Lower prenatal vitamin D status and postpartum depressive symptomatology in African American women: Preliminary evidence for moderation by inflammatory cytokines

Accortt, Eynav Elgavish; Schetter, Christine Dunkel; Peters, Rosalind M.; Cassidy‐Bushrow, Andrea E.

doi:10.1007/s00737-015-0585-1

Cited by 60 publications

(90 citation statements)

References 80 publications

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“…Leptin may represent a pathway through which obese individuals may develop depression, or a common mechanism leading to both depression and obesity (Morris et al 2012). The correlation between inflammation and postpartum depressive symptom had been investigated (Accortt et al 2015). In our study, a slight correlation between levels of serum leptin and Hs-CRP (r = 0.182, P = 0.012) had been found.…”

Section: Discussionmentioning

confidence: 71%

Serum leptin level measured 48 h after delivery is associated with development of postpartum depressive symptoms: a 3-month follow-up study

Chen

Gao

Zhang

et al. 2016

Arch Womens Ment Health

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The aim of this study was to assess the possible relationship between leptin status and postpartum depressive symptoms using serum levels of leptin collected 24-48 h after delivery in a cohort Chinese sample. Women delivering a full-term, singleton, and live-born infant in the period from August 2013 to March 2014 were enrolled immediately postpartum. A blood sample was obtained 24-48 h after childbirth to test serum levels of leptin. Participation consisted of a visit in an obstetric unit at 3 months after delivery. The Edinburgh Postnatal Depression Scale (EPDS), completed at 3 months postpartum, was used to classify each woman's depression symptom severity. Demographic, obstetric, behavioral risk, mental health, and psychosocial factors were considered. Multiple logistic regression analyses were used to identify risk factors most predictive of postpartum depressive symptoms. During the study period, 407 individuals were included and completed follow-up. At 3 months, according to EPDS score, 53 women (13.0 %) were considered as postpartum depressive symptoms. Serum leptin levels in women with PPD were significantly greater than those in women without depressive symptoms (36.5 [IQR, 25.5-50.4] vs. 14.5 [IQR, 9.4-22.4] ng/ml, P < 0.0001). Based on the ROC curve, the optimal cutoff value of serum leptin levels as an indicator for predicting of depressive symptoms was projected to be 24.3 ng/mL, which yielded a sensitivity of 88.7 % and a specificity of 73.4 %, with the area under the curve at 0.867 (95 % CI, 0.817-0.916). In multivariate analysis, there was an increased risk of depressive symptoms associated with leptin levels ≥24.3 ng/ml (OR 8.234; 95 % CI, 3.572-15.876; P < 0.0001) after adjusting for possible confounders. Elevated serum leptin levels at delivery could eventually serve as a biological marker for the prediction of depressive symptoms. These associations were independent of other possible variables.

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Section: Discussionmentioning

confidence: 71%

Serum leptin level measured 48 h after delivery is associated with development of postpartum depressive symptoms: a 3-month follow-up study

Chen

Gao

Zhang

et al. 2016

Arch Womens Ment Health

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“…Several studies have reported an inverse association between plasma 25OH-VD 3 concentrations and affectiverelated symptoms in women (Gaugris et al, 2005). In line with these observations, lower mood symptoms occurred more frequently in women with VD 3 deficiency/insufficiency, and VD 3 improved the mood state in such women (Kjaergaard et al, 2011;Accortt et al, 2016). The possible mechanism of VD 3 action might be explained by the stimulation of VDR identified in the different brain structures involved in mood control (Berridge, 2017).…”

Section: Discussionmentioning

confidence: 71%

Vitamin D3 attenuates anxiety-like behavior in long-term ovariectomized rats with unpredictable mild stress

