Low picomolar, instrument-free visual detection of mercury and silver ions using low-cost programmable nanoprobes

Rana, Muhit; Balcioglu, Mustafa; Robertson, Neil; Hizir, Mustafa Salih; Yumak, Sumeyra; Yigit, Mehmet V.

doi:10.1039/c6sc03444f

Cited by 48 publications

(38 citation statements)

References 43 publications

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“…C) Schematic illustration of Hg 2+ and Ag + detection in water, soil and urine samples using the gold nanoprobe array. Reproduced with permission from reference . Copyright 2017, Royal Society of Chemistry.…”

Section: Dna‐mediated Aunp Assemblies For Bioanalysismentioning

confidence: 99%

“…b, Altering cellular uptake properties of the nanoparticle assemblies by shape change;s cale bars, 2.0 mm( low magnification images) and 100 nm (enlarged images). Reproduced with permission from reference[99].Copyright 2016, American Associationfor the AdvancementofS cience.C )Schematic illustration of Hg 2 + and Ag + detectioni nw ater,s oiland urine samplesu sing the gold nanoprobe array.R eproduced with permission from reference[100]. Copyright2 017, Royal SocietyofC hemistry.…”

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confidence: 99%

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DNA‐Mediated Assembly of Gold Nanoparticles and Applications in Bioanalysis

et al. 2017

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DNA-mediated gold nanoparticles (AuNPs) assembly has drawn great attentiond ue to the controllable parameters and properties. In general,D NA sequences working as linkerso rt emplates precisely controlt he assembly of AuNPs throught he Watson-Crick base pairing. Diverse assembly structures show great potential in bioanalysis due to the uniqueo ptical characteristics, which can be tuned by the shape, size, composition, particles interactive statusa nd the dielectric constant of the surrounding mediumo f AuNPs.T hey exhibit excellent performances for the detection of nucleic acids, proteins, small molecules and other biomarkers. In this review,w ep resentageneral overview of the construction of DNA-mediated AuNP assemblies and the recent advances of these assemblies as high-performance biosensors. Future directions and major challenges in bioanalysisare also discussed.

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Section: Dna‐mediated Aunp Assemblies For Bioanalysismentioning

confidence: 99%

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confidence: 99%

DNA‐Mediated Assembly of Gold Nanoparticles and Applications in Bioanalysis

et al. 2017

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“…3 However, the extensive consumption of Ag has led it to become one of the most prevalent environmental pollutants. 4,5 Therefore, there is great urgency to develop a simple, sensitive, selective and effective strategy to quantitatively analyze Ag + in the surrounding environment.…”

Section: Introductionmentioning

confidence: 99%

A Fluorescence Strategy for Silver Ion Assay via Cation Exchange Reaction and Formation of Poly(thymine)-templated Copper Nanoclusters

Wang

et al. 2019

ANAL. SCI.

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The detection of Ag + ions in the environment and biological systems is important to both environmental monitoring and modern medicine. Herein, a novel and label-free method was developed for Ag + detection, which utilizes a florescence strategy combining DNA-templated copper nanoclusters (Cu NCs) with cation exchange reactions. The method is primarily based on the effective detection of an Ag +-triggered cation exchange reaction and the release of free Cu 2+ from CuS nanoparticles (CuS NPs), while the probe T30 serves as an effective template for the formation of fluorescenceinducing Cu NCs. Under optimal conditions, this sensing system displays high sensitivity with a 50 nM limit of detection and a range from 0-100 μM. In addition, the proposed method exhibits high selectivity and, therefore, was successfully applied to the analysis of real samples. Overall, these results demonstrate that our established method has advantages of design and operation simplicity, as well as cost-effectiveness.

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“…On this basis, many new methods for detecting Hg 2+ and Ag + have been proposed, such as the G-quadruplexes detection method [ 32 , 33 ], the fluorescence detection method [ 34 , 35 ], the electrochemical detection method [ 11 , 36 , 37 , 38 , 39 ], the DNA-modified gold nanoparticles detection method [ 11 , 16 , 21 , 40 ], the colorimetry detection method [ 41 , 42 ] and the probe microscope detection method [ 43 ]. These methods have the advantages of low cost, high efficiency, time efficiency, simple operation, high sensitivity, and specificity, and they completely overcome the disadvantages of traditional detection methods [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional Molecular Probe for Detecting Hg2+ and Ag+ Based on Ion-Mediated Base Mismatch

Wang

Zhang

Dong

2018

Sensors

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In this paper, a multifunctional biosensing platform for sensitively detecting Hg2+ and Ag+, based on ion-mediated base mismatch, fluorescent labeling, and strand displacement, is introduced. The sensor can also be used as an OR logic gate, the multifunctional design of sensors is realized. Firstly, orthogonal experiments with three factors and three levels were carried out on the designed sensor, and preliminary optimization of conditions was performed for subsequent experiments. Next, the designed sensor was tested the specificity and target selectivity under the optimized conditions, and the application to actual environmental samples further verified the feasibility. Generally, this is a convenient, fast, stable, and low-cost method that provides a variety of ideas and an experimental basis for subsequent research.

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Low picomolar, instrument-free visual detection of mercury and silver ions using low-cost programmable nanoprobes

Abstract: A single gold nanoprobe can be programmed for low picomolar visual detection of inorganic mercury and/or silver in water, soil or urine samples.

Cited by 48 publications

References 43 publications

DNA‐Mediated Assembly of Gold Nanoparticles and Applications in Bioanalysis

DNA‐Mediated Assembly of Gold Nanoparticles and Applications in Bioanalysis

A Fluorescence Strategy for Silver Ion Assay via Cation Exchange Reaction and Formation of Poly(thymine)-templated Copper Nanoclusters

A Multifunctional Molecular Probe for Detecting Hg2+ and Ag+ Based on Ion-Mediated Base Mismatch

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