The Effect of Statins on Postprandial Lipemia

Kolovou, Genovefa; Anagnostopoulou, Katherine K.; Salpea, Klelia D.; Daskalopoulou, Stella S.; Mikhailidis, Dimitri P.

doi:10.2174/138945007780362809

Cited by 26 publications

(13 citation statements)

References 138 publications

(221 reference statements)

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“…This may be explained by the fact that most of the subjects in the present study were taking lipid-lowering medication with statins, which was not the case in our earlier studies (13,14). Statins have been found to decrease triglyceride concentrations and improve postprandial lipoprotein metabolism (45).…”

Section: Discussionmentioning

confidence: 57%

Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod protein

Mortensen

Hartvigsen

Brader

et al. 2009

The American Journal of Clinical Nutrition

130

107

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Background: Enhanced and prolonged postprandial triglyceride responses involve increased cardiovascular disease risk in type 2 diabetes. Dietary fat and carbohydrates profoundly influence postprandial hypertriglyceridemia, whereas little information exists on the effect of proteins. Objective: The objective was to compare the effects of the proteins casein, whey, cod, and gluten on postprandial lipid and incretin responses to a high-fat meal in persons with type 2 diabetes. Design: A crossover study was conducted in 12 patients with type 2 diabetes. Blood samples were collected over 8 h after ingestion of a test meal containing 100 g butter and 45 g carbohydrate in combination with 45 g casein (Cas-meal), whey (Whe-meal), cod (Codmeal), or gluten (Glu-meal). We measured plasma concentrations of triglycerides, retinyl palmitate (RP), free fatty acids, insulin, glucose, glucagon, glucagon-like peptide 1, and glucose-dependent insulinotropic peptide. Results: The incremental area under the curve for triglyceride was significantly lower after the Whe-meal than after the other meals. The RP response was lower after the Whe-meal than after the Casmeal and Cod-meal in the chylomicron-rich fraction and higher after the Whe-meal than after Cod-and Glu-meals in the chylomicron-poor fraction. Free fatty acids were most pronouncedly suppressed after the Whe-meal. The glucose response was lower after the Whe-meal than after the other meals, whereas no significant differences were found in insulin, glucagon, glucagon-like peptide 1, and glucose-dependent insulinotropic peptide responses. Conclusion: The data suggest that as a supplement to a fat-rich meal in patients with type 2 diabetes, whey protein seems to outperform other proteins in terms of postprandial lipemia improvement, possibly because of the formation of fewer chylomicrons or increased clearance of chylomicrons. The trial was registered at clinicaltrials. gov as NCT00817973.Am J Clin Nutr 2009;90:41-8.

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Section: Discussionmentioning

confidence: 57%

Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod protein

Mortensen

Hartvigsen

Brader

et al. 2009

The American Journal of Clinical Nutrition

130

107

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“…154 There is evidence that they may also improve postprandial lipoprotein metabolism. 155 There are data indicating that 4 weeks therapy of atorvastatin 10mg daily may decrease postprandial large triglyceride-rich lipoproteins (containing chylomicrons) in hypertriglyceridemic patients. 156 In addition, it has been shown that pitavastatin 2mg/ day may result in reduction of both postprandial hypertriglyceridemia and endothelial dysfunction in obese subjects and in patients with stable coronary artery heart disease.…”

Section: Statinsmentioning

confidence: 99%

Postprandial dysmetabolism: Too early or too late?

Pappas¹,

Kandaraki²,

Tsirona³

et al. 2016

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postprandial dysmetabolism is a postprandial state characterized by abnormal metabolism of glucose and lipids and, more specifically, of elevated levels of glucose and triglyceride (Tg) containing lipoproteins. Since there is evidence that postprandial dysmetabolism is associated with increased cardiovascular mortality and morbidity, due to macro-and microvascular complications, as well as with conditions such as polycystic ovary syndrome (pCOS) and nonalcoholic fatty liver disease (NaFlD), it is recommended that clinicians be alert for early detection and management of this condition. management consists of a holistic approach including dietary modification, exercise and use of hypoglycemic and hypolipidemic medication aiming to decrease the postprandial values of circulating glucose and triglycerides. This review aims to explain glucose and lipid homeostasis and the impact of postprandial dysmetabolism on the cardiovascular system as well as to offer suggestions with regard to the therapeutic approach for this entity. however, more trials are required to prevent or reverse early and not too late the actual tissue damage due to postprandial dysmetabolism.

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“…Because the size of TRL pools are related to lipid subfraction patterns [118,119], similar to statins, the ezetimibe effect on particle size will be most pronounced in hypertriglyceridemic patients. In a recent study of patients with primary dyslipidemias, ezetimibe reduced the concentration of all LDL subfractions (tube gel, Lipoprint), with significant increases in the reduction of small, dense LDL particles and a shift toward larger and less atherogenic LDL particles, especially in patients with hypertriglyceridemia (TG > 200 mg/dl) [118].…”

Section: Lipoprotein Subclassmentioning

confidence: 99%