Baranenko¹,

Fedotova²,

Tol³

2019

Biocell

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The impact of various vitamin D3 (VD3) doses (1.0, 2.5, or 5 mg/kg, s.c.) in mitigating the negative consequences of chronic unpredictable mild stress (CUMS) was investigated. Adult female rats with long-term estrogen deficiency were assessed using the sucrose preference test (SPT), the elevated plus-maze (EPM), the light/dark test (LDT), and the open-field test (OFT) to measure anhedonia-like and anxiety-like behavior. The corticosterone (CS) and adrenocorticotrophic hormone (ACTH) concentrations in blood serum and the brain-derived neurotrophic factor (BDNF) expression in the hippocampus of long-term ovariectomized (OVX) rats were measured by ELISA kits and/ or western blotting. Treatment with VD3 (5.0 mg/kg), similarly to fluoxetine (10.0 mg/kg), significantly reduced the anhedonia profile in the SPT and anxiety-like behavior in the EPM and LDT, and CS and ACTH levels in blood serum.It also elevated BDNF levels in the hippocampus of long-term OVX/CUMS compared to OVX/CUMS/solvent rats.Thus, these findings suggest that VD3 (5.0 mg/kg) administration might attenuate the anxiety-like profile in longterm OVX adult rats subjected to the CUMS. This might occur via activation of the BDNF signaling pathway in the hippocampus and via restoration of CS and ACTH levels in blood serum.

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“…In contrast, Nielson et al, [10] in a case-control study on 605 women with postpartum depression and 875 controls found that there was no significant relationship between vitamin D and postpartum depression, but a high serum level of vitamin D was associated with postpartum depression. Another study also confirmed an association between a higher level of inflammatory markers and low levels of prenatal vitamin D and postpartum depression [11]. Although Vaziri et al showed that consumption of 2000 IU of vitamin D could significantly reduce the depression score at 38–40 weeks of gestation and also after birth [12], there is still a paucity of information regarding vitamin D level among Iranian pregnant women and postpartum depression.…”

Section: Introductionmentioning

confidence: 87%

The Relationship Between Vitamin D and Postpartum Depression in Reproductive-Aged Iranian Women

et al. 2018

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Background The aim of this study was to evaluate the relationship between vitamin D and postpartum depression in reproductive-aged Iranian women. Methods and Results This study was conducted on 120 women (60 with postpartum depression and 60 without) in Izeh, Iran. A socio-demographic questionnaire and Beck Depression Scale were used for data collection. The ELISA method was used for measuring 25-OH vitamin D (ng). The participants were classified according to their vitamin D level as follows: 25-OH-D < 10ng/ml considered as severe deficiency, 10–20n g/ml as moderate insufficiency, 20–30 ng/ml as mild insufficiency and >30ng/ml as normal. Data were analyzed using the independent t-test or Mann-Whitney test, chi-square and logistic regression test. The mean level of vitamin D of women with postpartum depression was lower than that in normal women (16.89±7.05 vs. 21.28±7.13, p=0.001). More than 53% of women with postpartum depression had vitamin D <20 ng/ml compared to 31.7% of women with no depression (p=0.005). Moreover, 16.7% of women with postpartum depression had vitamin D < 10ng/ml compared to only 6.7% in the normal group (p = 0.005). Women with vitamin D less than 20ng/ml compared to vitamin D > 20ng/ml were 3.30 times more likely to have postpartum depression (OR: 3.3, CI: 1.32–8.24, p= 0.01). Discussion There is a significant relationship between a low level of vitamin D and postpartum depression among reproductive-aged Iranian women. Health policy makers should pay attention to the measuring vitamin D level as one of the primary tests of pregnant women.

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Lower prenatal vitamin D status and postpartum depressive symptomatology in African American women: Preliminary evidence for moderation by inflammatory cytokines

Cited by 60 publications

References 80 publications

Serum leptin level measured 48 h after delivery is associated with development of postpartum depressive symptoms: a 3-month follow-up study

Serum leptin level measured 48 h after delivery is associated with development of postpartum depressive symptoms: a 3-month follow-up study

Vitamin D3 attenuates anxiety-like behavior in long-term ovariectomized rats with unpredictable mild stress

The Relationship Between Vitamin D and Postpartum Depression in Reproductive-Aged Iranian Women

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