Low rate of inflammatory bowel disease in the <scp>A</scp>ustralian indigenous paediatric population

Leach, Steven T.; Day, Andrew S.; Moore, David; Lemberg, Daniel A.

doi:10.1111/jpc.12535

Cited by 7 publications

(13 citation statements)

References 3 publications

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“…The finding that Aboriginal and/or Torres Strait Islanders have a lower risk for developing IBD is consistent with other reports that have demonstrated lower risk of IBD in Indigenous populations [ 22 – 24 ]. Data from the Australian Paediatric and Adolescent IBD Database indicate lower rates of IBD in children of Aboriginal and Torres Strait Islander descent compared to non-Indigenous children [ 24 ]. Evidence from New Zealand demonstrates a lower risk of IBD among the Maori and Pacific Island people compared to Caucasians [ 22 , 23 ].…”

Section: Discussionsupporting

confidence: 92%

Prevalence of inflammatory bowel disease in the Australian general practice population: A cross-sectional study

Busingye¹,

Pollack²,

Chidwick³

2021

PLoS ONE

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The burden of inflammatory bowel disease (IBD) in Australia is increasing but national data about the current prevalence are limited. We aimed to estimate the prevalence of IBD (including Crohn’s disease, ulcerative colitis and unspecified IBD) as well as Crohn’s disease and ulcerative colitis separately in a general practice population in Australia. We also assessed risk factors associated with Crohn’s disease and ulcerative colitis. We conducted a cross-sectional study using data from MedicineInsight, a national database of general practice electronic health records, from 1 July 2017 to 30 June 2019. The prevalence of IBD was calculated and stratified by sociodemographic characteristics. Logistic regression analysis was conducted to assess risk factors associated with Crohn’s disease and ulcerative colitis. The study comprised 2,428,461 regular patients from 481 practices. The estimated crude prevalence of IBD was 653 per 100,000 patients; Crohn’s disease was 306 per 100,000 and ulcerative colitis was 334 per 100,000. Males were independently associated with a lower risk of Crohn’s disease (OR: 0.86; 95% CI: 0.81, 0.90) but a greater risk of ulcerative colitis (OR: 1.12; 95% CI: 1.06, 1.17) than females. Compared to non-smokers, patients who were current smokers were associated with a greater risk of Crohn’s disease (OR: 1.13; 95% CI: 1.04, 1.23) but a lower risk of ulcerative colitis (OR: 0.52; 95% CI: 0.47, 0.57). Other factors positively associated with both Crohn’s disease and ulcerative colitis were age (≥ 25 years), non-Indigenous status and socioeconomic advantage. Our findings provide a current estimate of the prevalence of IBD, Crohn’s disease and ulcerative colitis in a large national general practice population in Australia and an assessment of the factors associated with Crohn’s disease and ulcerative colitis. These data can assist in estimating the health burden and costs, and planning for health services.

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Section: Discussionsupporting

confidence: 92%

Prevalence of inflammatory bowel disease in the Australian general practice population: A cross-sectional study

Busingye¹,

Pollack²,

Chidwick³

2021

PLoS ONE

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“…The key factor of migration influencing disease onset is likely exposure to a different environment than that in the country of origin[ 7 , 73 ]. Additionally, indigenous populations in developed countries have a much lower IBD incidence[ 74 ].…”

Section: Discussionmentioning

confidence: 99%

“…A study conducted in the Sydney area showed much higher rates of IBD in children of Middle-Eastern descent[ 24 ]. In contrast, low rates of IBD were observed in the following indigenous populations: Aborigines and Maori[ 74 ]. Yap et al[ 26 ] calculated the incidence of IBD, CD and UC to be 2.9, 1.9 and 0.5/100000, respectively in NZ, which is at the lower end compared with the incidence in Europe.…”

Section: Discussionmentioning

confidence: 99%

Current global trends in the incidence of pediatric-onset inflammatory bowel disease

Sýkora

Pomahačová

Kreslová

et al. 2018

WJG

294

202

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AIMTo perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease (IBD).METHODSWe systematically searched the MEDLINE (source PubMed), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatric-onset (< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTSIn total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn’s disease (CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis (UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified (IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence (P < 0.05). The risk of IBD is increasing among first-generation of migrant populations.CONCLUSIONGlobally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts.

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“…Other indigenous populations previously studied include Australian Aboriginal and Canadian First Nations, both of which had significantly lower IBD prevalences compared with local nonindigenous populations. 18,19 In Black African populations, the annualised incidence of CD and UC has been reported to be as low as 5.87 and 3.29/100 000, respectively. 20 Meanwhile in Asian populations, the incidence has been reported to be as low as 1.37/100 000; however, the overall prevalence is rising.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease in Waikato, New Zealand: incidence and prevalence

Seleq

Weilert

Fulforth

2023

Internal Medicine Journal

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Background and AimsInflammatory bowel disease (IBD) prevalence is rising globally; however, indigenous groups are underrepresented. Waikato, New Zealand, is a large region with a high proportion of Māori patients. In Canterbury in 2006, 1% of patients with IBD were Māori. We investigated the incidence and prevalence of IBD in Waikato over 10 years.MethodsThis was a retrospective cohort study assessing the incidence and prevalence of IBD between 2009 and 2019. The search strategy included pathology, radiology, Provation, ICD‐10 coding and private clinics, using the keywords: Crohn's, Crohn, ileitis, colitis, ulcerative, inflammatory bowel disease and IBD. Collected data included current age and age at diagnosis, sex, ethnicity and IBD subtype.ResultsThe IBD point prevalence on 31 December 2019 was 375.6/100 000 compared with 293.6/100 000 in 2010, increasing by 27.9%. The annualised incidence was static from 21.5/100 000 in 2010 to 17.5/100 000 in 2019. Female patients comprised 53.3% of the cohort. Ulcerative colitis (UC) made up 54.2% of cases, 43.8% had Crohn disease (CD) and 2.0% had indeterminate colitis. Sixty (3.7%) patients identified as Māori. In non‐Māori patients, the average age at diagnosis was 36.2 years, compared with 33.0 years in Māori patients (P = 0.11). In Māori patients, 53.3% had UC and 45.0% had CD. Thirty‐five percent of Māori patients lived 50 km or more from base hospital, compared with 41% of non‐Māori patients (P = 0.33).ConclusionIBD prevalence has increased substantially; however, the incidence has remained static. Māori IBD rates are higher than previously reported, in keeping with international indigenous trends. Māori patients were diagnosed at a similar age as non‐Māori patients, with similar disease subtypes.

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Low rate of inflammatory bowel disease in the Australian indigenous paediatric population

Cited by 7 publications

References 3 publications

Prevalence of inflammatory bowel disease in the Australian general practice population: A cross-sectional study

Prevalence of inflammatory bowel disease in the Australian general practice population: A cross-sectional study

Current global trends in the incidence of pediatric-onset inflammatory bowel disease

Inflammatory bowel disease in Waikato, New Zealand: incidence and prevalence

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