Low Oxygen Consumption is Related to a Hypomethylation and an Increased Secretion of IL-6 in Obese Subjects with Sleep Apnea-Hypopnea Syndrome

Lopez‐Pascual, Amaya; Lasa, Arrate; Portillo, Marı́a P.; Arós, Fernando; Mansego, María Luisa; González‐Muniesa, Pedro; Martínez, J. Alfredo

doi:10.1159/000478276

Cited by 8 publications

(7 citation statements)

References 55 publications

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“…Our results confirm that lower sleep efficiency was associated with higher circulating levels of IL-6 in midlife women 23. Elevated inflammatory cytokines in patients can lead to various forms of sleep disturbance in other diseases, such as schizophrenia,32 sleep apnea-hypopnea syndrome (SAHS),33 type 2 diabetes, and cardiovascular events 34. Because inflammatory responses can be triggered by obesity, hypoxia, and hyperlipidemia, levels of proinflammatory factors may be elevated.…”

Section: Discussionsupporting

confidence: 74%

<p>The level of IL-6 was associated with sleep disturbances in patients with major depressive disorder</p>

Wang¹,

Wei²,

Yang³

et al. 2019

NDT

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Purpose: Major depression disorder (MDD) was associated with inflammatory processes, but association results of inflammatory syndrome and MDD were inconsistent. To provide more evidence, we measured the plasma levels of IL-1β, IL-6, interferon (INT)-α2, INT-γ, and tumor necrosis factor (TNF)-α in patients having MDD and explored correlations between the five proinflammatory cytokines and specific depressive symptoms. Patients and methods: Plasma concentrations of IL-1β, IL-6, INT-α2, INT-γ, and TNF-α were measured using ELISA for 44 MDD patients and 54 healthy controls. Patients with MDD were assessed on the 17-item Hamilton Depression Rating Scale (HAMD-17), and a total score and five syndrome scores were acquired. Results: IL-6 levels in depressed patients were significantly elevated than in healthy controls, but no significant differences were observed in the levels of INF-α2, INF-γ, IL-1β, or TNF-α. In addition, correlation analysis revealed that sleep disturbances positively correlated with IL-6. Although there was no significant difference between the two groups in the levels of INF-α2, a significant positive correlation between IFN-α2 and retardation was observed. Conclusion: Elevated IL-6 levels were observed in MDD patients and IL-6 may correlate with sleep disturbances.

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Section: Discussionsupporting

confidence: 74%

<p>The level of IL-6 was associated with sleep disturbances in patients with major depressive disorder</p>

Wang¹,

Wei²,

Yang³

et al. 2019

NDT

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“…The role of hypoxia as a main inducing factor of inflammation has been elucidated in recent years [189]. For example, low oxygen consumption was associated with IL6 gene hypomethylation and increased serum IL-6 concentrations in obese subjects with sleep apnea-hypopnea syndrome [190]. A mechanistic role of inflammasome activation in determining aerobic capacity (measured by peak oxygen uptake) was suggested since the percentage of methylation of the ASC gene and plasma IL-1β levels correlated with aerobic capacity in stable outpatients with heart failure [191].…”

Section: Climatementioning

confidence: 99%

Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition

et al. 2020

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Aim and objective Emerging translational evidence suggests that epigenetic alterations (DNA methylation, miRNA expression, and histone modifications) occur after external stimuli and may contribute to exacerbated inflammation and the risk of suffering several diseases including diabetes, cardiovascular diseases, cancer, and neurological disorders. This review summarizes the current knowledge about the harmful effects of high-fat/high-sugar diets, micronutrient deficiencies (folate, manganese, and carotenoids), obesity and associated complications, bacterial/viral infections, smoking, excessive alcohol consumption, sleep deprivation, chronic stress, air pollution, and chemical exposure on inflammation through epigenetic mechanisms. Additionally, the epigenetic phenomena underlying the anti-inflammatory potential of caloric restriction, n-3 PUFA, Mediterranean diet, vitamin D, zinc, polyphenols (i.e., resveratrol, gallic acid, epicatechin, luteolin, curcumin), and the role of systematic exercise are discussed. Methods Original and review articles encompassing epigenetics and inflammation were screened from major databases (including PubMed, Medline, Science Direct, Scopus, etc.) and analyzed for the writing of the review paper. Conclusion Although caution should be exercised, research on epigenetic mechanisms is contributing to understand pathological processes involving inflammatory responses, the prediction of disease risk based on the epigenotype, as well as the putative design of therapeutic interventions targeting the epigenome.

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“…Noteworthy is that this report provides information on lower oxygen consumption at rest in obesity and cardiovascular disease (CVD). In this regard, low oxygen consumption was associated with systemic inflammation in obese men with SAHS (223). The measurement of basal oxygen consumption is an easy to perform, non-invasive and affordable approach, which other than in the particular study, is not commonly used to differentiate between metabolically healthy individuals and those with metabolic disorders.…”

Section: Oxygen Deliverymentioning

confidence: 99%

“…In addition, aging is commonly associated with higher systemic levels of pro-inflammatory factors, such as CRP, IL-6 and TNF-α (294). Previous studies have described a link between DNA methylation and the aging process (65,127,223,231,329,370). Nevertheless, aging-induced differential methylation occurs mostly without changes in gene expression (370).…”

Section: A Metabolic Disorders and Methylationmentioning

confidence: 99%

Oxygen in Metabolic Dysfunction and Its Therapeutic Relevance

Lopez‐Pascual

Trayhurn

Martínéz

et al. 2021

Antioxidants & Redox Signaling

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Significance: In recent years, a number of studies have shown altered oxygen partial pressure at a tissue level in metabolic disorders, and some researchers have considered oxygen to be a (macro) nutrient. Oxygen availability may be compromised in obesity and several other metabolism-related pathological conditions, including sleep apnea-hypopnea syndrome, the metabolic syndrome (which is a set of conditions), type 2 diabetes, cardiovascular disease and cancer.Recent Advances: Strategies designed to reduce adiposity and its accompanying disorders have been mainly centered on nutritional interventions and physical activity programs. However, novel therapies are needed since these approaches have not been sufficient to counteract the worldwide increasing rates of metabolic disorders. In this regard, intermittent hypoxia training and hyperoxia could be potential treatments through oxygen-related adaptations. Moreover, living at high altitude may have a protective effect against the development of abnormal metabolic conditions. In addition, oxygen delivery systems may be of therapeutic value for supplying the tissue-specific oxygen requirements.Critical Issues: Precise in vivo methods to measure oxygenation are vital to disentangle some of the controversies related to this research area. Furthermore, it is evident that there is a growing need for novel in vitro models to study the potential pathways involved in metabolic dysfunction in order to find appropriate therapeutic targets.Future directions: Based on the existing evidence, it is suggested that oxygen availability has a key role in obesity and related comorbidities. Oxygen should be considered in relation to potential therapeutic strategies in the treatment and prevention of metabolic disorders.

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Low Oxygen Consumption is Related to a Hypomethylation and an Increased Secretion of IL-6 in Obese Subjects with Sleep Apnea-Hypopnea Syndrome

Cited by 8 publications

References 55 publications

<p>The level of IL-6 was associated with sleep disturbances in patients with major depressive disorder</p>

<p>The level of IL-6 was associated with sleep disturbances in patients with major depressive disorder</p>

Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition

Oxygen in Metabolic Dysfunction and Its Therapeutic Relevance

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