Low-Frequency Transcranial Magnetic Stimulation in Patients with Fibromyalgia and Major Depression

Carretero, Blanca; Martin, Ma J.; Juan, Antonio Ruiz de León San; Pradana, Ma Luz; Martín, B.; Carral, Maria; Jimeno, Teresa; Pareja, Antonio; Montoya, Pedro; Aguirre, Iratxe; Salvà, Joan; Roca, Miquel; Gili, Margalida; Garcı́a-Toro, Mauro

doi:10.1111/j.1526-4637.2009.00625.x

Cited by 53 publications

(53 citation statements)

References 26 publications

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“…Although the data in the literature are not homogeneous, both HF and LF protocols seem to have similar response rates (Brunoni et al, 2009;Carretero et al, 2009;Eche et al, 2012;Fitzgerald et al, 2009;Pallanti et al, 2010;Schutter, 2010). We provide here further indication of the value of LF-rTMS in a large sample with MDD, including elderly people, with an efficacy similar to that of HF-TMS, as reported by Milev et al (2009).…”

Section: Discussionsupporting

confidence: 74%

rTMS for pharmacoresistant major depression in the clinical setting of a psychiatric hospital: Effectiveness and effects of age

Ciobanu¹,

Girard²,

Marin³

et al. 2013

Journal of Affective Disorders

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Section: Discussionsupporting

confidence: 74%

rTMS for pharmacoresistant major depression in the clinical setting of a psychiatric hospital: Effectiveness and effects of age

Ciobanu¹,

Girard²,

Marin³

et al. 2013

Journal of Affective Disorders

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“…There were also studies that used low frequency for pain relief in FM. A study that had four patients found pain improvement, but in a second study, no difference was reported between the sham and real treatment groups (31,32). However, in both studies, LF-rTMS stimulation was applied to the prefrontal cortex area.…”

Section: Discussionmentioning

confidence: 99%

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Yağcı¹,

Ağırman²,

Öztürk³

et al. 2014

Turk J Phys Med Rehab

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ÖzetAmaç: Medikal tedaviye dirençli fibromiyalji hastalarında motor korteks alana uygulanan düşük frekanslı tekrarlayıcı transkraniyal manyetik stimülasyonun (tTMS) etkinliğini araştırmak. Gereç ve Yöntemler: Toplam 25 hasta randomize olarak aktif ve plasebo gruplarına ayrılarak çalışmaya alındı. Aktif tTMS grubu için stimülasyon sol primer motor korteks üzerinden motor eşik değerin %90'ı hesaplanarak 1 Hz ve 20 dakika uygulandı. Her seansta 1200 uyarı olmak üzere, iki hafta boyunca toplam 10 seans tedavi uygulandı. Plasebo grup için, parabolik koil 90° açı ile motor kortekse yerleştirildi ve aynı şekilde toplam 10 seans stimülasyon uygulandı. Sonuçlar, ağrı için vizüel analog skalası (VAS), Fibromiyalji Etkinlik Anketi (FIQ) ve Beck Depresyon Skalası (BDS) ile değerlendirildi. Bulgular: Her iki grupta da tedavi sonunda, 1 ve 3. ay sonunda ağrı derecesinde, FIQ ve BDS'de anlamlı iyileşme gözlendi. Ancak, aktif tTMS grubunda iyileşme plasebo gruba göre daha iyiydi. Tedavi sonu FIQ skorlarında aktif grupta, plasebo gruba göre istatistiksel olarak anlamlı iyileşme gözlendi. Diğer değerlendirmelerde gruplar arasında istatistiksel farklılık saptanmadı. Sonuç: Primer motor korteks üzerine düşük doz tTMS uygulamasının uzun süreli takiplerde fibromiyalji hastalarında plaseboya göre anlamlı iyileşme göstermediği görülmüştür. Anahtar Kelimeler: Fibromiyalji, transkraniyal manyetik stimülasyon, ağrı AbstractObjective: To investigate the effectiveness of low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) to the motor cortex area in fibromyalgia patients who are resistant to medical treatment. Material and Methods: A total of 25 patients were randomly assigned to the study, who were in the active rTMS (n=13) or sham stimulation (n=12) group. For the rTMS group, the main stimulation parameters were 90% of motor threshold for 60 seconds at 1 Hz and a 45-second interval between each train. Ten sessions of low-frequency rTMS, which had a total of 1200 pulses at each session, were applied to the left primary motor cortex area daily over a period of 2 weeks. For the sham group, the same parabolic coil was placed at 90° angles to the motor cortex area, and the patients received 10 sessions of sham stimulation. The outcome parameters were pain intensity, which was measured by visual analog scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), and the Beck Depression Inventory (BDI). Results: A significant improvement in pain intensity, FIQ, and BDI scores was seen at the 10 th day and first and third months in both groups. Although the mean of parameters of the rTMS groups was better than the sham group, the difference did not reach statistical significance, except FIQ scores at the 10 th day in the real rTMS group. Conclusion: Patients with fibromyalgia who enroll in real TMS did not present significant differences in long-term follow-ups with respect to those who enrolled in the sham TMS group.

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“…94,95 rTMS of the M1 and dorsolateral prefrontal cortex has been shown to be efficacious in reducing pain associated with fibromyalgia in various studies. 35,44,[96][97][98][99][100] Sampson and colleagues 97 reported the efficacy of low-frequency (1-Hz) rTMS of the right DLPFC in 4 patients with depression and fibromyalgia. Average pain reduced from a pretreatment level of 8.2 (Likert scale) to 1.5 after rTMS and 2 patients reported complete resolution of pain in this study.…”

Section: Rtms Of M1 For Chronic Painmentioning

confidence: 97%

Transcranial Magnetic Stimulation for Chronic Pain

Young

Sharma

Deogaonkar

2014

Neurosurgery Clinics of North America

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Low-Frequency Transcranial Magnetic Stimulation in Patients with Fibromyalgia and Major Depression

Abstract: With the methodology used in this study, patients with fibromyalgia and major depression who received real magnetic stimulation did not present significant differences in symptoms with respect to those who received sham magnetic stimulation.

Cited by 53 publications

References 26 publications

rTMS for pharmacoresistant major depression in the clinical setting of a psychiatric hospital: Effectiveness and effects of age

rTMS for pharmacoresistant major depression in the clinical setting of a psychiatric hospital: Effectiveness and effects of age

Is the Transcranial Magnetic Stimulation an Adjunctive Treatment in Fibromyalgia Patients?

Transcranial Magnetic Stimulation for Chronic Pain

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