Vitamin D3 attenuates anxiety-like behavior in long-term
ovariectomized rats with unpredictable mild stress

Baranenko, Denis; Fedotova, Julia; Tol, Annemieke J. M. van den

doi:10.32604/biocell.2019.08407

Cited by 1 publication

(1 citation statement)

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“…VD supplementation can improve anxiety symptoms in depressive patients with low VD levels after 6 months of intervention [ 71 ]. Vitamin D 3 (5.0 mg/kg) administration seems to attenuate the anxiety-like profile in long-term ovariectomized adult rats subjected to chronic unpredictable mild stress [ 72 ]. It is suggested that VD could potentially be used as a therapeutic agent to prevent anxiety in postmenopausal women, and the mechanism of action of l -pyroglutamic acid requires further exploration.…”

Section: Discussionmentioning

confidence: 99%

Association of serum 25-hydroxyvitamin D (25(OH)D) levels with the gut microbiota and metabolites in postmenopausal women in China

et al. 2022

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Background Vitamin D insufficiency or deficiency is associated with an altered microbiota in older men. However, the relationship between the gut microbiota and 25-hydroxyvitamin D (25(OH)D) levels remains unknown in postmenopausal women. In this study, fecal microbiota profiles for 88 postmenopausal women in the high 25(OH)D (HVD) group (n = 44) and the low 25(OH)D (LVD) group (n = 44) were determined. An integrated 16S rRNA gene sequencing and liquid chromatography–mass spectrometry (LC–MS)-based metabolomics approach was applied to explore the association of serum 25(OH)D levels with the gut microbiota and fecal metabolic phenotype. Adjustments were made using several statistical models for potential confounding variables identified from the literature. Results The results demonstrated that the community diversity estimated by the Observe, Chao1 and ACE indexes was significantly lower in the LVD group than in the HVD group. Additionally, two kinds of characteristic differences in the microflora were analyzed in the HVD group, and ten kinds of characteristic differences in the microflora were analyzed in the LVD group. We observed that some bacteria belonging to the genera Bifidobacterium, Bacillus, F0332 and Gemella, were enriched in the LVD group, as were other genera, including Lachnoclostridium, UC5_1_2E3, Ruminococcus_gnavus_group and un_f_Lachnospiraceae. Christensenellaceae, Eggerthellaceae and Cloacibacillus were enriched in the HVD group. The L-pyroglutamic acid, inosine, and L-homocysteic acid levels were higher in the HVD group and were negatively correlated with the 1,2-benzenedicarboxylic acid and cholic acid metabolic levels. Conclusions These observations provide a better understanding of the relationships between serum 25(OH)D levels and the fecal microbiota and metabolites in postmenopausal women.

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Section: Discussionmentioning

confidence: 99%