Low-risk corpus cancer: Is lymphadenectomy or radiotherapy necessary?

Mariani, Andrea; Webb, Maurice J.; Keeney, Gary L.; Haddock, Michael G.; Calori, Giliola; Podratz, Karl C.

doi:10.1067/mob.2000.107335

Cited by 504 publications

(390 citation statements)

References 30 publications

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“…49,50 This is one key factor evaluated in many algorithms for decisionmaking regarding lymphadenectomy in connection with the primary surgical treatment. [51][52][53] …”

Section: Sonographymentioning

confidence: 99%

Improved survival related to changes in endometrial cancer treatment, a 30-year population based perspective

Trovik

Mauland

Werner

et al. 2012

Gynecologic Oncology

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“…49,50 This is one key factor evaluated in many algorithms for decisionmaking regarding lymphadenectomy in connection with the primary surgical treatment. [51][52][53] …”

Section: Sonographymentioning

confidence: 99%

Improved survival related to changes in endometrial cancer treatment, a 30-year population based perspective

Trovik

Mauland

Werner

et al. 2012

Gynecologic Oncology

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“…Even with experienced hands, 36% of pelvic lymph nodes could not be determined using palpation. In addition, abnormal palpation findings for metastatic nodes remained below 30% (Mariani et al, 2000). In one study, 37% of metastatic nodes in EC cases were observed to have diameters below 2mm (Girardi et al, 1993).…”

Section: Risk Factors For Lymph Node Metastases With Endometriamentioning

confidence: 99%

“…The method and extent of lymph node dissection (LND) have not been uniformly defined, and whether LND should be performed or not in EC patients remains controversial even among experts (Creasman et al, 1987;Case et al, 2006;Chan and Kapp 2007;Chi et al, 2008;Neubauer and Lurain 2011;Wilairat et al, 2012). It is not yet clearly known if LND should be performed in all patients (Case et al, 2006;Chi et al 2008), or if it is unnecessary in early stages of the disease (Mariani et al, 2000;Zuurendonk et al, 2006;Benedetti et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Lymph Node Metastases with Endometrial Carcinoma

Çetinkaya¹,

Atalay²,

Bacinoglu³

2014

Asian Pacific Journal of Cancer Prevention

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Background: The purpose of this study was to investigate and evaluate risk factors for lymph node metastases (LNM) in cases of endometrial cancer (EC). Materials and Methods: A retrospective single institution analysis of patients surgically staged for EC at Ankara Oncology Education and Research Hospital from 1996 to 2010 was performed. Roles of prognostic factors, such as age, histological type, grade, depth of myometrial invasion, cervical involvement, peritoneal cytology, and tumor size, in the prediction of LNM were evaluated. Fisher's exact test and logistic regression analysis were used to assess the effects of various factors on LNM. Results: LNM was observed in 22 out of 247 patients (8.9%) and was significantly more common in the presence of tumors of higher grade, deep myometrial invasion (DMI), cervical involvement, size >2cm, and with positive peritoneal cytology. Logistic regression analysis revealed that DMI remained the only independent risk factor for LNM. NPV, PPV, sensitivity, and specificity for satisfying LNM risk were 98.0, 19.5, 86.3, and 65.3%, respectively for DMI. Conclusions: The incidence of LNM is influenced independently by DMI. If data support a conclusion of DMI, LND should be seriously considered.

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“…Remiantis tyrimais, jei pacientė patenka į mažos rizikos grupę, chirurginis endometriumo vėžio gydymas turėtų apsiriboti gimdos pašalinimu su priedais [14,15]. Esant mažos rizikos endometriumo vėžiui, limfadenektomija ne tik neturi svarios įtakos išgyvenamumui ir sergamumui, bet lemia padidėjusį mirtingumą.…”

Section: Parametrai Nusakantys Galimą Navikinio Proceso Plitimą Limfunclassified

Dubens ir paraaortinių limfmazgių pašalinimo svarba gydant ir stadijuojant endometriumo vėžį

Simavičius

Bogužienė

Černauskis

2015

Medicinos Teorija Ir Praktika

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Reikšminiai žodžiai: endometriumo vėžys, limfadenektomija, dubens limfmazgiai, paraaortiniai limfmazgiai, stadijavimas. Nuo 1988 metų endometriumo vėžys stadijuojamas chirurgiškai, tačiau ir po daugybės atliktų tyrimų ir praktikos limfadenektomijos reikšmė esant ankstyvos stadijos endometriumo vėžiui kelia nemažai klausimų. Atlikus chirurginį stadijavimą galima atrinkti pacientes tolesniam adekvačiam adjuvantiniam gydymui. Deja, netikslingai atlikta limfadenektomija lemia didesnį sergamumą ir mirtingumą. Yra atlikta nemažai tyrimų, vertinančių limfadenektomijos reikšmę gydant endometriumo vėžį, vis dėlto rezultatai yra dviprasmiški ir tai kelia daug diskusijų. Pagrindiniai klausimai, susiję su limfmazgių pašalinimu, yra tokie: kaip nuspėti galimą navikinio proceso plitimą limfmazgiuose ir kaip tikslingai atrinkti tas pacientes, kurioms limfmazgių pašalinimas reikalingas. Nors atlikti tyrimai esant ankstyvos stadijos endometriumo vėžiui nepatvirtina limfmazgių pašalinimo naudos, tačiau jų rezultatai kelia nemažai diskusijų. Tikėtina, kad ateityje sarginio limfmazgio identifikavimas išspręs nemažai diskusinių klausimų. Yra žinoma, kad limfadenektomija lemia didesnį sergamumą ir ekonomines išlaidas, tačiau įtaka ilgalaikei gyvenimo kokybei lieka neaiški. Svarbiausi šio straipsnio tikslai ir būtų įvardyti parametrus, lemiančius navikinio proceso plitimą limfmazgiuose, įvardyti sarginio limfmazgio reikšmę bei suprasti netikslingos limfadenektomijos įtaką sergamumui.

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Low-risk corpus cancer: Is lymphadenectomy or radiotherapy necessary?

Cited by 504 publications

References 30 publications

Improved survival related to changes in endometrial cancer treatment, a 30-year population based perspective

Improved survival related to changes in endometrial cancer treatment, a 30-year population based perspective

Risk Factors of Lymph Node Metastases with Endometrial Carcinoma

Dubens ir paraaortinių limfmazgių pašalinimo svarba gydant ir stadijuojant endometriumo vėžį

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