2012
DOI: 10.1155/2012/248607
|View full text |Cite
|
Sign up to set email alerts
|

The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer

Abstract: An association between the metabolic syndrome and reduced testosterone levels has been identified, and a specific inverse relationship between insulin and testosterone levels suggests that an important metabolic crosstalk exists between these two hormonal axes; however, the mechanisms by which insulin and androgens may be reciprocally regulated are not well described. Androgen-dependant gene pathways regulate the growth and maintenance of both normal and malignant prostate tissue, and androgen-deprivation ther… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
14
0

Year Published

2013
2013
2024
2024

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 17 publications
(15 citation statements)
references
References 138 publications
(171 reference statements)
1
14
0
Order By: Relevance
“…These inhibitors could be useful in prostate cancer patients and may reduce autocrine/paracrine ghrelin-stimulated cell proliferation. GOAT inhibitors might also be useful for improving glucose tolerance in patients with hyperinsulinaemia and impaired glucose tolerance which results from androgen withdrawal therapy for advanced prostate cancer [45]. …”
Section: Resultsmentioning
confidence: 99%
“…These inhibitors could be useful in prostate cancer patients and may reduce autocrine/paracrine ghrelin-stimulated cell proliferation. GOAT inhibitors might also be useful for improving glucose tolerance in patients with hyperinsulinaemia and impaired glucose tolerance which results from androgen withdrawal therapy for advanced prostate cancer [45]. …”
Section: Resultsmentioning
confidence: 99%
“…This association has a strong relation to insulin resistance, hyperinsulinemia, steroid and peptide hormones (reduced androgens levels, increased estrogens levels, increased insulin, etc.) and inflammatory markers [23][24][25][26][27].…”
Section: Discussionmentioning
confidence: 99%
“…Elevated circulating IGF-1 has been epidemiologically linked to risk of various cancer types including prostate cancer, 20-22 and in vivo models implicate IGF-1 in prostate tumorigenesis. 7,8,23 Additionally, binding of IGF-1 to the IGF-1R activates several pathways such as the phosphatidylinositol 3-kinase (PI3K)/Akt and the Ras/mitogen-activated protein kinase pathways, that mitigate cell processes including cell growth, survival, and angiogenesis (usually upregulated in 30-50% of prostate cancer) with downstream effects culminating in increased glucose metabolism, inhibition of apoptosis, and stimulation of cell proliferation.…”
Section: Mets and Prostate Cancermentioning
confidence: 99%
“…Indeed, IGF-1 is able to stimulate androgen-sensitive and androgen-independent prostate cancer in human cell lines. 22 …”
Section: Mets and Prostate Cancermentioning
confidence: 99%