Low plasma zinc levels in androgenetic alopecia

Aiempanakit, Kumpol; Jandee, Sawangpong; Chiratikarnwong, Kanokphorn; Chuaprapaisilp, Thavatchai; Auepemkiate, Sauvarat

doi:10.4103/ijdvl.ijdvl_680_16

Cited by 9 publications

(9 citation statements)

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“…In the current study, MAGA patients showed serum zinc levels significantly lower than the control group consistent with previous reports . Kil et al showed significantly lower serum zinc level in MAGA patients compared to control but still within normal value limit.…”

Section: Discussionsupporting

confidence: 92%

“…Our study revealed that serum zinc levels showed a nonsignificant correlation as regards the MAGA clinical grades consistent with previous reports . Also, there was a nonsignificant correlation between serum zinc and patients’ age consistent with other reports . We found that serum zinc showed a significant correlation with patients’ BMI.…”

Section: Discussionsupporting

confidence: 91%

“…Kil et al showed significantly lower serum zinc level in MAGA patients compared to control but still within normal value limit. Aiempanakit et al found that serum zinc levels were lower in MAGA patients compared to controls, of note, serum zinc in patients and controls were lower than normal value limit. On the other hand, Ozturk et al who did not detect any significant difference in serum zinc levels between MAGA in Turkish patients and controls ( P = 0.46), but they found significantly lower zinc level in the hairs of MAGA patients.…”

Section: Discussionmentioning

confidence: 92%

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Serum biotin and zinc in male androgenetic alopecia

Elesawy

Hussein

Mansour

2019

J of Cosmetic Dermatology

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Summary Background Male androgenetic alopecia (MAGA) is caused by the conversion of the terminal to vellus hair. Zinc is one of the most studied trace elements in hair disorders and biotin is one of the most prescribed supplement for its treatment. Objectives The study aimed to evaluate serum zinc and biotin levels in MAGA patients to answer the question if there is a value to add zinc or biotin as a supplements in the MAGA treatment. Patients and Methods Sixty MAGA patients and 60 age, sex, and body mass index‐matched healthy volunteers were included. We measured serum biotin and zinc in all participants. Results Zinc (µg/dL) was lower significantly in patients compared to controls (P = 0.01), suboptimal biotin (ng/L) levels were in patients, and within normal values in controls (P = 0.01). A positive significant correlation was found between serum zinc and serum biotin (r = 0.489, P = 0.001). Serum zinc and biotin showed a nonsignificant correlation with age and disease duration. A non‐significant relation was obtained between the MAGA grades, and zinc (P = 0.485) and biotin levels (P = 0.367). Conclusions Serum zinc showed subnormal value and adding zinc supplement in MAGA treatment is recommended. Serum biotin showed a suboptimal level in MAGA patients that is not correlated with patients’ age or disease severity. Biotin supplement in MAGA treatment may add value to hair quality and texture. We recommend future biotin evaluation in serum combined with its metabolites in MAGA patients’ urine.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 92%

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Serum biotin and zinc in male androgenetic alopecia

Elesawy

Hussein

Mansour

2019

J of Cosmetic Dermatology

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“…33 Another study showed that females with the Ludwig clinical pattern had lower plasma zinc levels. 34 Kondrakhina et al 35 in his case-controlled study that enrolled males with androgenetic alopecia, studied many nutrient parameters, however, differences were shown in zinc content only. El Esway et al similarly tested males and demonstrated a similar outcome.…”

Section: Androgenic Alopeciamentioning

confidence: 99%

Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review

et al. 2022

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Zinc is a trace nutrient essential for the normal growth and development of human body. The main aim was to evaluate the significant association between measured zinc status in relation to different skin disorders and their severity. PubMed®, Google® Scholar™ and Cochrane© Reviews databases were searched for studies from January 2017 to June 2021, using the terms; zinc serum levels, zinc plasma levels and different dermatosis in the review, only human studies in English language were reviewed and the studies designs were controlled, cross sectional, observational and analytic types. A total of forty-eight research studies were included in this review. All studies have evaluated serum zinc in skin diseases including psoriasis, atopic dermatitis, pityriasis alba, androgenetic alopecia areata, telogen effluvium, vitiligo, melasma, acne, seborrheic dermatitis and hidradenitis suppuritiva. It was found that 33 studies had validated statistically significant differences in serum zinc levels between patients and controls. There is a predominance of low serum zinc levels in all the dermatoses reviewed. The clinical significance of this finding highlights the possible value, and need to investigate, the use of Zinc supplementation as an adjuvant therapy in the management of chronic inflammatory and autoimmune skin diseases proven to manifest altered zinc levels.

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“…In addition to the regulation of immune functions and hormones, many studies have investigated the potential link between zinc deficiency and hair loss [5][6][7][8] . The effects of zinc on the regulation of hair regrowth are not well established, although the negative effects of zinc deficiency on hair growth are clear.…”

mentioning

confidence: 99%

Induction of Cell Proliferation and Cell Death in Human Follicle Dermal Papilla Cells by Zinc Chloride

Tsai¹,

Wang²,

Chen³

et al. 2019

pharmaceutical-sciences

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Tsai et al.: Zinc Induces Cell Proliferation and Cell Death in HFDPCs In the present investigation, the effects of zinc on the growth of human follicle dermal papilla cells were determined. A higher dose of zinc was found to significantly increase the proliferation of human follicle dermal papilla cells and the expression levels of cell cycle regulatory proteins. However, cell death, an increase in the apoptotic protein Bax, and caspase-3 activation were also observed in zinc-treated human follicle dermal papilla cells. The results from our present study suggest that the regulation of human follicle dermal papilla cells proliferation or death by zinc might be directly involved in hair regrowth in a narrow dose range.

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Low plasma zinc levels in androgenetic alopecia

Cited by 9 publications

References 0 publications

Serum biotin and zinc in male androgenetic alopecia

Serum biotin and zinc in male androgenetic alopecia

Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review

Induction of Cell Proliferation and Cell Death in Human Follicle Dermal Papilla Cells by Zinc Chloride

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