial intima. The present paper will examine some of the accumulating evidence from studies showing relationships between dietary intake of antioxidant nutrients, i.e. vitamins E and C, the carotenoids and the flavonoids, and their influence on lipoprotein metabolism. In particular, the present paper will review the available literature on the affect of antioxidant supplementation on lipoprotein oxidation, and hence metabolism of LDL in human subjects.

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Relation of Serum Ascorbic Acid to Serum Lipids and Lipoproteins in US Adults

Abstract: If the observed associations are linked causally, they would suggest that ascorbic acid is a factor in cholesterol homeostasis among women and may be particularly important for women at increased risk for coronary heart disease.

Cited by 25 publications

References 33 publications

Vitamin C in Disease Prevention and Cure: An Overview

Vitamin C in Disease Prevention and Cure: An Overview

Attenuation of Abnormalities in the Lipid Metabolism during Experimental Myocardial Infarction Induced by Isoproterenol in Rats: Beneficial Effect of Ferulic Acid and Ascorbic Acid

Antioxidants and lipoprotein metabolism

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