Low molecular weight PEG–PLGA polymers provide a superior matrix for conjugated polymer nanoparticles in terms of physicochemical properties, biocompatibility and optical/photoacoustic performance

Abstract

Low molecular weight PEG-PLGA improves optical and photoacoustic properties of PCPDTBT nanoparticles.

The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

“…Polyethylene glycol (PEG) is a degradable polymer made up of repeated ethylene glycol units [-(CH 2 CH 2 O) n ], which can effectively reduce aggregation as a coating of NPs. The modification of low molecular weight PEG helped to maintain a smaller particle size, while the modification of high molecular weight PEG made the NPs more stable in vivo (Morgenstern et al 2017 ; Abelha et al 2019 ). Recently, Kumar et al using potassium permanganate as manganese source and poly(allyl amine) hydrochloride (PAH) as reducing agent, prepared manganese dioxide NPs with particle size of 12.85 nm, and increased its stability by conjugating with PEG (Kumar et al 2019 ).…”

Adjudin-loaded redox-sensitive paclitaxel-prodrug micelles for overcoming multidrug resistance with efficient targeted Colon cancer therapy

“…As shown in Supplementary Figure S10 , the rate of hemolysis rate increased as the concentration of micelles increased, and the rate of hemolysis (for all drug-loaded micelles) remained lower than 5% as the concentration of PTX rose from 0.5 µg/mL to 200 µg/mL. According to the standards recommended by the American Society for Testing and Materials (ASTM E2524-08), a hemolysis rate lower than 5% indicates good levels of hemocompatibility (Lucky et al., 2016 ; Abelha et al., 2019 ). These data demonstrate that the micelles have high levels of hemocompatibility.…”

Conjugated polymers as nanoparticle probes for fluorescence and photoacoustic imaging

“…Besides facilitating the formation of nanoparticles and ensure their colloidal stability, coating agents may also be used to provide a neutral charge to CPNs 133 and to enable bioconjugation with targeting molecules 92,133 . Overall, CPNs have been prepared with varied material composition, which includes lipids 3,19,88,93,134 proteins 100,135 , polymers 94,132,136 and surfactants 85,97 .…”

“…For example, while fabrication conditions might not affect the size and shape of CPNs, it has been shown to have an impact on their spectroscopic properties 148 . In another example, the PEG-PLGA molecular weight influenced PCPDTBT photoacoustic properties, with low molecular weight PLGA (5 kDa) showing improved photoacoustic performance compared to 15 kDa or 55 kDa PLGA 136 .…”