Induction of Cell Proliferation and Cell Death in Human Follicle Dermal Papilla Cells by Zinc Chloride

Tsai, Fu-Ming; Wang, L. K.; Chen, M. L.; Lee, M. C.; Lin, Yangyang; Wang, C. N.

doi:10.36468/pharmaceutical-sciences.570

Cited by 2 publications

(2 citation statements)

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“…An increase in the apoptotic Bax protein and caspase-3 activation were observed. The results of this study suggest that zinc is involved in the regulation of proliferation or death of human dermal papilla cells in the follicle, but in a narrow dose range [33]. The fact that Zn plasma levels in the positive effect and absence of effect groups were equal upon completion of conservative treatment most likely indicates the prognostic significance of the initial Zn plasma level in relation to the effectiveness of conservative therapy, but not a decisive role in realizing the positive effect of treatment.…”

Section: Discussionmentioning

confidence: 78%

“…At the same time, the concentration dependence of zinc on the proliferation of the dermal papilla cells of a human follicle and the expression of regulatory proteins of the cell cycle have also been demonstrated. Tsai et al reported that zinc chloride at a dose of 200-500 nmol significantly increases the proliferation of human follicle dermal papilla cells and the expression of cell cycle regulatory proteins [33]. However, the production of proteins associated with the cell cycle has decreased when the cells were treated with 1000 nmol zinc chloride.…”

Section: Discussionmentioning

confidence: 99%

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Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness

et al. 2020

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Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5% topical minoxidil joints with corrections for trace element and vitamin imbalances. In most cases, the positive therapy’s effect was shown in the parietal but not in the occipital area, whereas that effect was observed in others. The attempts to associate the therapy’s effectiveness with initially defined genetic, hormonal, and metabolic parameters showed the absence of differences between groups with positive and negative outcomes. Among the studied nutrient parameters (Zn, Cu, Mg, Ca, Fe, and Se, as well as vitamins B12, E, D, and folic acid), differences between these groups was shown in zinc content only. The starting point from a zinc plasma level above 10 µmol/L likely provides the success of the subsequent conservative therapy and correlates with an increase in the hair density and diameter in the parietal area. The integral predictive value of the Zn plasma level was assessed as 72.3% (positive predictive value: −88%; and negative predictive value: −55%).

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%