Low fasting low high-density lipoprotein and postprandial lipemia

Kolovou, Genovefa; Anagnostopoulou, Katherine K.; Pilatis, Nektarios D.; Kafaltis, Nikolaos; Sorodila, K.; Psarros, Eleftherios; Cokkinos, Dennis V.

doi:10.1186/1476-511x-3-18

Cited by 20 publications

(6 citation statements)

References 38 publications

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“…On the other hand, Simo et al failed to show any improvement in fasting TG levels after lovastatin (40 mg/day) administration whereas for postprandial TG levels, a non-significance trend towards reduction was observed [121]. Taking into account that the fasting TG concentration is the primary determinant of the magnitude of postprandial lipemia [155], drugs affecting fasting TG levels may effectively diminish postprandial hypertriglyceridemia.…”

Section: Lovastatinmentioning

confidence: 95%

The Effect of Statins on Postprandial Lipemia

Kolovou¹,

Anagnostopoulou²,

Salpea³

et al. 2007

CDT

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Several studies showed that postprandial plasma triglyceride (TG) concentrations are higher in patients with coronary heart disease. TG-rich lipoprotein remnants accumulated in the postprandial state are involved in atherogenesis and in events leading to thrombosis. Lipid lowering drugs, such as 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) are of significant benefit in the primary and secondary prevention of atherosclerosis. Statins can decrease total cholesterol and low density lipoprotein cholesterol as well as TG concentrations and improve postprandial lipoprotein metabolism. Since abnormal postprandial lipemia is associated with pathological conditions, its treatment is relevant. This review considers the effect of statins on postprandial lipemia.

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Section: Lovastatinmentioning

confidence: 95%

The Effect of Statins on Postprandial Lipemia

Kolovou¹,

Anagnostopoulou²,

Salpea³

et al. 2007

CDT

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“…The 30-year follow up of the Framingham Heart Study showed an increase in CHD risk with higher levels of plasma TG and demonstrated that this effect is more pronounced in women [30]. Hokanson and Austin [28] considered 17 population-based prospective studies including men (n = 46,413) and women (n = 10,864) which evaluated the association between TG levels and the incidence of vascular disease. Some of these studies corrected for the contribution of HDL-C and found that TGs remained independent predictors of risk.…”

Section: Elevated Tg Levels and The Increased Risk Of Chdmentioning

confidence: 99%

“…Additionally, chronic consumption of low energy-high carbohydrate diets, often used for weight loss, has a tendency to exaggerate plasma triglyceride (TG) levels [2]. Disturbed postprandial lipaemia occurs in patients with coronary heart disease (CHD) [3][4][5] and other conditions associated with an increased risk of vascular disease such as hypertension, obesity, metabolic syndrome and familial hypercholesterolaemia [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Clinical Relevance of Postprandial Lipaemia

Kolovou¹,

Anagnostopoulou²,

Daskalopoulou³

et al. 2005

CMC

115

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Several studies showed that after a fatty meal, plasma triglyceride (TG) levels are higher in patients with coronary heart disease. This abnormality may explain why some individuals develop atherosclerotic disease despite normal fasting lipid values. TG-rich lipoproteins are involved in atherosclerosis and thrombosis. TG, remnant-like particle (RLP) cholesterol (RLP-C) and RLP-TG increase after fat load and could contribute to atherothrombosis. Postprandial lipaemia is not a uniform abnormality. Its pathophysiology is not yet entirely clarified; possibly, the response to dietary fat is a polygenic phenomenon. However, a link with insulin resistance is likely; this link as well as that with obesity is discussed. A substantial part of life is spent in the postprandial state. Therefore, several investigators described fat load tests. However, it is still difficult to establish normal postprandial TG ranges since only small numbers of subjects were studied and there is as yet no standardised method. A more simplified fat load test should be established for 'routine' use. In this review, we consider the metabolic features, prevalence and management of postprandial lipaemia. Treatment may involve lifestyle measures as well as the use of lipid lowering (e.g. fibrates or statins), weight reducing and hypoglycaemic drugs.

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“…Hence, altogether, these mechanisms explain the lowering of postprandial circulating total- and chylomicron-triglycerides and chylomicron-cholesterol and fasting circulating total- and LDL-cholesterol. Unexpectedly, a modulation of fasting circulating triglycerides was not observed despite a correlation between their levels and the magnitude of postprandial lipemia has been reported [58,61,63,66,126,127]. The results of the Spanish team mirror the fact that lower postprandial circulating triglycerides favor higher fasting circulating HDL-cholesterol [127,128] and, curiously and accordingly, the increase of fasting circulating HDL-cholesterol was statistically significant only in the more postprandial circulating total-triglyceride-lowering responsive population sample, the healthy postmenopausal women [58,61,68,69,116].…”

Section: Discussionmentioning

confidence: 98%

Metabolic Syndrome Features: Is There a Modulation Role by Mineral Water Consumption? A Review

2019

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Metabolic syndrome (MetSyn) promotes, among others, the development of atherosclerotic cardiovascular disease and diabetes. Its prevalence increases with age, highlighting the relevance of promoting precocious MetSyn primary prevention and treatment with easy-to-implement lifestyle interventions. MetSyn features modulation through mineral water consumption was reviewed on Pubmed, Scopus and Google Scholar databases, using the following keywords: metabolic syndrome, hypertension, blood pressure (BP), cholesterol, triglycerides, apolipoprotein, chylomicron, very low-density lipoprotein, low-density lipoprotein, high-density lipoprotein (HDL), glucose, insulin, body weight, body mass index, waist circumference (WC), obesity and mineral(-rich) water. Twenty studies were selected: 12 evaluated BP, 13 assessed total-triglycerides and/or HDL-cholesterol, 10 analysed glucose and/or 3 measured WC. Mineral waters were tested in diverse protocols regarding type and composition of water, amount consumed, diet and type and duration of the study. Human and animal studies were performed in populations with different sizes and characteristics. Distinct sets of five studies showed beneficial effects upon BP, total-triglycerides, HDL-cholesterol and glucose. WC modulation was not reported. Minerals/elements and active ions/molecules present in mineral waters (and their pH) are crucial to counterbalance their inadequate intake and body status as well as metabolic dysfunction and increased diet-induced acid-load observed in MetSyn. Study characteristics and molecular/physiologic mechanisms that could explain the different effects observed are discussed. Further studies are warranted for determining the mechanisms involved in the putative protective action of mineral water consumption against MetSyn features.

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Low fasting low high-density lipoprotein and postprandial lipemia

Cited by 20 publications

References 38 publications

The Effect of Statins on Postprandial Lipemia

The Effect of Statins on Postprandial Lipemia

Clinical Relevance of Postprandial Lipaemia

Metabolic Syndrome Features: Is There a Modulation Role by Mineral Water Consumption? A Review

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