Conjugated polymers as nanoparticle probes for fluorescence and photoacoustic imaging

Abelha, Thais Fedatto; Dreiss, Cécile A.; Green, Mark; Dailey, Lea Ann

doi:10.1039/c9tb02582k

Cited by 61 publications

(70 citation statements)

References 185 publications

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“…Conjugated polymers are highly versatile materials used as bioimaging agents, [1][2][3] chemical sensors, [4][5][6] and components in electronic devices [7][8][9] including solar cells. 10 Their versatility stems from tunable optoelectronic properties.…”

Section: Introductionmentioning

confidence: 99%

Effect of curvature and placement of donor and acceptor units in cycloparaphenylenes: a computational study

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Effect of curvature and placement of donor and acceptor units in cycloparaphenylenes: a computational study

et al. 2020

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“…To improve the imaging performance, FL and PA imaging techniques usually work together implementing the dual‐modality imaging technique. [ 10 ] However, for clinical applications, both FL and PA imaging face the problem of limited tissue penetration depth. For FL imaging, adopting fluorescent agents with further emission can be an effective approach.…”

Section: Introductionmentioning

confidence: 99%

Near‐Infrared Fluorescence/Photoacoustic Agent with an Intensifying Optical Performance for Imaging‐Guided Effective Photothermal Therapy

Huang

et al. 2020

Advanced Therapeutics

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Near-infrared fluorescent agents generally exhibit typical push-pull electron characteristics, and their optical behaviors are closely related to their molecular structures. Benzobisthiadiazole moiety as a classic electron acceptor has been typically used to design the Donor-Acceptor-Donor (D-AD) type of fluorescent/photoacoustic agents with emission in the second near-infrared window. In this work, two strategies are examined to intensify their absorption/fluorescence and fluorescence/photoacoustic imaging performance: 1) the conjugated bridges are amplified by installing two electron-rich thiophenes and one styrene on two sides of the benzobisthiadiazole core and 2) the N,N-dimethylamino group is employed to replace the traditional diphenylamine to strengthen the electron donor. This agent shows the maximum absorption and fluorescence emission at 942 and 1302 nm, respectively. Its superior in vitro and vivo data confirms that the nanoparticles of this compound complexed with 1,2-distearoyl-sn-glycero-3phosphoethanolamine-N-[methoxy(polyethyleneglycol)] (DSPE-PEG) can not only perform real-time and high-contrast noninvasive near-infrared fluorescence/photoacoustic imaging of tumors (980 nm laser irradiation) but also effectively ablate the tumor cells by photothermal therapy implementing the dual-modality imaging method. In particular, its longer wavelength absorption and emission successfully improves the fluorescence/ photoacoustic imaging performance. These observations highlight its potential to be used as a promising therapeutic platform for cancer.

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“…Polymer nanocarriers have outstanding advantages in terms of biocompatibility, tailoring capabilities, stability, biodegradability, and low cost of preparation, compared to inorganic nanomaterials [ 215 ]. Stimulus-responsive polymers (smart polymers) are highly efficient polymers which adjust to their environment.…”

Section: Stimuli-responsive Polymeric Nanocarriers For Bioimagingmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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Conjugated polymers as nanoparticle probes for fluorescence and photoacoustic imaging

Abstract: In this review, the role of conjugated polymer nanoparticles (CPNs) in emerging bioimaging techniques is described.

Cited by 61 publications

References 185 publications

Effect of curvature and placement of donor and acceptor units in cycloparaphenylenes: a computational study

Effect of curvature and placement of donor and acceptor units in cycloparaphenylenes: a computational study

Near‐Infrared Fluorescence/Photoacoustic Agent with an Intensifying Optical Performance for Imaging‐Guided Effective Photothermal Therapy

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

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