Risk Factors of Lymph Node Metastases with Endometrial Carcinoma

Çetinkaya, Kadir; Atalay, Funda; Bacinoglu, Ahmet

doi:10.7314/apjcp.2014.15.15.6353

Cited by 17 publications

(18 citation statements)

References 25 publications

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“…At G3 CE where DIM was <50% there were 2 positive PLN (15,38%), while when DIM was >50% there were 6 positive PLN registred (26,73%). Muallem MZ et al discovered that when at G3 and with DIM >50%, the risk of PLN metastasis development is 3 -5 times bigger, which matches our stated results ( 13 , 14 ). If the risk rate is low at CE, PLN metastasis rate is low as well and vice versa.…”

Section: Discussionsupporting

confidence: 90%

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Myometrium Invasion, Tumour Size and Lymphovascular Invasion as a Prognostic Factor in Dissemination of Pelvic Lymphatics at Endometrial Carcinoma

Lucic¹,

Draganovic²,

Sibincic³

et al. 2017

Med Arch

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Objective:The aim of this work is to show the importance of the depth of myometrium invasion, tumour size and lymphovascular invasion as prognostic factors in dissemination of lymphatic nodes at endometrial carcinoma (CE).Materials and methods:In the period from 2010 to 2015 at the University Clinic for Gynecology and Obstetrics in Banja Luka, 221 endometrial cancer surgeries were done (laparatomy 184-83%, laparascopy 37-16,74%). Patients who had uterus bleeding in peri/postmenopause or those whose endometrium thickness was bigger than 5 mm which was established by ultrasound, or those who had in their cavum uteri pathological (PH) diagnosis, underwent fractional curettage (FC) or hysteroscopy in order to obtain pathohistological endometrium diagnosis. Substances which were removed by fractional curettage, biopsy or by surgery were sent to patohystological analysis. We analysed the following factors: age (5 groups), histological grade (G) of tumour, depth of myometrial invasion (DIM), whether it is more or less than 50%, the size of the tumour (if it is bigger or smaller than 2 cm), positive or negative lymphovascular invasion (LVI), positive or negative pelvic lymph nodes (PLN).Results:Within histological type the endometrioid type CE 166 (75,11%) was most dominant. Adenocarcinoma of endometrium was present 25 (11,31%), serous CE 11 (4,97%) and clear cell KE 2 (0,90%). Dominant population with CE was over 60 years old 127 (57,46) of female patients. At G3 where DIM was <50% positive PLN were present 2 (3.92%), whereas if DIM was>50%, 6 (26,73%) patients with positive PLN were registred. Tumour size < 2 cm was found with 57 (25,79%) female patients with positive PLN 8 (14,03%), while 164 (74,20%) patients had tumours > 2 cm who had 21 (12,80) PLN metastases. At G1 when tumour was <2 cm, positive PLN had 3 patients (5,88), while when tumour was >2 cm, positive PLN were found at 6 patients (9,69%). At G3 whose size was <2 cm, positive PLN were found at 2 patients (16,66%), but when tumour was >2 cm, PLN metastases were more frequent, 6 (25,00%). Negative LVI was found with 168 patients (76,01%) whose PLN were positive 16 (9,52%), while positive LIV was with 53 patients (23,99%) of whom 14 had PLN metastases (26,41%). At G1 two patients had positive PLN (2,32%) with negative LVI, while with positive LVI, positive PLN were found at 3 patients (11,11%). At G3 having negative LVI positive PLN were found with 6 patients (24,00%), while if LIV was positive, the number of positive PLN were 6 (54,54%).Conclusions:With low risk for lymphatic spread (DIM less than 50%, tumour size smaller than 2 cm and lack of LVI at G1 CE) we also encounter low metastasis rate of PLN. Diagnoses of this kind have an aim to lower the number of pelvic lymphadenectomies. With patients who have a high risk of lymphatic spread (myometrium invasion >50%, tumour size > 2cm, LVI present at G2 and G3) metastasis rate of PLN is high, therefore it is necessary to perform pelvic and paraaortic lymphadenectomy which lowers the mortality rate for more tha...

