Transcranial Magnetic Stimulation for Chronic Pain

Young, Nicole A.; Sharma, Mayur; Deogaonkar, Milind

doi:10.1016/j.nec.2014.07.007

Cited by 28 publications

(22 citation statements)

References 114 publications

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“…Hence, novel strategies targeting neuropathic pain are much needed clinically. Indeed, non-pharmacological approaches, such as transcutaneous electrical nerve stimulation [5], transcranial magnetic stimulation [6], and electro acupuncture [7] have been proven to significantly alleviate neuropathic pain. Nevertheless, the long-term efficacy of these approaches is yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats

Zhao

Pan

2017

J Headache Pain

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BackgroundHyperbaric oxygen (HBO) therapy is proven to attenuate neuropathic pain in rodents. The goal of the present study was to determine the potential involvement of the Kindlin-1/Wnt-10a signaling pathway during astrocyte activation and inflammation in a rodent model of neuropathic pain.MethodsRats were assigned into sham operation, chronic constriction injury (CCI), and CCI + HBO treatment groups. Neuropathic pain developed in rats following CCI of the sciatic nerve. Rats in the CCI + HBO group received HBO treatment for five consecutive days beginning on postoperative day 1. The mechanical withdrawal threshold (MWT) and the thermal withdrawal latency (TWL) tests were performed to determine mechanical and heat hypersensitivity of animals, respectively. Kindlin-1, Wnt-10a and β-catenin protein expression was examined by immunohistochemistry and Western blot analysis. Expression of tumor necrosis factor (TNF)-α was also determined by ELISA.ResultsOur findings demonstrated that HBO treatment significantly suppressed mechanical and thermal hypersensitivity in the CCI neuropathic pain model in rats. HBO therapy significantly reversed the up-regulation of Kindlin-1 in dorsal root ganglia (DRG), spinal cord, and hippocampus of CCI rats. CCI-induced astrocyte activation and increased levels of TNF-α were efficiently reversed by HBO (P < 0.05 vs. CCI). HBO also reversed Wnt-10a up-regulation induced by CCI in the DRG, spinal cord, and hippocampus (P < 0.05 vs. CCI).ConclusionsOur findings demonstrate that HBO attenuated CCI-induced rat neuropathic pain and inflammatory responses, possibly through regulation of the Kindlin-1/Wnt-10a signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats

Zhao

Pan

2017

J Headache Pain

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“…Bioelectrical activity of the neurons in mollusks and warmblooded animals is mainly provided by the ac tivity of sodium, calcium and potassium ion channels, which are built and operate according to the same general principles [3][4][5][6][7][8]. It enable us to use the neu rons of mollusks as eligible models [9][10][11][12][13][14][15][16][17][18], in paral lel with the neurons of warmblooded animals, for experimental research on the performance of the ion channels and the mechanisms of influences on them made by various physical factors, chemical substanc es and pharmaceutical drugs either of already known nature or being designed.…”

Section: Methodsmentioning

confidence: 99%

Mechanisms of electromagnetic influences and effects on membrane systems in neurons and cardiomyocytes

Орлов¹,

Rudenko²,

Shikhlyarova³

et al. 2017

Cardiometry

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AimThe aim of our studies was to discover responses of the membrane systems in neurons and cardiomyocytes as well as mechanisms of influences and effects produced by the broadband-spectrum stochastic electromagnetic radiation (BBSS EMR) on them according to data on membrane potential (MP) levels and action potential (AP) parameters obtained by us. Materials and methodsNeurons from the isolated central neural system (CNS) of the snail Helix pomatia were selected to serve as a model for our experiments. We applied an electrophysiological technique implying recording of intracellular potentials of a neuron. The presented research work is of fundamental nature and reveals some intimate mechanisms of actions made by electromagnetic radiation (EMR) on the cytoplasm membrane of a neuron and its channels that is applicable to cardiomyocytes. An absolutely exclusive distinctive feature of our work is that the specific BBSS EMR used in our experiments has unique characteristics and offers broadband stochastic radiated frequencies in the range from 10 n Hz to 10 m Hz at an integral radiation power of only 0,1 µW. Another distinguishing feature of the applied EMR parameters is that the stochastically organized EMR is supplied under such action rhythms, which are close to the natural alpha-, theta-and delta-rhythms of an EEG as well to the natural background base resonance frequency of the Earth, which has been physically measured to be 7,83 Hz, that is evolutionary significant for biological systems. Results and discussionWe are pioneers in the world science who succeeded in ob-

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“…This case study shows that, for a given circumstance, certain neurostimulative therapies may be more successful than others [9,10]. For two young female patients presenting with two years of CRPS in their right upper extremity, rTMS over a period as long as 3 months better resolved pain symptoms than scrambler therapy.…”

Section: Discussionmentioning

confidence: 82%

Scrambler Therapy and Transcranial Magnetic Stimulation: A Case Report of Varying Pain Reduction in Two Patients

Cruciani¹

2016

JOJCS

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Peripheral nerve stimulation via scrambler therapy is a neurostimulative technique that may improve chronic neuropathic pain. Repetitive transcranial magnetic stimulation (rTMS) works by a different mechanism than scrambler therapy; however, this therapy is also successful in alleviating chronic neuropathic pain. Two patients with complex regional pain syndrome (CRPS) were treated for pain via scrambler therapy. When scrambler therapy was found to be ineffective, these patients were treated with repetitive transcranial magnetic stimulation. Each of these patients experienced pain relief when treated with rTMS. Comparing the course of treatment for two patients with CRPS may further guide clinicians in determining the appropriate neurostimulative therapies for given situations.

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Transcranial Magnetic Stimulation for Chronic Pain

Cited by 28 publications

References 114 publications

Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats

Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats

Mechanisms of electromagnetic influences and effects on membrane systems in neurons and cardiomyocytes

Scrambler Therapy and Transcranial Magnetic Stimulation: A Case Report of Varying Pain Reduction in Two Patients

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