2012
DOI: 10.1007/s10552-012-0006-y
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Plasma total, LDL, and HDL cholesterol and risk of aggressive prostate cancer in the Cancer Prevention Study II Nutrition Cohort

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Cited by 31 publications
(32 citation statements)
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“…Cancer Epidemiol Biomarkers Prev; 24(7) July 2015 Cancer Epidemiology, Biomarkers & Preventionand 10 cohort studies) were included in this analysis (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). In the 14 included studies, the retrospective cohort study by Farwell and colleagues (18) was also included because it prospectively measured serum cholesterol levels.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Cancer Epidemiol Biomarkers Prev; 24(7) July 2015 Cancer Epidemiology, Biomarkers & Preventionand 10 cohort studies) were included in this analysis (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). In the 14 included studies, the retrospective cohort study by Farwell and colleagues (18) was also included because it prospectively measured serum cholesterol levels.…”
Section: Resultsmentioning
confidence: 99%
“…Some epidemiologic studies and preclinical models also suggest that high levels of cholesterol in blood may be associated with the risk of prostate cancer (6). However, the findings from these epidemiologic studies are inconsistent (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23), as some studies have reported that high levels of cholesterol increased risk of prostate cancer (15,16,18), and some studies have reported no association between cholesterol and risk of prostate cancer (10-14, 17, 19, 21-23). Moreover, high cholesterol has been proposed to be closely associated to late-stage prostate cancer, and cholesterol may play a promotional role in late-stage prostate cancer development and progression (11,15,18,19).…”
Section: Introductionmentioning
confidence: 99%
“…While epidemiologic evidence does not support an association between serum cholesterol levels and risk of total PC [8, 9], there is a suggestion that elevated cholesterol may be associated with increased risk of aggressive disease [8, 1012], although not all studies have reported this finding [9, 1315]. There is mixed evidence for an association between serum cholesterol levels and risk of PC progression, with some studies reporting positive associations between elevated cholesterol and risk of PC recurrence [16] and mortality [17, 18], while another study reported no association with risk of PC mortality [19].…”
Section: Introductionmentioning
confidence: 99%
“…Fewer studies examined the association between cholesterol subfractions —low and high density lipoprotein (LDL and HDL, respectively) — and PC. While there is some evidence that elevated LDL [12, 20] and low HDL [10, 21] are associated with increased risk of aggressive PC, not all studies reported these findings [13, 15, 22], and the association between cholesterol subfractions and risk of PC recurrence has not been widely studied. Finally, evidence for an association between serum triglycerides and PC recurrence is mixed [14, 23].…”
Section: Introductionmentioning
confidence: 99%
“…A 3-year fol-low up of 14,241 men at risk (46) found that neither the total CH, nor LDL-C or HDL-C were associated with the risk of progressive prostate cancer. A meta-analysis of 6 RCTs and 13 observational studies did not reveal any association between statin use and prostate cancer (47).…”
Section: Evidence Against a Low Cholesterol Being Associated With Cancermentioning
confidence: 98%