Low-level laser therapy, at 60 J/cm2 associated with a Biosilicate® increase in bone deposition and indentation biomechanical properties of callus in osteopenic rats

Fangel, Renan; Bossini, Paulo Sérgio; Rennó, Ana Cláudia Muniz; Ribeiro, Daniel Araki; Wang, Charles Chenwei; Toma, Renata Luri; Nonaka, Keico Okino; Driusso, Patrícia; Parizotto, Nivaldo Antônio; Oishi, Jorge

doi:10.1117/1.3598847

Cited by 23 publications

(27 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The irradiation frequency was based on similar studies in which bone healing after LLLT was evaluated. 16,36 Most of the studies were performed for five sessions per week. However, different treatment application protocols were reported for LLLT at different powers for bone healing.…”

mentioning

confidence: 99%

The efficacy of low-level 940 nm laser therapy with different energy intensities on bone healing

et al. 2017

View full text Add to dashboard Cite

The aim of this study was to evaluate the efficacy of low-level 940 nm laser therapy with energy intensities of 5, 10 and 20 J/cm 2 on bone healing in an animal model. A total of 48 female adult Wistar rats underwent surgery to create bone defects in the right tibias. Low-level laser therapy (LLLT) was applied immediately after surgery and on post-operative days 2, 4, 6, 8, 10 and 12 in three study groups with energy intensities of 5 J/cm 2 , 10 J/cm 2 and 20 J/cm 2 using a 940 nm Gallium-Aluminium-Arsenide (Ga-Al-As) laser, while one control group underwent only the tibia defect surgery. All animals were sacrificed 4 or 8 weeks post-surgery. Fibroblasts, osteoblasts, osteocytes, osteoclasts and newly formed vessels were evaluated by a histological examination. No significant change was observed in the number of osteocytes, osteoblasts, osteoclasts and newly formed vessels at either time period across all laser groups. Although LLLT with the 10 J/cm 2 energy density increased fibroblast activity at the 4th week in comparison with the 5 and 20 J/cm 2 groups, no significant change was observed between the laser groups and the control group. These results indicate that low-level 940 nm laser with different energy intensities may not have marked effects on the bone healing process in both phases of bone formation.

show abstract

mentioning

confidence: 99%

The efficacy of low-level 940 nm laser therapy with different energy intensities on bone healing

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Considerando os critérios de inclusão adotados, foram encontrados um total de 30 estudos nas bases de dados consultadas, dos quais quinze (50%) foram realizados em tendão 3,4,6,9,[22][23][24][31][32][33][34][35][36][37][38] , dez (33,33%) em musculos 12,14,[39][40][41][42][43][44][45] , e cinco (16,66%) em osso e/ou articulação 13,25,[46][47][48] Os resultados mais expressivos obtidos com a terapia foram: diminuição da resposta inflamatória mediante redução de células inflamatórias e modulação de mediadores da inflamação (36,66%), e o aumento da síntese de colágeno (13,33%). Alguns dos demais resultados (50,01%) mencionados foram: angiogênese; redução do estresse oxidativo, do colágeno e da fibrose; aumento do tecido de granulação, da remodelação e síntese óssea, assim como da expressão da proteína da diferenciação miogênica (MyoD) e do fator de crescimento endotelial vascular (VEGF).…”

Section: Resultsunclassified

“…Os condroblastos são células que secretam componentes da matriz extracelular para a formação da estrutura cartilaginosa, enquanto os osteoblastos participam da síntese dos componentes da matriz óssea, expressam fosfatase alcalina, enzima que permite a mineralização da matriz, e inclusive secretam fatores de crescimento. Fangel et al 46 e Fernandes et al 48 também descreveram aumento da síntese óssea após tratamento com laserterapia na tíbia de ratos. Os autores observaram, mediante avaliação histopatológica, neoformação óssea particularmente na análise realizada cinco dias após lesão traumática e tratamento.…”

Section: Discussionunclassified

Laserterapia Em Afecções Locomotoras: Revisão Sistemática De Estudos Experimentais

