2011
DOI: 10.1007/s10552-011-9774-z
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Low levels of apolipoprotein A-I and HDL are associated with risk of prostate cancer in the Swedish AMORIS study

Abstract: Our results show that low HDL and ApoA-I as well as increased lipid ratios are related to increased PCa risk. Experimental studies are required to tease out the underlying biological mechanisms linking these lipid components to PCa.

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Cited by 61 publications
(77 citation statements)
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“…Moreover, several other pathways that are considered vital for carcinogenesis, such as the sonic hedgehog and Akt pathways, are also cholesterol-sensitive [39,40]. Apo A is the major component of HDL particles [41] and can reduce the levels of free TNF-α, which results in attenuated tumor formation [42]. Low levels of Apo A may therefore contribute to inflammatory processes linked to tumor biology.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Moreover, several other pathways that are considered vital for carcinogenesis, such as the sonic hedgehog and Akt pathways, are also cholesterol-sensitive [39,40]. Apo A is the major component of HDL particles [41] and can reduce the levels of free TNF-α, which results in attenuated tumor formation [42]. Low levels of Apo A may therefore contribute to inflammatory processes linked to tumor biology.…”
Section: Discussionmentioning
confidence: 99%
“…For example, low Apo A levels were found to be associated with a higher risk of breast cancer [43], and for ovarian cancer, Apo A is one of the biomarkers that was shown to potentially improve early detection [44]. Apo A is more strongly linked to prostate cancer risk than Apo B [41], and we did not find any evidence for an association between pancreatic adenocarcinoma and other lipid components (Apo B, Tri, or LDL). However, it is possible that there are distinct etiological relationships between lipid profiles and pancreatic adenocarcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…Coefficients of variation (CV) for these replicate samples were 2.2 % for total cholesterol, 2.2 % for LDL cholesterol, and 1.5 % for HDL cholesterol. Non-HDL cholesterol, which has been examined in other studies of cholesterol and prostate cancer [11,28], was calculated by subtracting HDL cholesterol from total cholesterol.…”
Section: Cholesterol Measurementmentioning
confidence: 99%
“…Dyslipidaemia associated with the metabolic syndrome, including increased triglycerides and LDL and decreased HDL, is also associated with increased prostate cancer risk [1113], and cholesterol-lowering medications such as statins are currently believed to exert most of their positive effects via systemic reductions in total cholesterol [14]. Both dietary and de novo synthesis of free fatty acids have been shown to promote prostate cancer cell survival [15, 16], but studies which characterise fatty acid profiles in prostate disease remain controversial [17, 18].…”
Section: Prostate Cancer and The Metabolic Syndromementioning
confidence: 99%