The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

Luo, Junchao; Zhang, Yin; Zhu, Senbo; Ji, Lichen; Zhang, Wei; Zhang, Qiong; Bi, Qing

doi:10.1007/s00210-021-02131-0

Cited by 27 publications

(17 citation statements)

References 100 publications

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“…Nanoparticles have good in vivo stability and cell uptake efficiency, and are widely used for drug delivery. Metal/metal oxide nanoparticles can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide [ 2 , 3 , 4 ]. The degradation of metal/metal oxide nanoparticles releases metal ions and inhibits inflammation [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential.

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Section: Introductionmentioning

confidence: 99%

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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“…5A, mMH could attenuate the inhibition ability of PI3K/Akt/mTOR signal induced by EVL thereby encouraging endothelial cell protection. Furthermore, MH facilitates ROS scavenging to enhance endothelial cell viability [40,41]. The released free Mg 2+ ions from mMH can play as a radical scavenger for the hydroxyl radical and superoxide anions released by PLLA [13,42].…”

Section: Discussionmentioning

confidence: 99%

Reduced restenosis and enhanced re-endothelialization of functional biodegradable vascular scaffolds by everolimus and magnesium hydroxide

et al. 2022

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Background Coronary artery disease is a cardiovascular disease with a high mortality and mortality rate in modern society. Vascular stent insertion to restore blood flow is essential to treat this disease. A fully biodegradable vascular scaffold (BVS) is a vascular poly (L-lactic acid) (PLLA) stent that is receiving growing interest as this is biodegradable in the body and does not require secondary removal surgery. However, acidic byproducts composed of PLLA produced during the biodegradation of the BVS can induce an inflammatory response. Magnesium hydroxide, a basic inorganic particle, neutralizes the acidic byproducts of PLLA. Methods In this study, we investigated using a BVS coated with everolimus and surface-modified magnesium hydroxide that suppresses smooth muscle cell proliferation and protects endothelial cells, respectively. The various characteristics of the functional stent were evaluated using in vitro and in vivo analyses. Results The BVS was successfully prepared with evenly coated everolimus and surface-modified magnesium hydroxide. A neutral pH value was maintained by magnesium hydroxide during degradation, and everolimus was released for one month. The coated BVS effectively inhibited protein adsorption and platelet adhesion, demonstrating excellent blood compatibility. In vitro analysis showed that BVS protects endothelial cells with magnesium hydroxide and selectively inhibits smooth muscle cell proliferation via everolimus treatment. The functional BVS was inserted into porcine coronary arteries for 28 days, and the results demonstrated that the restenosis and inflammation greatly decreased and re-endothelialization was enhanced as compared to others. Conclusions This study provides new insights into the design of drug-incorporated BVS stent for coronary artery disease. Graphical Abstract

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“…MOFs assembled by metal ions and organic connectors possess the advantages of large pore volume, high specific surface area, and hydrophilicity, which can enhance the performance of tissue scaffolds. In addition, these types of MOFs have great potential for tissue repair and regeneration ( Chen J. et al, 2020 ; Luo et al, 2021 ; Yang et al, 2022 ). It has been established that motion-driven electromechanical stimulation of tendon tissue by ferroelectric nanofibers can modulate ion channels and specific tissue regeneration signaling pathways in vitro ( Fernandez‐Yague et al, 2021 ).…”

Section: Nanofiber-based Scaffoldsmentioning

confidence: 99%

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Zhu

He²,

Ji³

et al. 2022

Front. Bioeng. Biotechnol.

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The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration.

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The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

Cited by 27 publications

References 100 publications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Reduced restenosis and enhanced re-endothelialization of functional biodegradable vascular scaffolds by everolimus and magnesium hydroxide

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

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