Souza

Silva

2016

Rev Bras Med Esporte

View full text Add to dashboard Cite

RESUMOIntrodução: Ao longo dos anos a fisioterapia tem contribuído para o tratamento das lesões musculotendí-neas e osteoarticulares pela utilização de diversos recursos eletrotermofototerapêuticos como, por exemplo, o laser de baixa potência. Objetivo: A finalidade desse estudo foi identificar mediante revisão sistemática, o efeito da laserterapia de baixa potência em afecções do sistema locomotor de ratos, com destaque para a dose de energia e o comprimento de onda utilizado, assim como para a resposta ao tratamento. Métodos: Foram consultadas as bases de dados Medline, Lilacs, PEDro e SciELO, entre janeiro de 2005 a maio de 2013, utilizando os termos "tendinopathy", "laser therapy", "rats", "tendon", "muscle", "bone", "low-level laser therapy", assim como "tendinopatia", "laserterapia", "ratos", "tendão", "músculo", "osso" e "laser de baixa potência". Apenas foram incluídos estudos experimentais publicados nos idiomas português e inglês, que induziram lesão em tendões, músculos, ossos e/ou articulação, tratada com laserterapia, associada ou não a outros tratamentos. Resultados: Foi encontrado um total de 30 estudos experimentais nas bases de dados consultadas, dos quais 15 (50%) foram realizados em tendão, 10 (33,33%) em músculo e cinco (16,66%) em osso e/ou articulação. As doses de energia mais comumente utilizadas foram de 3 J (26,66%) e 1 J (16,66%). Já os comprimentos de onda foram de 904 nm (21,21%) e 830 nm (21,21%). Conclusão: A informação mais expressiva obtida com a terapia foi a diminuição da resposta inflamatória (36,66%) em lesões ortopédicas agudas. May 2013, using the terms "tendinopathy", "laser therapy", "rats", "tendon", "muscle", "bone", "low-level laser therapy", as well as "tendinopatia", "laserterapia", "ratos", "tendão", " músculo", "osso" and "laser de baixa potência". Only experimental studies published in Portuguese and English and that induced lesion in tendons, muscles, bones and/or joints, treated Descritores

show abstract

“…In another study, LLLT (685nm, 35mW, 10 J/cm 2 ) demonstrated positive photobiomodulation effects as evidenced by stimulated vascularization, fibroblast proliferation and collagen deposition at its initial stages of bone tissue regeneration surrounding the nanomaterial based implants (poly-L-lactic/ polyglycolic acid) in the femur of rats (Freddo et al, 2009). Besides reducing inflammation, when LLLT (830nm, 100 mW/cm 2 , 60 J/cm 2 ) was used post-surgery for bone-fracture consolidation in tibias of osteoporotic rats, in conjunction with Biosilicate®, (a fully crystallized bioactive glass ceramic fillers), a significantly increased deposition of new bone tissue and improved biomechanical properties were observed compared to without nanomaterial-assisted device (Fangel et al, 2011). Nissan et al (2006) demonstrated that GaAs laser-therapy (904nm, 0,72 J, 4 mW/cm 2 ) resulted in new bone formation around hydroxyapatite implants and led to significant increase in the total bone area in rat mandibles by affecting calcium transport during new bone formation (Nissan et al, 2006).…”

Section: Phototherapy In Conjunction With Nanotechnology Used For mentioning

confidence: 99%

Shining light on nanotechnology to help repair and regeneration

Gupta

Avci

Sadasivam

et al. 2013

Biotechnology Advances

107

View full text Add to dashboard Cite

Phototherapy can be used in two completely different but complementary therapeutic applications. While low level laser (or light) therapy (LLLT) uses red or near-infrared light alone to reduce inflammation, pain and stimulate tissue repair and regeneration, photodynamic therapy (PDT) uses the combination of light plus non-toxic dyes (called photosensitizers) to produce reactive oxygen species that can kill infectious microorganisms and cancer cells or destroy unwanted tissue (neo-vascularization in the choroid, atherosclerotic plaques in the arteries). The recent development of nanotechnology applied to medicine (nanomedicine) has opened a new front of advancement in the field of phototherapy and has provided hope for the development of nanoscale drug delivery platforms for effective killing of pathological cells and to promote repair and regeneration. Despite the well-known beneficial effects of phototherapy and nanomaterials in producing the killing of unwanted cells and promoting repair and regeneration, there are few reports that combine all three elements i.e. phototherapy, nanotechnology and, tissue repair and regeneration. However, these areas in all possible binary combinations have been addressed by many workers. The present review aims at highlighting the combined multi-model applications of phototherapy, nanotechnology and, reparative and regeneration medicine and outlines current strategies, future applications and limitations of nanoscale-assisted phototherapy for the management of cancers, microbial infections and other diseases, and to promote tissue repair and regeneration.

show abstract

Low-level laser therapy, at 60 J/cm2 associated with a Biosilicate® increase in bone deposition and indentation biomechanical properties of callus in osteopenic rats

Cited by 23 publications

References 21 publications

The efficacy of low-level 940 nm laser therapy with different energy intensities on bone healing

The efficacy of low-level 940 nm laser therapy with different energy intensities on bone healing

Laserterapia Em Afecções Locomotoras: Revisão Sistemática De Estudos Experimentais

Shining light on nanotechnology to help repair and regeneration

Contact Info

Product

Resources

About