Serum biotin and zinc in male androgenetic alopecia

Elesawy, Fatma Mohamed; Hussein, Mohamed Saber; Mansour, Amira I.

doi:10.1111/jocd.12865

Cited by 18 publications

(11 citation statements)

References 23 publications

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“…There were greater serum levels of biotin with no significant differences between the two groups. In androgenic alopecia (14), two investigations were conducted at blood biotin level one and the other in premature canities (<20 years of age) (15). The findings were similar to ours, as the average blood level of biotin in patients compared to control was considerably lower.…”

Section: Discussionsupporting

confidence: 83%

Evaluation of serum level of biotin and effect of biotin replacement therapy in patients with telegon effluvium

Sabry

Rahman

Awady

et al. 2021

Benha Journal of Applied Sciences

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Background: Biotin is a water-solutions vitamin used for five mammalian carboxylases as an important coenzyme. It has a major role in fatty acids, amino acids and glucose metabolism. It is a popular dietary supplement for the treatment of fragile nails and hair loss. Objectives: The present research aimed at evaluating patients with or without biotin deficiency in telegon effluvium and determining after 3 months the impact of biotin replacement treatment. Methods: 130 patients with Télégon Efluvium (group A) and 120 healthy individuals (group B) served as a control group were studied. Methods: Those subjects who had been subjected to biotin treatment three months before the survey and reported additional hair loss reasons were eliminated. All patients were assessed for hair loss by clinical diagnosis before and after replacement treatment (hair pull test and Dermoscopic evaluation). The biotin level of serum was measured using commercially available immunosorbent assay kits. Results: Mean biotin serum levels were lower than controls between the two groups in a group. The impact of biotin replacement treatment has shown that better cases are 51.5%, improved cases are 34.6% and missing cases 13.8%. Patients with insufficient serum biotin levels were substantially improved, while non-improved cases with optimum blood biotin concentrations were significantly identified. Conclusion: Our results indicate that biotin addition had a substantial impact on hair loss, particularly in individuals with telegon effluvium who had deficiencies or inadequate biotin levels.

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Section: Discussionsupporting

confidence: 83%

Evaluation of serum level of biotin and effect of biotin replacement therapy in patients with telegon effluvium

Sabry

Rahman

Awady

et al. 2021

Benha Journal of Applied Sciences

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“…We speculate that this discrepancy might be attributable for the duration of BnD. Reduced serum biotin and zinc levels have been recently reported in patients with male androgenetic alopecia, suggesting the close association between biotin and zinc [32]. We investigated how dietary BnD led to ZnD but the precise mechanisms could not be elucidated (data not shown).…”

Section: Discussionmentioning

confidence: 98%

Biotin Is Required for the Zinc Homeostasis in the Skin

et al. 2019

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Patients with biotin deficiency present symptoms that are similar to those in patients with acrodermatitis enteropathica (inherent zinc deficiency). However, the association between biotin and zinc deficiency remains unknown. We have previously shown that epidermal keratinocytes of mice fed zinc-deficient (ZD) diets secreted more adenosine triphosphate (ATP) than those of mice fed zinc-adequate (ZA) diets and that epidermal Langerhans cells are absent in ZD mice. Langerhans cells highly express CD39, which potently hydrolyzes ATP into adenosine monophosphate (AMP). Thus, a lack of Langerhans cells in ZD mice leads to non-hydrolysis of ATP, thereby leading to the development of ATP-mediated irritant contact dermatitis. In this study, we examined if biotin-deficient (BD) mice showed the same underlying mechanisms as those in ZD mice. BD mice showed reduced serum zinc levels, disappearance of epidermal Langerhans cells, and enhanced ATP production in the skin. Consequently, irritant contact dermatitis was significantly enhanced and prolonged in BD mice. In conclusion, the findings of our study showed that biotin deficiency leads to zinc deficiency because of which patients with biotin deficiency show similar symptoms as those with acrodermatitis enteropathica.

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“…It has long been suggested that Zn plays an important role in hair loss [7]. A number of studies have shown reduced serum Zn in individuals with AGA [28,29]. Rahman and Akhter showed that lower serum levels of zinc (75.41 ± 9.47 vs 99.97 ± 7.72 µg/dl in the controls) and copper (74.55 ± 9.65 vs 100.23 ± 10.95 µg/dl in the controls) may be associated with alopecia regardless of gender, and an assessment of serum Zn and Cu concentrations may be useful for the correct treatment of alopecia [30].…”

Section: Discussionmentioning

confidence: 99%

Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness

et al. 2020

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Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5% topical minoxidil joints with corrections for trace element and vitamin imbalances. In most cases, the positive therapy’s effect was shown in the parietal but not in the occipital area, whereas that effect was observed in others. The attempts to associate the therapy’s effectiveness with initially defined genetic, hormonal, and metabolic parameters showed the absence of differences between groups with positive and negative outcomes. Among the studied nutrient parameters (Zn, Cu, Mg, Ca, Fe, and Se, as well as vitamins B12, E, D, and folic acid), differences between these groups was shown in zinc content only. The starting point from a zinc plasma level above 10 µmol/L likely provides the success of the subsequent conservative therapy and correlates with an increase in the hair density and diameter in the parietal area. The integral predictive value of the Zn plasma level was assessed as 72.3% (positive predictive value: −88%; and negative predictive value: −55%).

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Serum biotin and zinc in male androgenetic alopecia

Cited by 18 publications

References 23 publications

Evaluation of serum level of biotin and effect of biotin replacement therapy in patients with telegon effluvium

Evaluation of serum level of biotin and effect of biotin replacement therapy in patients with telegon effluvium

Biotin Is Required for the Zinc Homeostasis in the Skin

Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness

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