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Section: Discussionsupporting

confidence: 90%

“…At 164 patients (74,20%) whose tumour was bigger than 2 cm, 21 PLN metastases were registred (12,80%). This result implies that the tumour size is not an independant prognostic factor, as it was pointed out in other researches as well ( 4 , 6 , 14 , 15 ).…”

Section: Discussionsupporting

confidence: 69%

Myometrium Invasion, Tumour Size and Lymphovascular Invasion as a Prognostic Factor in Dissemination of Pelvic Lymphatics at Endometrial Carcinoma

Lucic¹,

Draganovic²,

Sibincic³

et al. 2017

Med Arch

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“…Patients often have postmenopausal uterine bleeding (Acmaz et al, 2014) that help to diagnos in early stages, and those with stage I EC have a survival rate of over 90% (Cetinkaya et al, 2014) however, stage III patients have a 5-year survival rate of around 60-75% (Neubauer and Lurain, 2011). Approximately 90% of endometrial cancers are sporadic, and 10% of them are hereditary (Prat et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

The Polymorphism of Hypoxia-inducible Factor-1a Gene in Endometrial Cancer

Kafshdooz¹,

Tabrizi²,

Mohaddes³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Endometral carcinoma is the most common malignant tumor of the female genital tract and the fourth most common cancer in women after breast, colorectal and lung cancers Hypoxia-inducible factor -1 (HIF-1) is a key transcription factor that regulates cellular response to hypoxia HIF-1 plays important roles in the development and progression of cancer through activation of various genes that are involved in crucial aspects of cancer biology, including angiogenesis, energy metabolism, vasomotor function, erythropoiesis, and cell survival. In this study, we aimed to investigate the association between HIF-1 1772 C/T polymorphisms and endometrial cancer. Materials and Methods: 75 patients with endometrial carcinoma and 75 patients whose underwent hysterectomy for non tumoral indication selected for evaluation of HIF-1 1772 C/T polymorphisms by PCR-RFLP and sequencing. Results: For the 1772 C/T polymorphism, the analysis showed that the T allele and genotype TT were significantly associated with endometrial cancer risk. Conclusions: Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial cancers.

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“…Moreover pelvic lymph node metastasis risk is less than 5% in grade 1-2 tumors if the myometrial invasion is less than 50%; however it is approximately 15% in grade 1-2 tumors if the myometrial invasion is higher than 50% (Creasman et al, 1987). Myometrial invasion is an important predictor of lymph node metastasis (Cetinkaya et al, 2014). Patients have a low risk for nodal metastasis when the tumor size is ≤ 2cm, myometrial invasion is ≤1/2 and grade 1 histology is present.…”

Section: Predicting Lympho-vascular Space Invasion In Endometrial Canmentioning

confidence: 99%

Predicting Lympho-Vascular Space Invasion in Endometrial Cancers with Mucinous Carcinomatous Components

Ilker

Nilufer²,

Firat³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Mean age, BMI and parity were not significantly different between patient groups. Larger tumor diameter (≥2cm) (p=0.04) and elevated Ca125 and Ca-19.9 (p=0.01) levels were significant for predicting LVSI. We also found >1/2 myometrial invasion (p<0.001), cervical stromal involvement (p=0.002) and higher grade (2-3) (p=0.001) significant for predicting LVSI. In multivariate analysis we found only grade significant for predicting LVSI. Conclusions: Especially grade of tumor is a crucial factor for determining LVSI in endometrial cancers with mucinous carcinomatous components.

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Risk Factors of Lymph Node Metastases with Endometrial Carcinoma

Cited by 17 publications

References 25 publications

Myometrium Invasion, Tumour Size and Lymphovascular Invasion as a Prognostic Factor in Dissemination of Pelvic Lymphatics at Endometrial Carcinoma

Myometrium Invasion, Tumour Size and Lymphovascular Invasion as a Prognostic Factor in Dissemination of Pelvic Lymphatics at Endometrial Carcinoma

The Polymorphism of Hypoxia-inducible Factor-1a Gene in Endometrial Cancer

Predicting Lympho-Vascular Space Invasion in Endometrial Cancers with Mucinous Carcinomatous Components

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