Low temperature, easy scaling up method for development of smart nanostructure hybrid lipid capsules for drug delivery application

Yadava, Sunil Kumar; Basu, Suparna Mercy; Chauhan, Meenakshi; Sharma, Kshipra; Pradhan, Arpan; Remya, V.; Giri, Jyotsnendu

doi:10.1016/j.colsurfb.2020.110927

Cited by 14 publications

(23 citation statements)

References 36 publications

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“…Sometimes, it is also useful to use UV to polymerise the surfactant layer that caps the NPs to maintain their original sizes [64,65]. The previous literature has highlighted the effects of the surfactant types on the final characteristics of NPs and their influence in controlling their applications [66,67].…”

Section: Chemical Precipitationmentioning

confidence: 99%

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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Designing of nanomaterials has now become a top-priority research goal with a view to developing specific applications in the biomedical fields. In fact, the recent trends in the literature show that there is a lack of in-depth reviews that specifically highlight the current knowledge based on the design and production of nanomaterials. Considerations of size, shape, surface charge and microstructures are important factors in this regard as they affect the performance of nanoparticles (NPs). These parameters are also found to be dependent on their synthesis methods. The characterisation techniques that have been used for the investigation of these nanomaterials are relatively different in their concepts, sample preparation methods and obtained results. Consequently, this review article aims to carry out an in-depth discussion on the recent trends on nanomaterials for biomedical engineering, with a particular emphasis on the choices of the nanomaterials, preparation methods/instruments and characterisations techniques used for designing of nanomaterials. Key applications of these nanomaterials, such as tissue regeneration, medication delivery and wound healing, are also discussed briefly. Covering this knowledge gap will result in a better understanding of the role of nanomaterial design and subsequent larger-scale applications in terms of both its potential and difficulties.

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Section: Chemical Precipitationmentioning

confidence: 99%

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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“…Cryo-SEM was performed to analyze the morphology of LNCs. Sample was prepared as described previously (Yadava et al, 2020). Briefly, 10 µL of a suitable diluted LNCs suspension was mounted onto a carbon tape coated sample holder which was then transferred into the Cryo unit (PP3000T) by Quorum, followed by rapid cooling in liquid nitrogen (-190 °C) for 30 sec under vacuum.…”

Section: Cryo-scanning Electron Microscopy (Cryo-sem)mentioning

confidence: 99%

“…LNCs-PTX (1% w/w to Labrafac) of different sizes were prepared and stored at 4 °C. Samples were aliquoted at regular intervals from day 0 to day 60, followed by passing through the 0.2 µm syringe filter (Yadava et al, 2020). The samples were then dissolved in acetonitrile and the amount of PTX encapsulated within LNCs was quantified by HPLC as described above.…”

Section: Evaluation Of Stabilitymentioning

confidence: 99%

Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells

Valsalakumari

Yadava

Szwed

et al. 2021

International Journal of Pharmaceutics

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“…In vitro drug release profile of PTX from the PPS NPs was determined by dialysis method as reported previously. 30 Desired amount of PPS-PTX NPs suspension (containing equivalent to 300 μg of PTX) was added into PBS (1Â, pH 7.4) containing 0.1% (v/v) Tween 80 and filled into dialysis tube. The tube was further immersed into 20 mL of PBS.…”

Section: In Vitro Drug Release Profilementioning

confidence: 99%

A facile strategy for the preparation of polypropylene sulfide nanoparticles for hydrophobic and base‐sensitive cargo

Chauhan

Basu

Yadava

et al. 2021

J of Applied Polymer Sci

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Polypropylene sulfide (PPS) as reactive oxygen species (ROS) responsive nanoparticles (NPs) have attained great interest for drug delivery applications in many diseases such as cancer, pulmonary, neurovascular, cardiovascular, and age-related diseases. Despite great potential of PPS NPs as a nanocarrier, it remains relatively less explored for small molecules (drug) delivery, as the current method of PPS NPs synthesis involving strong bases like sodium methoxide (NaOMe) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) results in breakdown of base sensitive drugs or molecules. Herein, we are reporting a facile synthesis method for PPS NPs preparation with high drug loading capacity (five times higher than the reported synthesis method) of base-sensitive cargos (Paclitaxel/Dil dye) within the PPS matrix and protection from possible breakdown of drug during synthesis. The NPs prepared via our method possess oxidative-responsive release of drug, preservation of drug bioactivity, and excellent storage stability at room temperature or 4 C. PPS NPs system demonstrate biocompatibility and drug-loaded NPs provide efficient anticancer activity against breast cancer cells. Our method of PPS NPs synthesis is suitable to prepare a delivery system with higher loading capacity of drug and small molecules for different biomedical applications.

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Low temperature, easy scaling up method for development of smart nanostructure hybrid lipid capsules for drug delivery application

Cited by 14 publications

References 36 publications

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells

A facile strategy for the preparation of polypropylene sulfide nanoparticles for hydrophobic and base‐sensitive cargo

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