Vitamin C in Disease Prevention and Cure: An Overview

Chambial, Shailja; Dwivedi, Shailendra; Shukla, Kamla Kant; John, P. J.; Sharma, Praveen

doi:10.1007/s12291-013-0375-3

Cited by 383 publications

(256 citation statements)

References 190 publications

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“…[9] It also plays a role in the formation of folic acid. [8] These effects help to explain why many patients including ours present with anemia. There is emerging evidence that ascorbic acid may also be involved in other reactions such as histone demethylation, resultantly helping to regulate genes expression.…”

Section: Discussionmentioning

confidence: 70%

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Vitamin C or not to see: A diagnostic dilemma

Zemore

Warner

2015

CRIM

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Scurvy is a severe deficiency of vitamin C, or ascorbic acid. Despite it's perceived rarity in developed countries, certain populations are at higher risk of developing scurvy, and a delay in diagnosis can lead to significant morbidity and possibly death. In this case, a 46-year-old female was admitted to the hospital with subtle mood changes, memory loss, and generalized failure to thrive. Physical exam revealed a petechial rash. Evaluation and workup by multiple physicians revealed no source for her condition, which continued to deteriorate. Finally, because of the patient's rash, a nutritional history was taken which was highly concerning for scurvy. An ascorbic acid level was ordered and returned at 0 mg/dl (reference range 0.2-2 mg/dl), confirming the clinical diagnosis of scurvy. Ascorbic acid repletion reversed her symptoms and she was discharged home uneventfully. Ascorbic acid is vital for the integrity of skin and soft tissues. Due to its high prevalence in the diets of most developed countries, scurvy has become a rare diagnosis that many providers do not recognize. Despite its rarity, certain populations are still at risk and providers should remain cognizant of the diagnosis, especially when classic manifestations such as a petechial rash or bleeding gums are seen.

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Section: Discussionmentioning

confidence: 70%

“…It is involved in the formation of several neurotransmitters, amino acids and catecholamines. [8] It increases the absorption of iron up to 10 times by reducing ferric iron to its absorbable ferrous form. [9] It also plays a role in the formation of folic acid.…”

Section: Discussionmentioning

confidence: 99%

Vitamin C or not to see: A diagnostic dilemma

Zemore

Warner

2015

CRIM

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“…There are also reports indicating that AA can enhance the effectiveness of chemotherapeutic agents that can reduce the cytotoxicity of anticancer drugs, and also may prevent free radicals and neutralize some carcinogens [14,46,47]. The identification of the variety of responses to cancer therapy requires knowledge of variables, including concomitant medications, which may alter the metabolism and pharmacokinetics of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Most patients in chemotherapy make supplementation with vitamins, especially, vitamin C, due to its high antioxidant capacity, which may cause antagonistic effects to antineoplastic and neutralize some carcinogens [14,15]. Antioxidants such as vitamin C compose the human diet [16], which not only sequester free radicals, but also regulate DNA repair enzymes and post-transcriptional factors [17].…”

Section: Introductionmentioning

confidence: 99%

Ascorbic acid modulates doxorubicin and cyclophosphamide-induced cytogenetic damages in Sarcoma 180 cells

Alencar¹,

Islam²,

Rocha³

et al. 2016

Int Arch Med

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Cancer is a public health global problem. Cyclophosphamide (CPA) and Doxorubicin (DOX) are used in chemotherapy, especially by generating reactive oxygen species. The clinical use of ascorbic acid during chemotherapy also raises several controversies due to its antagonistic effects on antineoplastic agent. In this sense, this study aims to evaluate the effects of ascorbic acid (2 µg/mL) on the modulation of cytogenetic damage induced by CPA (20 µg/mL) and DOX (2 µg/ mL), as well as their interaction (AC protocol) on Sarcoma 180 tumor cells. Cytogenetic damage classified as apoptosis, necrosis, micronuclei, buds and nucleoplasmic bridges were linked to the CytokinesisBlock Micronucleus Assay application. CPA and DOX induce significant (p<0.05) increases in apoptosis, necrosis and micronuclei in the cell types tested. The damage on Sarcoma 180 cells was modulated by ascorbic acid with percentage modulation in more than 70% of CPA relative to apoptosis and micronuclei, and 32% to necrosis. The damage of DOX has been modulated by 70% to apoptosis, 40% to necrosis, rather than micronuclei, whereas, in AC protocol, modulations were observed by 52% to apoptosis and 32% and 40% to necrosis and micronuclei, respectively. There was no significance in relation to the nuclear buds and nucleoplasmic bridges. In addition, ascorbic acid did not show any effect. These results are other studies, which indicate hazards to chemotherapy effectiveness due to the antioxidant effects

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“…Vitamin C is found in citrus fruits, peppers, strawberries, tomatoes, broccoli, brussels sprouts and other leafy vegetables. AA is a water-soluble vitamin, and because of its hydrophilic nature, it has more effective scavenging properties at the plasma level than in the lipid bilayer [119].…”

Section: Vitamin Cmentioning

confidence: 99%

Physiological and Pathological Roles of Free Radicals in Male Reproduction

Tvrdá¹,

Massányi²,

Lukáč³

2018

Spermatozoa - Facts and Perspectives

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Oxidative stress (OS) is a condition caused by an imbalance between reactive oxygen species (ROS) overgeneration and decreased antioxidant defense mechanisms in the cell. OS has become a prominent factor in male reproductive dysfunction as ROS cause damage to sperm DNA, lipids and proteins, alterations to critical sperm structures and signaling pathways, leading to a decreased sperm activity and fertilizing capacity. At the same time, small amounts of ROS play vital roles in events leading to sperm maturation and acquisition of functional activity, which is why a proper oxidative balance is of paramount importance for a proper male fertility. Understanding the physiological and pathological roles of ROS in male reproduction has become an essential pillar of modern andrology; however, numerous questions related to the controversial behavior of ROS in male reproductive cells and tissues still remain unanswered. This chapter aims to summarize current evidence available on the relationships between free radicals, antioxidants and male reproduction and to trigger more scientific interest, particularly with respect to the design of efficient strategies to diagnose or treat male sub-or infertility associated with OS.

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Vitamin C in Disease Prevention and Cure: An Overview

Cited by 383 publications

References 190 publications

Vitamin C or not to see: A diagnostic dilemma

Vitamin C or not to see: A diagnostic dilemma

Ascorbic acid modulates doxorubicin and cyclophosphamide-induced cytogenetic damages in Sarcoma 180 cells

Physiological and Pathological Roles of Free Radicals in Male Reproduction

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